ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes

Brown adipose tissue is associated with cardiometabolic health

(2021) Tobias Becher et al.   NATURE MEDICINE

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice

(2020) Chih-Hao Wang et al.   Science Translational Medicine

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

(2019) Wenxiang Hu et al.   Cell Stem Cell

Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation

(2019) William N. Addison et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism

(2019) Stephanie Pearson et al.   GENES & DEVELOPMENT

Cellular Origins of Beige Fat Cells Revisited

(2019) Mengle Shao et al.   DIABETES

Transcriptional brakes on the road to adipocyte thermogenesis

(2018) Mengle Shao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

(2018) Hyun Cheol Roh et al.   Cell Metabolism

De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

(2018) Mengle Shao et al.   Nature Communications

Transcriptional Control of Brown and Beige Fat Development and Function

(2018) Suzanne N. Shapira et al.   Obesity

EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex

(2017) Suzanne N. Shapira et al.   GENES & DEVELOPMENT

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome

(2017) Brian S Johnson et al.   NATURE MEDICINE

Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice

(2017) Chelsea Hepler et al.   eLife

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

(2016) Mengle Shao et al.   Cell Metabolism

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

(2016) Lavanya Vishvanath et al.   Cell Metabolism

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Control of brown and beige fat development

(2016) Wenshan Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

(2016) Rachel R. Stine et al.   Molecular Metabolism

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

(2015) Raymond E. Soccio et al.   CELL

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Structure and function insights into the NuRD chromatin remodeling complex

(2015) Morgan P. Torchy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cellular origins of cold-induced brown adipocytes in adult mice

(2015) Yun-Hee Lee et al.   FASEB JOURNAL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ebf2 is a selective marker of brown and beige adipogenic precursor cells

(2014) Wenshan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

(2013) Claudio J. Villanueva et al.   Cell Metabolism

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

Zfp423/OAZ Mutation Reveals the Importance of Olf/EBF Transcription Activity in Olfactory Neuronal Maturation

(2012) Y. A. Roby et al.   JOURNAL OF NEUROSCIENCE

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Identification and Characterization of a Promoter Cassette Conferring Adipocyte-Specific Gene Expression

(2010) Zhao V. Wang et al.   ENDOCRINOLOGY

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation

(2010) Dorothy Beckett et al.   PROTEIN SCIENCE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization

(2009) D. D. Sears et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA