Taking the pulse of bioprocesses: at-line and in-line monitoring of mammalian cell cultures

Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

(2020) Taehong Kwon et al.   ANALYTICAL CHEMISTRY

A Reliable Automated Sampling System for On-Line and Real-Time Monitoring of CHO Cultures

(2020) Alexandra Hofer et al.   Processes

Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review

(2020) Dhanuka P. Wasalathanthri et al.   BIOTECHNOLOGY AND BIOENGINEERING

Simultaneous Monitoring and Comparison of Multiple Product Quality Attributes for Cell Culture Processes at Different Scales Using a LC/MS/MS Based Multi-Attribute Method

(2020) Yang Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies

(2020) Murali K. Maruthamuthu et al.   TRENDS IN BIOTECHNOLOGY

Real-Time Nanoplasmonic Sensor for IgG Monitoring in Bioproduction

(2020) Thuy Tran et al.   Processes

Control of IgG glycosylation by in situ and real-time estimation of specific growth rate of CHO cells cultured in bioreactor

(2019) Meng-Yao Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

Real-time monitoring and control of CHO cell apoptosis by in situ multifrequency scanning dielectric spectroscopy

(2019) Fuduo Ma et al.   PROCESS BIOCHEMISTRY

A Novel LED-Based 2D-Fluorescence Spectroscopy System for In-line Monitoring of Chinese Hamster Ovary Cell Cultivations - Part I

(2019) Alexander Graf et al.   ENGINEERING IN LIFE SCIENCES

A novel LED-based 2D-fluorescence spectroscopy system for in-line bioprocess monitoring of Chinese hamster ovary cell cultivations-Part II

(2019) Jens Claßen et al.   ENGINEERING IN LIFE SCIENCES

Toward biotherapeutic product real-time quality monitoring

(2019) André Guerra et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Case study: The characterization and implementation of dielectric spectroscopy (biocapacitance) for process control in a commercial GMP CHO manufacturing process

(2019) Brandon Moore et al.   BIOTECHNOLOGY PROGRESS

On-line glucose monitoring by near infrared spectroscopy during the scale up steps of mammalian cell cultivation process development

(2019) Bence Kozma et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

(2019) S. Metze et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Applications of off-gas mass spectrometry in fed-batch mammalian cell culture

(2019) Hai-Yuan Goh et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

A novel microchip‐based imaged CIEF‐MS system for comprehensive characterization and identification of biopharmaceutical charge variants

(2019) Scott Mack et al.   ELECTROPHORESIS

Support Vector and Locally Weighted regressions to monitor monoclonal antibody glycosylation during CHO cell culture processes, an enhanced alternative to Partial Least Squares regression

(2019) Daniel Arturo Zavala-Ortiz et al.   BIOCHEMICAL ENGINEERING JOURNAL

Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

(2019) Nagesh K. Tripathi et al.   Frontiers in Bioengineering and Biotechnology

Parallel comparison of in situ Raman and NIR spectroscopies to simultaneously measure multiple variables toward real-time monitoring of CHO cell bioreactor cultures

(2018) Mengyao Li et al.   BIOCHEMICAL ENGINEERING JOURNAL

A deep learning based data driven soft sensor for bioprocesses

(2018) Vineet Gopakumar et al.   BIOCHEMICAL ENGINEERING JOURNAL

On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements

(2018) Stephen Goldrick et al.   Biotechnology Journal

On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements

(2018) Stephen Goldrick et al.   Biotechnology Journal

Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

(2017) Wolfgang Sommeregger et al.   Biotechnology Journal

Impact of apoptosis on the on-line measured dielectric properties of CHO cells

(2015) Dénes Zalai et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Advances in process monitoring tools for cell culture bioprocesses

(2015) Liang Zhao et al.   ENGINEERING IN LIFE SCIENCES

QbD/PAT for bioprocessing: moving from theory to implementation

(2014) Anurag S Rathore   Current Opinion in Chemical Engineering

Performance monitoring of a mammalian cell based bioprocess using Raman spectroscopy

(2013) Boyan Li et al.   ANALYTICA CHIMICA ACTA

A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach

(2013) Silvia Winckler et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

The changing dielectric properties of CHO cells can be used to determine early apoptotic events in a bioprocess

(2013) Katrin Braasch et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: Prediction of multiple cultivation variables

(2013) Matthieu Clavaud et al.   TALANTA

Process control in cell culture technology using dielectric spectroscopy

(2011) C. Justice et al.   BIOTECHNOLOGY ADVANCES

Estimating cell specific oxygen uptake and carbon dioxide production rates for mammalian cells in perfusion culture

(2011) Chetan T. Goudar et al.   BIOTECHNOLOGY PROGRESS

At-line NIR spectroscopy as effective PAT monitoring technique in Mab cultivations during process development and manufacturing

(2011) Christian Hakemeyer et al.   TALANTA

Advances in on-line monitoring and control of mammalian cell cultures: Supporting the PAT initiative

(2009) A.P. Teixeira et al.   BIOTECHNOLOGY ADVANCES