Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor

Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis

(2020) Xi Zhang et al.   STRUCTURE

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS

(2019) Cristina Puchades et al.   Scientific Reports

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

(2019) Glenn R. Masson et al.   NATURE METHODS

Structural basis of the activation of type 1 insulin-like growth factor receptor

(2019) Jie Li et al.   Nature Communications

Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity

(2018) Arsalan S. Haqqani et al.   JOURNAL OF NEUROCHEMISTRY

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial

(2018) Roberto Giugliani et al.   Orphanet Journal of Rare Diseases

How ligand binds to the type 1 insulin-like growth factor receptor

(2018) Yibin Xu et al.   Nature Communications

A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis

(2018) Maria Ribecco-Lutkiewicz et al.   Scientific Reports

Hydrogen–Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin

(2018) Shaolong Zhu et al.   BIOCHEMISTRY

Emerging Technologies for Delivery of Biotherapeutics and Gene Therapy Across the Blood–Brain Barrier

(2018) Danica B. Stanimirovic et al.   BIODRUGS

Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse–Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse

(2017) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

ANG1005 for breast cancer brain metastases: correlation between 18F-FLT–PET after first cycle and MRI in response assessment

(2016) C. C. O’Sullivan et al.   BREAST CANCER RESEARCH AND TREATMENT

Convex accelerated maximum entropy reconstruction

(2016) Bradley Worley   JOURNAL OF MAGNETIC RESONANCE

Subrandom methods for multidimensional nonuniform sampling

(2016) Bradley Worley   JOURNAL OF MAGNETIC RESONANCE

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

(2016) S. Aday et al.   TRENDS IN BIOTECHNOLOGY

Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors

(2015) John G. Menting et al.   STRUCTURE

Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity

(2014) G. Qiang et al.   DIABETES

Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects

(2014) Haim Werner et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Insulin Receptor Antibody–Sulfamidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells

(2014) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Mass Spec Studio for Integrative Structural Biology

(2014) Martial Rey et al.   STRUCTURE

How IGF-1 activates its receptor

(2014) Jennifer M Kavran et al.   eLife

Epitope-Specific Mechanisms of IGF1R Inhibition by Ganitumab

(2013) Frank J. Calzone et al.   PLoS One

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth

(2012) Geraldine M. Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model

(2012) Sylvia Wagner et al.   PLoS One

A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys

(2012) Sachiko Ohshima-Hosoyama et al.   PLoS One

Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen /Deuterium-Exchange and Peptide Mass Mapping

(2011) Damian Houde et al.   STRUCTURE

Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties

(2009) Adam Doern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Restraining Expansion of the Peak Envelope in H/D Exchange-MS and Its Application in Detecting Perturbations of Protein Structure/Dynamics

(2008) Gordon W. Slysz et al.   ANALYTICAL CHEMISTRY

The Type 1 Insulin-Like Growth Factor Receptor Pathway

(2008) M. M. Chitnis et al.   CLINICAL CANCER RESEARCH