Article
Immunology
S. M. Shamsul Islam, Hye-Myung Ryu, Hasan M. Sayeed, Hae-Ok Byun, Ju-Yang Jung, Hyoun-Ah Kim, Chang-Hee Suh, Seonghyang Sohn
Summary: The study aimed to investigate the effect of Eubacterium rectale administration on DC activation and systemic inflammation in HSV-1-induced Behcet's disease. Results showed that E. rectale reduced the frequency of CD83+ cells and increased NK1.1+ cells in BD mice, improving symptoms. Co-administration of colchicine and E. rectale also decreased the frequency of CD83+ cells, suggesting E. rectale as a potential therapeutic adjuvant for BD management.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Haiyang Lu, Xiaoqiang Xu, Di Fu, Yubei Gu, Rong Fan, Hongmei Yi, Xiangyi He, Chaofu Wang, Binshen Ouyang, Ping Zhao, Li Wang, Pengpeng Xu, Shu Cheng, Zhifeng Wang, Duowu Zou, Lizhong Han, Weili Zhao
Summary: This study explores the role of gut microbiota in lymphoma progression. The researchers found a distinct microbiota profile of intestinal lymphoma, with decreased symbiotic microbes, particularly Eubacterium rectale. Transfer of E. rectale-deficit microbiota to mice caused inflammation and TNF production, while E. rectale treatment reduced TNF levels and the incidence of lymphoma in mice. The researchers also found that lipopolysaccharide from the resident microbiota of lymphoma patients and mice synergizes with TNF signaling, reinforcing the NF-kappa B pathway, and enhancing intestinal B cell survival and proliferation.
CELL HOST & MICROBE
(2022)
Article
Biochemistry & Molecular Biology
Khalil El Khatabi, Shashank Kumar, Reda El-Mernissi, Atul Kumar Singh, Mohammed Aziz Ajana, Tahar Lakhlifi, Mohammed Bouachrine
Summary: This research aims to screen out potential inhibitors of Eubacterium rectale from coriander for colorectal cancer prevention. Rutin and Gallocatechin are identified as the most potential inhibitors among the 8 selected compounds through molecular docking and molecular dynamics simulation. Further studies are needed to confirm their therapeutic potential.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Gastroenterology & Hepatology
Marion Avril, R. William DePaolo
Summary: Colorectal cancer (CRC) is a significant public health problem globally, with gut microbiota playing an important role in the disease's etiology. Further research is needed to clarify the specific roles of bacteria in CRC development.
Review
Cell Biology
Nora J. Foegeding, Zachary S. Jones, Mariana X. Byndloss
Summary: Landmark discoveries in the gut microbiome field have opened up new research avenues aimed at elucidating the impact of microbiota in colorectal cancer. An important challenge lies in determining the contribution of inherently variable environmental factors to carcinogenesis. Future research focused on unraveling host-microbe interactions in the colon may influence medical insights related to the prevention and treatment of colorectal cancer.
DISEASE MODELS & MECHANISMS
(2021)
Article
Immunology
Yingzhi Liu, Matthew T. V. Chan, Francis K. L. Chan, William K. K. Wu, Siew C. Ng, Lin Zhang
Summary: This study found that the mortality rate of COVID-19 is associated with the altered composition and functions of the gut microbiome in adults. Higher diversity of gut microbiome and reduction of specific butyrate-producing species were correlated with higher COVID-19 severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Seoung Woo Ryu, Ji-Sun Kim, Byeong Seob Oh, Won Jung Choi, Seung Yeob Yu, Jeong Eun Bak, Seung-Hwan Park, Se Won Kang, Jiyoung Lee, Won Yong Jung, Jung-Sook Lee, Ju Huck Lee
Summary: This study identified Eubacterium callanderi as a gut microbiota strain with anti-colorectal cancer activity. The cell-free supernatant of E. callanderi demonstrated dose-dependent and cancer cell-specific antiproliferative activity. The active molecules in the supernatant were heat stable and protease insensitive, and high concentrations of butyrate were found to possess anticancer activity. Ethyl acetate-extracted cell-free supernatant and 4-aminobutanoic acid were suggested to have potential anti-CRC effects. In a mouse model, oral administration of E. callanderi and peri-tumoral injection of the cell-free supernatant inhibited tumor growth. These findings suggest that E. callanderi could be a potential candidate for developing probiotics for colorectal cancer control.
