Viral mediated knockdown of GATA6 in SMA iPSC ‐derived astrocytes prevents motor neuron loss and microglial activation

Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

(2021) Anna M. Klawonn et al.   IMMUNITY

Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit

(2021) Meaghan Van Alstyne et al.   NATURE NEUROSCIENCE

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

(2021) Jong-Sung Park et al.   Acta Neuropathologica Communications

Assessment of cerebral spinal fluid biomarkers and microRNA-mediated disease mechanisms in spinal muscular atrophy patient samples

(2021) Emily Welby et al.   HUMAN MOLECULAR GENETICS

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

New and Developing Therapies in Spinal Muscular Atrophy: From Genotype to Phenotype to Treatment and Where Do We Stand?

(2020) Tai-Heng Chen   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

(2020) Julie C. Savage et al.   Journal of Neuroinflammation

Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery

(2020) Vincent Soubannier et al.   NEUROSCIENCE LETTERS

Crosstalk Between Astrocytes and Microglia: An Overview

(2020) Agata Matejuk et al.   Frontiers in Immunology

Generation of Functional Human 3D Cortico-Motor Assembloids

(2020) Jimena Andersen et al.   CELL

Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models

(2020) Hannah Franklin et al.   PROGRESS IN NEUROBIOLOGY

AAV9 Vector: a Novel modality in gene therapy for spinal muscular atrophy

(2019) Rithu Pattali et al.   GENE THERAPY

Astrocytes: Role and Functions in Brain Pathologies

(2019) Rosalba Siracusa et al.   Frontiers in Pharmacology

Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders

(2019) Samuel F. Yanuck   Frontiers in Psychiatry

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

(2019) Sebastian Werneburg et al.   IMMUNITY

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

(2019) Aleksandra Vukojicic et al.   Cell Reports

ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?

(2019) Rita Mejzini et al.   Frontiers in Neuroscience

Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism

(2018) Praveen Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of survival motor neuron protein (SMN) in protein homeostasis

(2018) Helena Chaytow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

(2018) Christian Hinderer et al.   HUMAN GENE THERAPY

Glial Activation and Central Synapse Loss, but Not Motoneuron Degeneration, Are Prevented by the Sigma-1 Receptor Agonist PRE-084 in the Smn2B/− Mouse Model of Spinal Muscular Atrophy

(2018) Clàudia Cerveró et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function

(2018) Kathryn M. Lenz et al.   Frontiers in Immunology

Intracortical astrocyte subpopulations defined by astrocyte reporter Mice in the adult brain

(2018) Lydie Morel et al.   GLIA

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines

(2018) Sylvain Perriot et al.   Stem Cell Reports

Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy

(2017) Samantha L. Sison et al.   HUMAN MOLECULAR GENETICS

Decreased Motor Neuron Support by SMA Astrocytes due to Diminished MCP1 Secretion

(2017) Jasmin E. Martin et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

(2017) Julia TCW et al.   Stem Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

(2017) Benjamin M. Davis et al.   Scientific Reports

Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss

(2017) Sheri L. Peterson et al.   Scientific Reports

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy

(2016) Chung-Wei Yang et al.   PLoS One

SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons

(2015) Teresa N. Patitucci et al.   HUMAN MOLECULAR GENETICS

Astrocytes influence the severity of spinal muscular atrophy

(2015) Hansjörg Rindt et al.   HUMAN MOLECULAR GENETICS

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

(2015) Lyndsay M. Murray et al.   Acta Neuropathologica Communications

Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons

(2014) Hong Chen et al.   Cell Stem Cell

Mechanisms Involved in Spinal Cord Central Synapse Loss in a Mouse Model of Spinal Muscular Atrophy

(2014) Olga Tarabal et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes

(2014) Yves Maury et al.   NATURE BIOTECHNOLOGY

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production

(2013) Jered V. McGivern et al.   GLIA

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

(2013) Laurent Roybon et al.   Cell Reports

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron Dysfunction

(2012) R. G. Gogliotti et al.   JOURNAL OF NEUROSCIENCE

Survival Motor Neuron Protein in Motor Neurons Determines Synaptic Integrity in Spinal Muscular Atrophy

(2012) T. L. Martinez et al.   JOURNAL OF NEUROSCIENCE

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

(2012) M. Fricker et al.   JOURNAL OF NEUROSCIENCE

GATA-6 and NF- B Activate CPI-17 Gene Transcription and Regulate Ca2+ Sensitization of Smooth Muscle Contraction

(2012) E. Boopathi et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy

(2012) Dhruv Sareen et al.   PLoS One

Limited Phenotypic Effects of Selectively Augmenting the SMN Protein in the Neurons of a Mouse Model of Severe Spinal Muscular Atrophy

(2012) Andrew J-H. Lee et al.   PLoS One

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’

(2012) Guy C. Brown et al.   TRENDS IN BIOCHEMICAL SCIENCES

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy

(2011) J. N. Sleigh et al.   Disease Models & Mechanisms

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Complement upregulation and activation on motor neurons and neuromuscular junction in the SOD1 G93A mouse model of familial amyotrophic lateral sclerosis

(2011) Bianca Heurich et al.   JOURNAL OF NEUROIMMUNOLOGY

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

(2011) Yimin Hua et al.   NATURE

Spinal muscular atrophy

(2011) Adele D'Amico et al.   Orphanet Journal of Rare Diseases

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Reduced Survival of Motor Neuron (SMN) Protein in Motor Neuronal Progenitors Functions Cell Autonomously to Cause Spinal Muscular Atrophy in Model Mice Expressing the Human Centromeric (SMN2) Gene

(2010) G.-H. Park et al.   JOURNAL OF NEUROSCIENCE

Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy

(2010) Karen K. Y. Ling et al.   PLoS One

Role of Astrocytes in Brain Function and Disease

(2010) Marta Sidoryk-Wegrzynowicz et al.   TOXICOLOGIC PATHOLOGY

Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies

(2009) Masahiro Kondo et al.   IMMUNOLOGY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code

(2008) Christian Hochstim et al.   CELL

Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5

(2008) Joari De Miranda et al.   FASEB JOURNAL

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

(2008) Xuefei Wu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Spinal muscular atrophy

(2008) Maryam Oskoui et al.   Neurotherapeutics