Pyrazolotriazines: Biological activities, synthetic strategies and recent developments
出版年份 2021 全文链接
标题
Pyrazolotriazines: Biological activities, synthetic strategies and recent developments
作者
关键词
Pyrazolotriazine, Biological activity, Synthesis, SAR, Drug design, Mechanism of action
出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 223, Issue -, Pages 113537
出版商
Elsevier BV
发表日期
2021-06-11
DOI
10.1016/j.ejmech.2021.113537
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Synthesis, Structural Characterization, and Biological Activity of New Pyrazolo[4,3-e][1,2,4]triazine Acyclonucleosides
- (2020) Mariusz Mojzych et al. MOLECULES
- Regioselective Fluorination of 7-Oxo-1,2,4-benzotriazines Using Selectfluor
- (2019) Styliana Mirallai et al. MOLECULES
- 3-Substituted Benzo[e][1,2,4]triazines: Synthesis and Electronic Effects of the C(3) Substituent
- (2019) Agnieszka Bodzioch et al. JOURNAL OF ORGANIC CHEMISTRY
- Metalated azolo[1,2,4]triazines. II. Generation, C(4)-substituent dependent stability and electrophile trapping of 7-lithiopyrazolo[5,1-c][1,2,4]triazines
- (2019) Sergey M. Ivanov et al. JOURNAL OF ORGANOMETALLIC CHEMISTRY
- Decarboxylation and electrophilic substitution in 3-tert-butyl-4-oxopyrazolo[5,1-c][1,2,4]triazines
- (2019) S. M. Ivanov et al. RUSSIAN CHEMICAL BULLETIN
- Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitors
- (2019) Khulood H. Oudah et al. BIOORGANIC CHEMISTRY
- Diastereoselective synthesis of 3-tert-butyl-3,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3,4-diyl dicarboxylates
- (2019) Sergey M. Ivanov et al. TETRAHEDRON LETTERS
- Pyrazolo[1,5-a][1,3,5]triazin-2-thioxo-4-ones derivatives as thymidine phosphorylase inhibitors: Structure, drug-like calculations and quantitative structure-activity relationships (QSAR) modeling
- (2019) Marwa Manachou et al. JOURNAL OF MOLECULAR STRUCTURE
- A new class of pyrazolo[5,1- c ][1,2,4]triazines as γ-aminobutyric type A (GABA A ) receptor subtype ligand: synthesis and pharmacological evaluation
- (2018) Gabriella Guerrini et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1- c ][1,2,4]triazine scaffold and their evaluation in H 2 O 2 -induced oxidative stress
- (2018) Mohammed Loubidi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Thermal Ring-Opening of Pyrazolo[3,4-d ][1,2,3]triazin-4-ones: An Experimental and Theoretical Study
- (2018) Juan P. Colomer et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Quinazoline and quinazolinone as important medicinal scaffolds: a comparative patent review (2011–2016)
- (2018) Abdul Hameed et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Enaminone Incorporating a Dibromobenzofuran Moiety: Versatile Precursor for Novel Azines and Azolotriazines
- (2018) Sherif M. H. Sanad et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Biologically active azolo-1,2,4-triazines and azolopyrimidines
- (2018) V. L. Rusinov et al. RUSSIAN CHEMICAL BULLETIN
- Unexpected Reaction of Ethyl 4-(Chloromethyl)pyrazolo- [5,1-c][1,2,4]triazine-3-carboxylates with Thiourea and Its Mechanism
- (2018) I. V. Ledenyova et al. RUSSIAN JOURNAL OF GENERAL CHEMISTRY
- Novel Pyrazolo[1,5-a ]Pyrimidines and Pyrazolo[5,1-c ][1,2,4]Triazines Incorporating Indole Moiety as a New Class of Antioxidant Agents
- (2018) Ahmed El-Mekabaty et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Synthesis and Acaricidal Activity of Some New 1,2,4‐Triazine Derivatives
- (2018) Wafaa S. Hamama et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Synthetic procedure to pyrido[2,1-f][1,2,4]triazinium salt and related compounds
- (2018) Sándor Bátori et al. TETRAHEDRON
- Synthesis, antitumor evaluation and microarray study of some new pyrazolo[3,4- d ][1,2,3]triazine derivatives
- (2017) Tamer Nasr et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of Pyrazolo[1,5-a ][1,3,5]triazine, Pyrazolo[1,5-a ]pyrimidine, and Imidazo[1,2-b ]pyrazole Derivatives Based on Imidazo[2,1-b ]thiazole Moiety
- (2017) Kamal M. Dawood et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- 1-Morpholino-2-nitroethylene as a precursor of nitroacetaldehyde in the synthesis of azolo[5,1- c ][1,2,4]triazines
- (2017) Egor K. Voinkov et al. MENDELEEV COMMUNICATIONS
- Synthesis, dyeing performance on polyester fiber and antimicrobial studies of some novel pyrazolotriazine and pyrazolyl pyrazolone azo dyes
- (2017) Hala F. Rizk et al. Arabian Journal of Chemistry
- Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues
- (2017) Reda M. Abdel-Rahman et al. Journal of Saudi Chemical Society
- Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK
- (2016) Radoslaw Laufer et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis of chiral pyrazolo[4,3-e][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity
- (2016) Mariusz Mojzych et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- The Top 5 Neurotransmitters from a Clinical Neurologist’s Perspective