MICROBIOLOGY SPECTRUM
(2022)
Review
Microbiology
Kai Xia, Renyuan Gao, Lin Li, Xiaocai Wu, Tianqi Wu, Yu Ruan, Lu Yin, Chunqiu Chen
Summary: Intestinal inflammation caused by gut microbiota plays a crucial role in promoting colorectal cancer, particularly in colitis-associated CRC. This review focuses on exploring the potential correlations between gut microbiota and colitis-associated CRC, as well as discussing promising microbiota-based strategies such as probiotics, prebiotics, microbiota-derived metabolites, and fecal microbiota transplantation.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Immunology
Wenwen Zhu, Jia Li, Yujie Chen, Zhuo Liu, Qingyu Zhang, Chunsheng Kang
Summary: AC1Q3QWB (AQB) exhibits potent antitumor activity against colorectal cancer in vivo, possibly by modulating the immune system and altering the intestinal microbiota.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
J. Xing, Y. Fang, W. Zhang, H. Zhang, D. Tang, D. Wang
Summary: Colorectal cancer is a heterogeneous disease of the intestinal epithelium and its high risk is believed to be related to the formation of biofilms. In this study, a bacterial driver-passenger model was introduced to explore the role of microorganisms in CRC development. Bacterial drivers initiate CRC formation through genotoxicity, while bacterial passengers maintain the CRC process through metabolites. Strategies to inhibit and eradicate pathogenic biofilms are explored to find new approaches for hindering colorectal carcinogenesis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Daotong Li, Yu Feng, Meiling Tian, Xiaosong Hu, Ruimao Zheng, Fang Chen
Summary: The study found that barley leaf supplementation can prevent colorectal cancer by reducing weight loss, inhibiting tumor formation, improving tissue damage, reducing cell proliferation and gene expression levels, and promoting the enrichment of Bifidobacterium.
Article
Gastroenterology & Hepatology
Daniel F. Zegarra Ruiz, Dasom V. Kim, Kendra Norwood, Fatima B. Saldana-Morales, Myunghoo Kim, Charles Ng, Ryann Callaghan, Maisha Uddin, Lin-Chun Chang, Randy S. Longman, Gretchen E. Diehl
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease that affects approximately 2 million Americans. This study found that using certain intestinal microbes can improve intestinal inflammation and restrict tumor formation. Macrophage-produced IL-10 and IL-10 signaling to the intestinal epithelium play important roles in both inflammation and tumor development.
Article
Multidisciplinary Sciences
Huixia Wu, Zhengchun Wu, Yilan Qiu, Fangjian Zhao, Minjing Liao, Zhihong Zhong, Jian Chen, Yiliang Zeng, Rushi Liu
Summary: This study found that a specific synbiotic intervention can protect the intestinal barrier, inhibit the occurrence of colitis-associated cancer (CAC), and improve the intestinal microecological environment. The synbiotic upregulates tight junction proteins and anti-inflammatory cytokines, while downregulating pro-inflammatory cytokines. It also improves the disorder of the colonic microbiota, promotes the formation of SCFAs and the production of secondary bile acids, and alleviates the accumulation of primary bile acids in CAC mice. Additionally, it inhibits the abnormal activation of the intestinal Wnt/β-catenin signaling pathway related to IL-23.
Article
Gastroenterology & Hepatology
Aonghus Lavelle, Stephane Nancey, Jean-Marie Reimund, David Laharie, Philippe Marteau, Xavier Treton, Matthieu Allez, Xavier Roblin, Georgia Malamut, Cyriane Oeuvray, Nathalie Rolhion, Xavier Dray, Dominique Rainteau, Antonin Lamaziere, Emilie Gauliard, Julien Kirchgesner, Laurent Beaugerie, Philippe Seksik, Laurent Peyrin-Biroulet, Harry Sokol
Summary: This study investigated the association between gut microbiota, bile acids, and colorectal cancer in IBD patients. The results found that specific bacterial taxa were associated with cancer, while bile acids were not. Additionally, clustering analysis identified microbiota clusters associated with clinical features.
Article
Immunology
Wenfeng Pu, Hong Zhang, Tao Zhang, Xiaoguang Guo, Xiaoqing Wang, Shaohui Tang
Summary: This study found that both the culture and supernatant of Clostridium butyricum (CB) could inhibit the development and progression of inflammatory colorectal cancer (CRC) in mice induced by AOM+DSS, possibly due to the high levels of butyric acid in the supernatant and the regulation of the NF-kappa B/p65 pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Kazukuni Hayashi, Hans-Juergen Busse, Jan Golke, James Anderson, Xuehua Wan, Shaobin Hou, Patrick S. G. Chain, Rebecca D. Prescott, Stuart P. Donachie
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Kent Koster, Angela Largen, Jeffrey T. Foster, Kevin P. Drees, Lishi Qian, Edward P. Desmond, Xuehua Wan, Shaobin Hou, James T. Douglas
Article
Biochemistry & Molecular Biology
Xuehua Wan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Microbiology
Hao Sun, Yajun Song, Fang Chen, Changhong Zhou, Peng Liu, Yu Fan, Yangyang Zheng, Xuehua Wan, Lu Feng
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Biology
Mingqing Zhang, Yongming Lv, Shaobin Hou, Yanfei Liu, Yijia Wang, Xuehua Wan
Summary: This study investigated the gut microbiota composition and structure across different stages of colorectal cancer, identifying specific bacterial taxa as potential biomarkers for tumor initiation and progression. The findings suggest stage-specific roles of certain bacteria in driving colorectal cancer progression, providing a reference index for stage-specific diagnosis.
