期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 9, 页码 3471-3478出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.03.007
关键词
Myoseverin; Pyrazolo[1,5-a]-1,3,5-triazine; Tubulin; Cancer
资金
- Association pour la Recherche sur le Cancer (ARC) [3973]
Pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives 1a-c were prepared from 4-(N-methyl-N-phenylamino)2- methylsulfanylpyrazolo[1,5-a]-1,3,5-triazine 2. Their cytotoxic activity, inhibition of tubulin polymerization, and cell cycle effects were evaluated. Compounds 1a and 1c are potent tubulin inhibitors and displayed specific antiproliferative activity in colorectal cancer cell lines at micromolar concentrations. (C) 2009 Elsevier Ltd. All rights reserved.
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