The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice

(2018) Gregor Sachse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

Dynamic m6A modification regulates local translation of mRNA in axons

(2017) Jun Yu et al.   NUCLEIC ACIDS RESEARCH

Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module

(2017) Gina M. Calabrese et al.   Cell Systems

CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice

(2016) Michele Doucet et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features

(2016) Yuan Zhou et al.   NUCLEIC ACIDS RESEARCH

Targeting NF- B in glioblastoma: A therapeutic approach

(2016) D. Friedmann-Morvinski et al.   Science Advances

The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells

(2015) KATJA STORCH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair

(2015) L-L Cao et al.   ONCOGENE

Loss of FTO in adipose tissue decreasesAngptl4translation and alters triglyceride metabolism

(2015) Chao-Yung Wang et al.   Science Signaling

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

Loss of FTO in adipose tissue decreasesAngptl4translation and alters triglyceride metabolism

(2015) Chao-Yung Wang et al.   Science Signaling

The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation

(2015) Meizi Zhang et al.   PLoS One

Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

(2014) Bo Yu et al.   NATURE MEDICINE

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Hsp70 in cancer: back to the future

(2014) M Y Sherman et al.   ONCOGENE

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The Fat Mass and Obesity Associated Gene, FTO, Is Also Associated with Osteoporosis Phenotypes

(2011) Yan Guo et al.   PLoS One

Aging and bone loss: new insights for the clinician

(2011) Oddom Demontiero et al.   Therapeutic Advances in Musculoskeletal Disease

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Ubiquitin signalling in DNA replication and repair

(2010) Helle D. Ulrich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Osteoporosis: impact on health and economics

(2010) Nicholas Harvey et al.   Nature Reviews Rheumatology

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of Apoptotic and Inflammatory Cell Signaling in Cerebral Ischemia

(2009) Rona G. Giffard et al.   ANESTHESIOLOGY

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library

(2008) Jurre Hageman et al.   CELL STRESS & CHAPERONES