CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice

CRISPR–Cas: a tool for cancer research and therapeutics

(2019) Hao Yin et al.   Nature Reviews Clinical Oncology

Advances in stem cell research and therapeutic development

(2019) Michele De Luca et al.   NATURE CELL BIOLOGY

Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients

(2018) Josefine Reber et al.   Cell Metabolism

CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency

(2018) Peng Liu et al.   Cell Stem Cell

Human pluripotent reprogramming with CRISPR activators

(2018) Jere Weltner et al.   Nature Communications

Brown Adipose Tissue—A Therapeutic Target in Obesity?

(2018) Paul Trayhurn   Frontiers in Physiology

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

(2017) Verónica Eisner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution ofUCP1using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

(2017) Qiantao Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

(2017) Morten Lundh et al.   Molecular Metabolism

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes

(2017) Rókus Kriszt et al.   Scientific Reports

The early metabolomic response of adipose tissue during acute cold exposure in mice

(2017) Xiyuan Lu et al.   Scientific Reports

Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management

(2016) Aleksandra Jankovic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

(2016) Joshua B. Black et al.   Cell Stem Cell

Hemoglobin S-nitrosylation plays an essential role in cardioprotection

(2016) Rongli Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators

(2016) Shu Wei et al.   Scientific Reports

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

Strategies to increase nitric oxide signalling in cardiovascular disease

(2015) Jon O. Lundberg et al.   NATURE REVIEWS DRUG DISCOVERY

Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia

(2015) Rongli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

(2015) Linda S. Hoffmann et al.   Nature Communications

Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway

(2014) Lee D. Roberts et al.   DIABETES

Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis

(2014) Chih-Hao Wang et al.   HUMAN MOLECULAR GENETICS

Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men

(2014) Denis P. Blondin et al.   JOURNAL OF PHYSIOLOGY-LONDON

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

Brown fat fuel utilization and thermogenesis

(2014) Kristy L. Townsend et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

(2013) N. A. Kearns et al.   DEVELOPMENT

Increased Oxygen Consumption in Human Adipose Tissue From the “Brown Adipose Tissue” Region

(2013) Guy H. E. J. Vijgen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Nitric oxide formationversusscavenging: the red blood cell balancing act

(2012) Benjamin Y. Owusu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Detecting brown adipose tissue activity with BOLD MRI in mice

(2012) Arjun Khanna et al.   MAGNETIC RESONANCE IN MEDICINE

Cold but not sympathomimetics activates human brown adipose tissue in vivo

(2012) A. M. Cypess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation

(2010) C De Palma et al.   CELL DEATH AND DIFFERENTIATION

Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice

(2010) Mattias Carlström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

(2008) Francis Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxic Vasodilation by Red Blood Cells

(2008) Diana L. Diesen et al.   CIRCULATION RESEARCH

The Metabolic Syndrome

(2008) Marc-Andre Cornier et al.   ENDOCRINE REVIEWS

Obesity reduces the bioavailability of nitric oxide in juveniles

(2008) H-J Gruber et al.   INTERNATIONAL JOURNAL OF OBESITY

Dietary l-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats

(2008) Wenjuan Jobgen et al.   JOURNAL OF NUTRITION

Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo

(2008) Susanne Neschen et al.   PHYSIOLOGICAL GENOMICS