In Vitro and In Vivo Studies Reveal that Hesperetin-7-O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity

Eubacterium rectale contributes to colorectal cancer initiation via promoting colitis

(2021) Yijia Wang et al.   Gut Pathogens

Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism

(2020) Su-Ling Zeng et al.   Science Advances

Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor

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Astragalin Attenuates Dextran Sulfate Sodium (DSS)-Induced Acute Experimental Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting NF-κB Activation in Mice

(2020) Lei Peng et al.   Frontiers in Immunology

Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health

(2020) Arghya Mukherjee et al.   Gut Microbes

Short-Term Intake of Hesperetin-7-O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice

(2020) Fang Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

(2019) Wei Qin et al.   Nature Chemical Biology

Remission Effects of Dietary Soybean Isoflavones on DSS-Induced Murine Colitis and an LPS-Activated Macrophage Cell Line

(2019) Sang-Eun Kim et al.   Nutrients

Beneficial Effects of Dietary Polyphenols on High-Fat Diet-Induced Obesity Linking with Modulation of Gut Microbiota

(2019) Jianhui Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain

(2019) Kan Gao et al.   Advances in Nutrition

Flavonoid metabolism: the interaction of metabolites and gut microbiota

(2018) Kaeko Murota et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Aryl hydrocarbon receptor and intestinal immunity

(2018) Bruno Lamas et al.   Mucosal Immunology

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

(2018) Yun Teng et al.   Cell Host & Microbe

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

(2017) Adonia E. Papathanassiu et al.   Nature Communications

Potential of Plant-sourced Phenols for Inflammatory Bowel Disease

(2017) Hai-tao Xiao et al.   CURRENT MEDICINAL CHEMISTRY

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

(2016) Harding H. Luan et al.   Cell Metabolism

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

(2016) Floris Imhann et al.   GUT

A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease

(2016) Penelope Pelczar et al.   SCIENCE

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans

(2015) Lucas Actis-Goretta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Supplemental Naringenin Prevents Intestinal Barrier Defects and Inflammation in Colitic Mice

(2013) Tomoyo Azuma et al.   JOURNAL OF NUTRITION

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: Enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori

(2012) Young-Su Lee et al.   FOOD CHEMISTRY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from α-rhamnosidase-treated orange juice in human subjects

(2010) Lea Bredsdorff et al.   BRITISH JOURNAL OF NUTRITION

Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats

(2009) Véronique Habauzit et al.   BRITISH JOURNAL OF NUTRITION

Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium

(2009) Lei Xu et al.   PHYTOMEDICINE

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

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