标题
Microglia: Immune and non-immune functions
作者
关键词
-
出版物
IMMUNITY
Volume 54, Issue 10, Pages 2194-2208
出版商
Elsevier BV
发表日期
2021-10-13
DOI
10.1016/j.immuni.2021.09.014
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
- (2021) Mehrnoosh Jafari et al. NATURE NEUROSCIENCE
- Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
- (2021) Akira Sobue et al. Acta Neuropathologica Communications
- Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease
- (2021) Emma Gerrits et al. ACTA NEUROPATHOLOGICA
- Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation
- (2021) Marco Prinz et al. Annual Review of Immunology
- Proteogenomic and metabolomic characterization of human glioblastoma
- (2021) Liang-Bo Wang et al. CANCER CELL
- Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling
- (2021) Peter Wieghofer et al. EMBO JOURNAL
- Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia
- (2021) Yifei Dong et al. NATURE NEUROSCIENCE
- Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease
- (2021) Sudha R. Guttikonda et al. NATURE NEUROSCIENCE
- Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
- (2021) Natalia Ochocka et al. Nature Communications
- Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination
- (2021) Kimberle Shen et al. Cell Reports
- Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
- (2021) Ester Gangoso et al. CELL
- Microglia use TAM receptors to detect and engulf amyloid β plaques
- (2021) Youtong Huang et al. NATURE IMMUNOLOGY
- Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
- (2021) Ana Rita Pombo Antunes et al. NATURE NEUROSCIENCE
- Barcoded viral tracing of single-cell interactions in central nervous system inflammation
- (2021) Iain C. Clark et al. SCIENCE
- Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
- (2021) Xin Ding et al. Nature Communications
- Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes
- (2021) Paul S. Baxter et al. Cell Reports
- Microglia provide structural resolution to injured dendrites after severe seizures
- (2021) Ukpong B. Eyo et al. Cell Reports
- Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival
- (2021) Baoying Cheng et al. Frontiers in Immunology
- Macrophages and microglia: the cerberus of glioblastoma
- (2021) Alice Buonfiglioli et al. Acta Neuropathologica Communications
- Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions
- (2021) Marius Schwabenland et al. IMMUNITY
- Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
- (2021) Cameron S. McAlpine et al. NATURE
- Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth
- (2020) Maojin Yao et al. CELL
- TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
- (2020) Alicia A. Nugent et al. NEURON
- Microglia mediate forgetting via complement-dependent synaptic elimination
- (2020) Chao Wang et al. SCIENCE
- Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology
- (2020) Alma Nazlie Mohebiany et al. Cell Reports
- Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb
- (2020) Jenelle Wallace et al. eLife
- Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes
- (2020) Ekaterina Friebel et al. CELL
- Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells
- (2020) Florian Klemm et al. CELL
- A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
- (2020) Tao Li et al. EMBO JOURNAL
- Transcriptomic profiling of microglia and astrocytes throughout aging
- (2020) Jie Pan et al. Journal of Neuroinflammation
- Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
- (2020) Phi T. Nguyen et al. CELL
- Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
- (2020) Emanuela Pasciuto et al. CELL
- Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
- (2020) Nicole Scott‐Hewitt et al. EMBO JOURNAL
- Novel Hexb-based tools for studying microglia in the CNS
- (2020) Takahiro Masuda et al. NATURE IMMUNOLOGY
- Human fetal microglia acquire homeostatic immune-sensing properties early in development
- (2020) L. Kracht et al. SCIENCE
- Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance
- (2020) Leila Akkari et al. Science Translational Medicine
- Mouse Astrocytes Promote Microglial Ramification by Releasing TGF-β and Forming Glial Fibers
- (2020) Jinqiang Zhang et al. Frontiers in Cellular Neuroscience
- Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo
- (2020) Eyiyemisi C. Damisah et al. Science Advances
- T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection
- (2020) E. Ashley Moseman et al. Science Immunology
- Overexpression of the ubiquitin‐editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation
- (2020) Perga Simona et al. BRAIN PATHOLOGY
- Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge
- (2020) Anat Shemer et al. IMMUNITY
- Negative feedback control of neuronal activity by microglia
- (2020) Ana Badimon et al. NATURE
- Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism
- (2020) Lucas Cheadle et al. NEURON
- Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia
- (2020) Jing Wang et al. NEURON
- Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?
