Structure and function insights into the NuRD chromatin remodeling complex

Towards an understanding of the structure and function of MTA1

(2014) Christopher J. Millard et al.   CANCER AND METASTASIS REVIEWS

MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner

(2014) Rodrigo L. dos Santos et al.   Cell Stem Cell

Insight into the Architecture of the NuRD Complex

(2014) Saad S. M. Alqarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

(2013) O. M. Dovey et al.   BLOOD

Methylation-Dependent and -Independent Genomic Targeting Principles of the MBD Protein Family

(2013) Tuncay Baubec et al.   CELL

The NuRD architecture

(2013) Hillary F. Allen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Radiation-inducible protein RbAp48 contributes to radiosensitivity of cervical cancer cells

(2013) Lin Zheng et al.   GYNECOLOGIC ONCOLOGY

Probing the Dynamic Distribution of Bound States for Methylcytosine-binding Domains on DNA

(2013) Jason M. Cramer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

(2013) Benjamin E. L. Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Versatile DNA Recognition Ability of the Methyl-CpG Binding Domain of Methyl-CpG Binding Domain Protein 4

(2013) Junji Otani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

(2013) Christopher J. Millard et al.   MOLECULAR CELL

Deterministic direct reprogramming of somatic cells to pluripotency

(2013) Yoach Rais et al.   NATURE

The BAH domain of Rsc2 is a histone H3 binding domain

(2013) Anna L. Chambers et al.   NUCLEIC ACIDS RESEARCH

Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48

(2013) E. Pavlopoulos et al.   Science Translational Medicine

MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes

(2013) Takashi Shimbo et al.   PLoS Genetics

Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response

(2012) Dong-Hyun Lee et al.   EMBO JOURNAL

Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4

(2012) Rosa Morra et al.   FEBS LETTERS

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4

(2012) Aleksandra A. Watson et al.   JOURNAL OF MOLECULAR BIOLOGY

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

(2012) Alex J. Kuo et al.   NATURE

Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

(2012) Wei Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

(2012) Hideharu Hashimoto et al.   NUCLEIC ACIDS RESEARCH

Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics

(2012) Arne H. Smits et al.   NUCLEIC ACIDS RESEARCH

Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development

(2012) P. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression

(2012) C. A. Musselman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells

(2011) Ozlem Yildirim et al.   CELL

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

(2011) Robyn E. Mansfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence

(2011) J. Neel Scarsdale et al.   NUCLEIC ACIDS RESEARCH

HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells

(2011) Benjamin L. Kidder et al.   NUCLEIC ACIDS RESEARCH

p66 -MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex

(2011) M. N. Gnanapragasam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of WD40 domain proteins

(2011) Chao Xu et al.   Protein & Cell

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Emphasizing the positive: A role for histone deacetylases in transcriptional activation

(2010) Oliver M. Dovey et al.   CELL CYCLE

Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

(2010) Matthew LeBoeuf et al.   DEVELOPMENTAL CELL

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex

(2010) Sara Lejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulating the Regulators: The Post-Translational Code of Class I HDAC1 and HDAC2

(2010) Chiara V. Segré et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex

(2010) Cornelia G. Spruijt et al.   Molecular BioSystems

c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

(2010) Cristina Aguilera et al.   NATURE

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation

(2010) O. M. Dovey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications

(2009) Catherine A. Musselman et al.   BIOCHEMICAL JOURNAL

Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma

(2009) Junpei Yamaguchi et al.   CANCER SCIENCE

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Cyclin-Dependent Kinase Inhibitor p21 Is a Crucial Target for Histone Deacetylase 1 as a Regulator of Cellular Proliferation

(2009) G. Zupkovitz et al.   MOLECULAR AND CELLULAR BIOLOGY

Novel variants identified in methyl-CpG-binding domain genes in autistic individuals

(2009) Holly N. Cukier et al.   NEUROGENETICS

Switching of chromatin-remodelling complexes for oestrogen receptor-α

(2008) Maiko Okada et al.   EMBO REPORTS

Eaf1 Is the Platform for NuA4 Molecular Assembly That Evolutionarily Links Chromatin Acetylation to ATP-Dependent Exchange of Histone H2A Variants

(2008) A. Auger et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor α mediated gene expression

(2008) Amy L. Creekmore et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG

(2008) Kok Lian Ho et al.   MOLECULAR CELL

Mecp2-Null Mice Provide New Neuronal Targets for Rett Syndrome

(2008) Rocio G. Urdinguio et al.   PLoS One

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

(2008) Natalia V. Murzina et al.   STRUCTURE