期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 2, 页码 891-900出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2008.05.026
关键词
Pyrazolo[4,3-e][1,2,4]triazines; Cytotoxic activity
资金
- Ministry of Education, Youth and Sport of the Czech Republic [MSM6198959216]
A series of the 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines (17a-20f) have been synthesized in five steps. The cytotoxic activity of all of the newly synthesized compounds has been tested in vitro against five cancer cell lines. Several compounds demonstrated significant broad cytotoxic activity in low micromolar range, while others were selectively active against lung adenocarcinoma cell line A549. (c) 2008 Elsevier Masson SAS. All rights reserved.
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