Case study: The characterization and implementation of dielectric spectroscopy (biocapacitance) for process control in a commercial GMP CHO manufacturing process

Manipulation of the sodium-potassium ratio as a lever for controlling cell growth and improving cell specific productivity in perfusion CHO cell cultures

(2018) Samantha B. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Monitoring mAb cultivations with in-situ raman spectroscopy: The influence of spectral selectivity on calibration models and industrial use as reliable PAT tool

(2018) Rafael M. Santos et al.   BIOTECHNOLOGY PROGRESS

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identifying the differences in mechanisms of mycophenolic acid controlling fucose content of glycoproteins expressed in different CHO cell lines

(2016) An Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

(2015) An Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Universal Capacitance Model for Real-Time Biomass in Cell Culture

(2015) Viktor Konakovsky et al.   SENSORS

Increased CHO cell fed-batch monoclonal antibody production using the autophagy inhibitor 3-MA or gradually increasing osmolality

(2014) S. Soroush Nasseri et al.   BIOCHEMICAL ENGINEERING JOURNAL

Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures

(2014) Cristina Boero et al.   BIOSENSORS & BIOELECTRONICS

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Addition of Valproic Acid to CHO Cell Fed-Batch Cultures Improves Monoclonal Antibody Titers

(2014) William C. Yang et al.   MOLECULAR BIOTECHNOLOGY

Application of an Online-Biomass Sensor in an Optical Multisensory Platform Prototype for Growth Monitoring of Biotechnical Relevant Microorganism and Cell Lines in Single-Use Shake Flasks

(2014) Christian Ude et al.   SENSORS

Application of dielectric spectroscopy for monitoring high cell density in monoclonal antibody producing CHO cell cultivations

(2013) László Párta et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Investigation of metabolic variability observed in extended fed batch cell culture

(2013) Alan Gilbert et al.   BIOTECHNOLOGY PROGRESS

A novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development

(2013) Brandon J. Downey et al.   BIOTECHNOLOGY PROGRESS

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Controlling glycation of recombinant antibody in fed-batch cell cultures

(2011) Inn H. Yuk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Predicting cell-specific productivity from CHO gene expression

(2010) Colin Clarke et al.   JOURNAL OF BIOTECHNOLOGY

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Biomass measurement online: the performance of in situ measurements and software sensors

(2008) Kristiina Kiviharju et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Monoclonal Antibody Therapy for B-Cell Non-Hodgkin's Lymphoma

(2008) Bruce D. Cheson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study

(2005) Marie M. Zhu et al.   BIOTECHNOLOGY PROGRESS