Emerging role of m6A modification in osteogenesis of stem cells

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway

(2021) Haibiao Xie et al.   Cell Death & Disease

Core–shell-Structured ZIF-8@PDA-HA with Controllable Zinc Ion Release and Superior Bioactivity for Improving a Poly-l-lactic Acid Scaffold

(2021) Cijun Shuai et al.   ACS Sustainable Chemistry & Engineering

Mechanical Alloying of Immiscible Metallic Systems: Process, Microstructure, and Mechanism

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RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation

(2021) Jing Wang et al.   Aging-US

Rare earth improves strength and creep resistance of additively manufactured Zn implants

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In-situ deposition of apatite layer to protect Mg-based composite fabricated via laser additive manufacturing

(2021) Youwen Yang et al.   Journal of Magnesium and Alloys

Dispersion strategies for low-dimensional nanomaterials and their application in biopolymer implants

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Pre-oxidation induced in situ interface strengthening in biodegradable Zn/nano-SiC composites prepared by selective laser melting

(2021) Chengde Gao et al.   Journal of Advanced Research

Magnetostrictive alloys: Promising materials for biomedical applications

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Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas

(2020) Wenxin Zeng et al.   Cancer Cell International

The significance of exosomes in the development and treatment of hepatocellular carcinoma

(2020) Xin Li et al.   Molecular Cancer

Clinical Applications and Future Directions of Minimal Residual Disease Testing in Multiple Myeloma

(2020) Stefania Oliva et al.   Frontiers in Oncology

Epidemiology and Risk Factors of Osteosarcoma

(2020) Leissan R. Sadykova et al.   CANCER INVESTIGATION

Methyltransferase‐like 3‐mediated N6‐methyladenosine modification of miR‐7212‐5p drives osteoblast differentiation and fracture healing

(2020) Bobin Mi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A metabolic labeling method detects m6A transcriptome-wide at single base resolution

(2020) Xiao Shu et al.   Nature Chemical Biology

Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine

(2020) Ye Wang et al.   Nature Chemical Biology

Magnetically actuated bone scaffold: Microstructure, cell response and osteogenesis

(2020) Cijun Shuai et al.   COMPOSITES PART B-ENGINEERING

METTL3 ‐mediated m 6 A mRNA methylation modulates tooth root formation via affecting NFIC translation

(2020) Rui Sheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanically driving supersaturated Fe–Mg solid solution for bone implant: Preparation, solubility and degradation

(2020) Cijun Shuai et al.   COMPOSITES PART B-ENGINEERING

Adjuvant Biophysical Therapies in Osteosarcoma

(2019) Valeria Carina et al.   Cancers

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

(2019) Huilin Huang et al.   NATURE

METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1/STAT5/C/EBPβ pathway via an m6A-YTHDF2–dependent manner

(2019) Yongxi Yao et al.   FASEB JOURNAL

Epigenetics as a New Frontier in Orthopedic Regenerative Medicine and Oncology

(2019) Andre J. Wijnen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The RNA N6-methyladenosine modification landscape of human fetal tissues

(2019) Shan Xiao et al.   NATURE CELL BIOLOGY

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation

(2019) Tongxing Song et al.   NUCLEIC ACIDS RESEARCH

N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction

(2019) Jiaxin Chen et al.   RNA Biology

FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export

(2019) Brittany M. Edens et al.   Cell Reports

The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1

(2019) Wujun Miao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage

(2019) Qian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Role of Exosomal Non-coding RNAs in Musculoskeletal Diseases

(2019) Chao Tu et al.   CURRENT PHARMACEUTICAL DESIGN

Anabolic effects of vitamin D and magnesium in aging bone

(2019) Sarah Erem et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m6A-demethylation of Nanog mRNA

(2019) Yihui Wang et al.   Science China-Life Sciences

METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate

(2019) Jing Chen et al.   LIFE SCIENCES

m6A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells

(2019) Gege Yan et al.   Molecular Therapy-Nucleic Acids

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential

(2018) Dandan Yang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide identification of m6A-associated SNPs as potential functional variants for bone mineral density

(2018) X. B. Mo et al.   OSTEOPOROSIS INTERNATIONAL

Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex

(2018) Eva Schöller et al.   RNA

Oxidative stress preconditioning of mouse perivascular myogenic progenitors selects a subpopulation of cells with a distinct survival advantage in vitro and in vivo

(2018) Cesare Gargioli et al.   Cell Death & Disease

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

RNA Methylation in ncRNA: Classes, Detection, and Molecular Associations

(2018) Giulia Romano et al.   Frontiers in Genetics

FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism

(2018) Ruifan Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis

(2018) Guang-Si Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion

(2018) Zhenrui Li et al.   CELL RESEARCH

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

RNA m6A modification and its function in diseases

(2018) Jiyu Tong et al.   Frontiers of Medicine

A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

(2018) Rong Wu et al.   CELL RESEARCH

Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma

(2018) Dong Jiang et al.   Cell Death & Disease

Oral bisphosphonates and incidence of cancers in patients with osteoporosis: a systematic review and meta-analysis

(2018) Yingfang Deng et al.   Archives of Osteoporosis

Transcriptional profiling of human femoral mesenchymal stem cells in osteoporosis and its association with adipogenesis

(2017) Yong Jun Choi et al.   GENE

Regulatory Role of N6 -methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases

(2017) Wenqiang Wei et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy

(2017) D. Matthew Gianferante et al.   Nature Reviews Endocrinology

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Effect of three remplissage techniques on tendon coverage and shoulder kinematics: a navigated robotic biomechanical study

(2016) Chung Hui James Tan et al.   BMC MUSCULOSKELETAL DISORDERS

Metastatic osteosarcoma: a challenging multidisciplinary treatment

(2016) Cristina Meazza et al.   Expert Review of Anticancer Therapy

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

m6A modulates neuronal functions and sex determination in Drosophila

(2016) Tina Lence et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents

(2016) Alyson A. Endicott et al.   PEDIATRIC BLOOD & CANCER

Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure

(2016) Cosimo Neglia et al.   International Journal of Environmental Research and Public Health

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

MicroRNAs in Bone Balance and Osteoporosis

(2015) Junying Chen et al.   DRUG DEVELOPMENT RESEARCH

S-nitrosoglutathione reductase–dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis

(2015) Yenong Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

(2015) Benoit Moindrot et al.   Cell Reports

Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease

(2014) U. Chandola et al.   Briefings in Functional Genomics

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

(2013) Chacko Joseph et al.   Cell Stem Cell

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(2013) Peter Vrtačnik et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Imbalance Between Bone Formation and Resorption in Hematopoietic Stem/Progenitor Cells Mobilization

(2011) S.-D. Li et al.   TRANSPLANTATION PROCEEDINGS

Osteosarcoma

(2010) J. Ritter et al.   ANNALS OF ONCOLOGY

International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons

(2009) Lisa Mirabello et al.   INTERNATIONAL JOURNAL OF CANCER