- (2020) Shane A. Liddelow et al. TRENDS IN IMMUNOLOGY
- Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination
- (2020) Ashley D. Nemes-Baran et al. Cell Reports
- A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages
- (2020) Jung-Seok Kim et al. IMMUNITY
- Microglial Gi-dependent dynamics regulate brain network hyperexcitability
- (2020) Mario Merlini et al. NATURE NEUROSCIENCE
- Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
- (2020) Stefan A. Berghoff et al. NATURE NEUROSCIENCE
- Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease
- (2020) Maria L. Allende et al. CELLULAR SIGNALLING
- Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation
- (2019) Michael A. Wheeler et al. CELL
- Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation
- (2019) Shin-ichi Kano et al. Science Signaling
- Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
- (2019) Marta Joana Costa Jordão et al. SCIENCE
- Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
- (2019) Takahiro Masuda et al. NATURE
- Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration
- (2019) Emily G. O’Koren et al. IMMUNITY
- Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β
- (2019) Juliana Komuczki et al. IMMUNITY
- Single-cell transcriptomic analysis of Alzheimer’s disease
- (2019) Hansruedi Mathys et al. NATURE
- A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
- (2019) Hannah Van Hove et al. NATURE NEUROSCIENCE
- Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell–specific chemokine recruitment of T cells and microglia
- (2019) Xiaofan Guo et al. NEURO-ONCOLOGY
- Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice
- (2019) Liang Sheng et al. FASEB JOURNAL
- CSF-1 controls cerebellar microglia and is required for motor function and social interaction
- (2019) Veronika Kana et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neuronal vulnerability and multilineage diversity in multiple sclerosis
- (2019) Lucas Schirmer et al. NATURE
- GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis
- (2019) Edoardo Galli et al. NATURE MEDICINE
- T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses
- (2019) Charise Garber et al. NATURE NEUROSCIENCE
- Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
- (2019) Georgia Gunner et al. NATURE NEUROSCIENCE
- The pro-remyelination properties of microglia in the central nervous system
- (2019) Amy F. Lloyd et al. Nature Reviews Neurology
- Macrophages at CNS interfaces: ontogeny and function in health and disease
- (2019) Katrin Kierdorf et al. NATURE REVIEWS NEUROSCIENCE
- Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice
- (2019) Karin Steinbach et al. Science Translational Medicine
- The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
- (2019) D Garrett Brown et al. eLife
- Microglia: Same same, but different
- (2019) Katrin Kierdorf et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Microglia Biology: One Century of Evolving Concepts
- (2019) Marco Prinz et al. CELL
- Mapping microglia states in the human brain through the integration of high-dimensional techniques
- (2019) Roman Sankowski et al. NATURE NEUROSCIENCE
- Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling
- (2019) Yong U. Liu et al. NATURE NEUROSCIENCE
- Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex
- (2019) Rianne D. Stowell et al. NATURE NEUROSCIENCE
- TET2 Regulates the Neuroinflammatory Response in Microglia
- (2019) Alejandro Carrillo-Jimenez et al. Cell Reports
- Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
- (2019) Chun-Cheih Chao et al. CELL
- Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease
- (2019) Sebastian Werneburg et al. IMMUNITY
- Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
- (2019) Csaba Cserép et al. SCIENCE
- Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms
- (2018) Rebeka Fekete et al. ACTA NEUROPATHOLOGICA
- Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone-induced demyelination
- (2018) Yochai Wolf et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
- (2018) Dunja Mrdjen et al. IMMUNITY
- Microglia are required for protection against lethal coronavirus encephalitis in mice
- (2018) D. Lori Wheeler et al. JOURNAL OF CLINICAL INVESTIGATION
- Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury
- (2018) Geoffrey T. Norris et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Microglial control of astrocytes in response to microbial metabolites
- (2018) Veit Rothhammer et al. NATURE
- Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models
- (2018) Bahareh Ajami et al. NATURE NEUROSCIENCE
- Epigenetic regulation of brain region-specific microglia clearance activity
- (2018) Pinar Ayata et al. NATURE NEUROSCIENCE
- A Combination of Ontogeny and CNS Environment Establishes Microglial Identity
- (2018) F. Chris Bennett et al. NEURON
- Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation
- (2018) Mithilesh Kumar Jha et al. NEUROSCIENTIST
- Defective cholesterol clearance limits remyelination in the aged central nervous system
- (2018) Ludovico Cantuti-Castelvetri et al. SCIENCE
- Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
- (2018) Ilia D. Vainchtein et al. SCIENCE
- A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