Article
Biology
Xuehua Wan, Jennifer A. Saito, Shaobin Hou, Scott M. Geib, Anton Yuryev, Lynne M. Higa, Christopher Z. Womersley, Maqsudul Alam
Summary: Wan et al. investigated the genome and transcriptome of Aphelenchus avenae, a nematode capable of enduring long-term extreme desiccation. They compared gene features with eight other nematode species, identifying intrinsically disordered proteins and gene expression changes that contribute to the adaptation to anhydrobiosis.
COMMUNICATIONS BIOLOGY
(2021)
Correction
Biology
Xuehua Wan, Jennifer A. Saito, Shaobin Hou, Scott M. Geib, Anton Yuryev, Lynne M. Higa, Christopher Z. Womersley, Maqsudul Alam
COMMUNICATIONS BIOLOGY
(2021)
Article
Agricultural Engineering
Shenmei Sun, Xiaoru Song, Ya Bian, Xuehua Wan, Jingjing Zhang, Wei Wang
Summary: This study comprehensively optimized important factors affecting the application of engineered Geobacillus for nitroalkanes degradation. The deep-reconstructed engineered strains significantly raised the expression and activity level of catalytic enzymes, and further debugging of key parameters effectively improved their performance. A low-cost and highly effective bioreactor test proved the effectiveness of the multi-parameter optimization mode for genetically engineered bacteria.
BIORESOURCE TECHNOLOGY
(2022)
Article
Engineering, Environmental
Chenchen Peng, Xuehua Wan, Jingjing Zhang, Bingling Zhang, Shuo Wang, Ting Ma, Ya Bian, Wei Wang
Summary: Oil refining waste (ORW) contains complex, hazardous, and refractory components. This study investigates the degradation of ORW using acclimated bacteria from oily sludges and polymer-flooding wastewater. The results show that oxygen and temperature play key roles in ORW degradation, with higher biomass and biodiversity promoting rapid and multi-component degradation. Dominant genera with oxygen-independent sustainable degradation ability are identified as promising bioremediation candidates.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Gastroenterology & Hepatology
Rui-Xue Huo, Yi-Jia Wang, Shao-Bin Hou, Wei Wang, Chun-Ze Zhang, Xue-Hua Wan
Summary: This study investigates the relationship between gut mucosal microbiota profiles and colorectal cancer (CRC) recurrence and patient prognosis. The researchers found spatial-specific patterns of gut mucosal microbiota profiles linked to CRC recurrence and patient prognosis. 17 bacterial genera/families were identified as potential biomarkers for CRC recurrence and patient prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Hao Sun, Xuehua Wan, Yu Fan, Peng Liu, Yajun Song, Ningyu Zhu, Zhifeng Duan, Qian Wang, Fang Chen, Changhong Zhou, Yangyang Zheng, Peng Ding, Fenxia Liu, Lu Feng, Kwang Sik Kim, Lei Wang
Summary: The immune response of brain cells to invading bacteria and the mechanism used by pathogenic bacteria to escape immune surveillance in the brain are still not well understood. Microglia can engulf pathogenic bacteria and activate astrocytes to produce C3 for antibacterial activity. Pathogenic bacteria can sense low concentration of threonine in cerebrospinal fluid to reduce the immune response.
Article
Engineering, Environmental
Shenmei Sun, Xuehua Wan, Ya Bian, Shuo Wang, Jingjing Zhang, Wei Wang
Summary: Highly efficient phenol catalytic patterns were identified in Parageobacillus thermoglucosidasius W-36, which exhibited superior degradation performance compared to P. thermoglucosidasius W-2 with a single-pathway pattern. An exogenous degradation pathway was obtained through horizontal gene transfer, having distinct three-dimensional structures and substrate-binding sites from isofunctional enzymes. The dual-pathway pattern was time-dependently expressed in response to substrate levels, providing strain adaptability to high-concentration phenol. Evolutionary analysis suggested that the single/dual-pathway patterns may be a natural selection phenomenon caused by high-concentration phenol.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Chenchen Peng, Yukun Shi, Shuo Wang, Jingjing Zhang, Xuehua Wan, Yalin Yin, Dongxu Wang, Wei Wang
Summary: This study identified a unique thermophilic bacterium, Parageobacillus thermoglucosidasius W-36, with the ability to desulfurize waste oil residues and tolerate multiple hazardous organosulfur pollutants. Multiple desulfurization systems were found through genome information mining. Enzymatic characterization, phylogenetic relationships, transcriptional performance, and structural prediction indicated four novel key monooxygenases for diverse organosulfur removal. This work demonstrates the potential of genetic engineering for broad-spectrum hazardous organosulfur removal and the application potential of thermophilic bacteria as a promising alternative for waste residue oil cleaning through biodesulfurization.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Oncology
Yijia Wang, Chunze Zhang, Shaobin Hou, Xiaojing Wu, Jun Liu, Xuehua Wan
CANCER MANAGEMENT AND RESEARCH
(2020)