- (2016) Daniel Kondziella NEUROCHEMICAL RESEARCH
- 4-Aryl-3-(methanesulfonyl)pyrazolo[5,1-c][1,2,4]triazines and their transformations
- (2016) I. V. Ledenyova et al. RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
- New pyrazolo[4,3- e ][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors
- (2015) Mariusz Mojzych et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pyrazoloquinazolines: Synthetic strategies and bioactivities
- (2015) Mansi Garg et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Purine and Guanine Thioglycoside Analogs: Novel Synthesis of a New Class of Pyrazolo[1,5-a][1,3,5]Triazine-4-Thioglycoside Derivatives under Microwave Activation
- (2015) Galal Elgemeie et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Synthesis of pyrazolo[4,3- e ][1,2,4]triazine sulfonamides, novel Sildenafil analogs with tyrosinase inhibitory activity
- (2014) Mariusz Mojzych et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Anticonvulsant profile of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine
- (2014) Martín Hermógenes Estrada et al. Brazilian Journal of Pharmaceutical Sciences
- Purine nucleoside phosphorylase and xanthine oxidase activities in erythrocytes and plasma from marine, semiaquatic and terrestrial mammals
- (2014) Roberto I. López-Cruz et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
- Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines
- (2014) Mariusz Mojzych et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Facile Route to Novel Pyrazolo[3,4-d]pyrimidine, Imidazo[1,2-b] pyrazole, Pyrazolo[3,4-d][1,2,3]triazine, Pyrazolo[1,5-c][1,3,5]triazine and Pyrazolo[1,5-c][1,3,5]thiadiazine Derivatives
- (2014) Samir Bondock et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Pyrazolo[1,5-a]-1,3,5-triazine C-Nucleoside as Deoxyadenosine Analogue: Synthesis, Pairing, and Resistance to Hydrolysis
- (2014) Myriam Lefoix et al. JOURNAL OF ORGANIC CHEMISTRY
- Azo-coupling of pyrazole-3(5)-diazonium chlorides with cyanothioacetamide: a convenient synthesis of pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides
- (2014) Irina V. Ledenyova et al. TETRAHEDRON LETTERS
- 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
- (2014) Felicia Phei Lin Lim et al. TETRAHEDRON LETTERS
- Synthesis and absorption abilities of pyrazolo[5,1-c][1,2,4]triazine-based disperse dyes
- (2013) F. Karcı et al. Chemistry of Heterocyclic Compounds
- Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors
- (2013) Lingyi Sun et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase
- (2013) Lingyi Sun et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles
- (2013) Wedad M. Al-Adiwish et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines
- (2012) Henry Insuasty et al. TETRAHEDRON
- New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor
- (2011) Gabriella Guerrini et al. BIOORGANIC & MEDICINAL CHEMISTRY
- New application of heterocyclic diazonium salts. Synthesis of pyrazolo[3,4-d][1,2,3]triazin-4-ones and imidazo[4,5-d][1,2,3]triazin-4-ones
- (2011) Juan Pablo Colomer et al. TETRAHEDRON LETTERS
- Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines
- (2010) Tomáš Gucký et al. MONATSHEFTE FUR CHEMIE
- Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives
- (2009) Florence Popowycz et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A DFT investigation of structure and spectroscopic properties of pyrazolo[4,3-e][1,2,4]triazine natural products
- (2009) V. Galasso CHEMICAL PHYSICS LETTERS
- 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists
- (2009) Paul J. Gilligan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pyrazolo[1,5-a]-1,3,5-triazine as a Purine Bioisostere: Access to Potent Cyclin-Dependent Kinase Inhibitor (R)-Roscovitine Analogue
- (2009) Florence Popowycz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Docking and 3D QSAR studies of protoporphyrinogen oxidase inhibitor 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives
- (2009) Kunal Roy et al. JOURNAL OF MOLECULAR MODELING
- In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor 5 Subtype-Selective Inverse Agonist
- (2009) J. R. Atack et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Azolo[5,1-c]-1,2,4-triazines as a new class of antiviral compounds
- (2009) V. L. Rusinov et al. RUSSIAN CHEMICAL BULLETIN
- Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines
- (2008) Tomáš Gucký et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- New Application of Heterocyclic Diazonium Salts: Synthesis of New Pyrazolo[3,4‐d][1,2,3]triazin‐4‐ones
- (2008) Elizabeth L. Moyano et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities
- (2007) Zhe Nie et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Cyclic nucleotide phosphodiesterase type 4 inhibitors: Evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere
- (2007) Pierre Raboisson et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now