- (2018) Sofie Voet et al. Nature Communications
- Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
- (2018) Laetitia Weinhard et al. Nature Communications
- The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions
- (2018) Ukpong B. Eyo et al. Scientific Reports
- Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945
- (2018) Nicolau Beckmann et al. Acta Neuropathologica Communications
- Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage
- (2018) Inken Waltl et al. BRAIN BEHAVIOR AND IMMUNITY
- Spatial impact of microglial distribution on dynamics of dendritic spines
- (2018) Tadatsune Iida et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
- (2018) Timothy R. Hammond et al. IMMUNITY
- Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry
- (2018) Chotima Böttcher et al. NATURE NEUROSCIENCE
- Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
- (2018) Samira Parhizkar et al. NATURE NEUROSCIENCE
- CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development
- (2018) Emily K. Lehrman et al. NEURON
- Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing
- (2018) Qingyun Li et al. NEURON
- Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis
- (2018) Chintan Chhatbar et al. Cell Reports
- Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function
- (2017) Kazuyuki Takata et al. IMMUNITY
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microglia
- (2017) Filip Petković et al. JOURNAL OF NEUROIMMUNOLOGY
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Cell-type-specific metabolic labeling of nascent proteomes in vivo
- (2017) Beatriz Alvarez-Castelao et al. NATURE BIOTECHNOLOGY
- The role of peripheral immune cells in the CNS in steady state and disease
- (2017) Marco Prinz et al. NATURE NEUROSCIENCE
- Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging
- (2017) Petra Füger et al. NATURE NEUROSCIENCE
- A new fate mapping system reveals context-dependent random or clonal expansion of microglia
- (2017) Tuan Leng Tay et al. NATURE NEUROSCIENCE
- iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
- (2017) Edsel M. Abud et al. NEURON
- Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
- (2017) Christopher J. Bohlen et al. NEURON
- Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas
- (2017) D Yan et al. ONCOGENE
- An environment-dependent transcriptional network specifies human microglia identity
- (2017) David Gosselin et al. SCIENCE
- Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma
- (2017) Spyros Darmanis et al. Cell Reports
- Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
- (2017) Lilach Soreq et al. Cell Reports
- The Lifespan and Turnover of Microglia in the Human Brain
- (2017) Pedro Réu et al. Cell Reports
- Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
- (2017) Katharine Askew et al. Cell Reports
- Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
- (2017) Han Gao et al. Cell Reports
- Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation
- (2016) Filip Petković et al. GLIA
- Tissue-Resident Macrophage Ontogeny and Homeostasis
- (2016) Florent Ginhoux et al. IMMUNITY
- A complement–microglial axis drives synapse loss during virus-induced memory impairment
- (2016) Michael J. Vasek et al. NATURE
- TAM receptors regulate multiple features of microglial physiology
- (2016) Lawrence Fourgeaud et al. NATURE
- Age-related myelin degradation burdens the clearance function of microglia during aging
- (2016) Shima Safaiyan et al. NATURE NEUROSCIENCE
- Specification of tissue-resident macrophages during organogenesis
- (2016) E. Mass et al. SCIENCE
- The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
- (2016) D. F. Quail et al. SCIENCE
- Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
- (2016) Robert L. Bowman et al. Cell Reports
- TREM2 regulates microglial cell activation in response to demyelination in vivo
- (2015) Claudia Cantoni et al. ACTA NEUROPATHOLOGICA
- TREM2 sustains microglial expansion during aging and response to demyelination
- (2015) Pietro Luigi Poliani et al. JOURNAL OF CLINICAL INVESTIGATION
- Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities
- (2014) David Gosselin et al. CELL
- Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
- (2014) Monica R.P. Elmore et al. NEURON
- Role of Microglia in CNS Autoimmunity
- (2013) Tobias Goldmann et al. Clinical & Developmental Immunology
- A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
- (2013) Tobias Goldmann et al. NATURE NEUROSCIENCE
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
- (2013) Veronique E Miron et al. NATURE NEUROSCIENCE
- Bone Marrow Cell Recruitment to the Brain in the Absence of Irradiation or Parabiosis Bias
- (2013) Katrin Kierdorf et al. PLoS One
- Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia
- (2012) Melanie Greter et al. IMMUNITY
- A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
- (2012) C. Schulz et al. SCIENCE
- Identification of a microglia phenotype supportive of remyelination
- (2011) Marta Olah et al. GLIA
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
- (2010) F. Ginhoux et al. SCIENCE
- The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting
- (2008) Jeffrey A. Winkles NATURE REVIEWS DRUG DISCOVERY
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