Overview of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1): Functions, regulation, and structural insights of inhibitors

Design and development of novel inhibitors of aldo-ketoreductase 1C1 as potential lead molecules in treatment of breast cancer

(2021) Priyanka Verma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent manner

(2021) Lin-lin Chang et al.   ACTA PHARMACOLOGICA SINICA

Pro‐inflammatory signals induce 20α‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal

(2021) Lubna Nadeem et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Upregulation of AKR1C1 in mesenchymal stromal cells promotes the survival of acute myeloid leukaemia cells

(2020) Yajing Jiang et al.   BRITISH JOURNAL OF HAEMATOLOGY

Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells

(2020) Chen Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overview of AKR1C3: Inhibitor Achievements and Disease Insights

(2020) Yang Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema

(2020) Sandro Michelini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis

(2020) Natascia Marino et al.   npj Breast Cancer

Transcript Levels of Aldo-Keto Reductase Family 1 Subfamily C (AKR1C) Are Increased in Prostate Tissue of Patients with Type 2 Diabetes

(2020) Andras Franko et al.   Journal of Personalized Medicine

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

(2020) Corrin A. Wohlhieter et al.   Cell Reports

Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma

(2019) Liang Wang et al.   OncoTargets and Therapy

Immunohistochemical predictive markers of response to conservative treatment of endometrial hyperplasia and early endometrial cancer: A systematic review

(2019) Antonio Travaglino et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Targeted Delivery of Zoledronate to Tumor-Associated Macrophages for Cancer Immunotherapy

(2019) Xinlong Zang et al.   MOLECULAR PHARMACEUTICS

AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway

(2019) Wei-Min Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses

(2019) Jizhen Huang et al.   MEDICINE

Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism

(2019) Chenming Zeng et al.   Frontiers in Physiology

Correlation of NRF2 and progesterone receptor and its effects on ovarian cancer biology

(2019) Bastian Czogalla et al.   Cancer Management and Research

Circular RNAs in drug resistant tumors

(2019) Xin Hua et al.   BIOMEDICINE & PHARMACOTHERAPY

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

(2019) Mara Gagliardi et al.   Cell Death & Disease

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

(2019) Yulin Shi et al.   Nature Communications

Role of human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C3) in the extrahepatic metabolism of the steroidal aromatase inactivator Formestane

(2019) Runlan Wan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

AKR1C enzymes sustain therapy resistance in paediatric T-ALL

(2018) Roberta Bortolozzi et al.   BRITISH JOURNAL OF CANCER

Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung

(2018) Joseph H Ashmore et al.   CARCINOGENESIS

Effect of particulate matter 2.5 on gene expression profile and cell signaling in JEG-3 human placenta cells

(2018) Woong Kim et al.   ENVIRONMENTAL TOXICOLOGY

Regulation of prostate cancer by hormone-responsive G protein-coupled receptors

(2018) Wei Wang et al.   PHARMACOLOGY & THERAPEUTICS

Testosterone metabolites inhibit proliferation of castration- and therapy-resistant prostate cancer

(2018) Felix Bremmer et al.   Oncotarget

AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer

(2018) Hong ZHU et al.   Theranostics

The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy

(2018) Eduardo Spinedi et al.   International Journal of Endocrinology

Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone

(2018) Jessica R. Murray et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis

(2018) Christian U. Huebbers et al.   INTERNATIONAL JOURNAL OF CANCER

Le glaucome primitif à angle ouvert

(2018) S. Bertaud et al.   REVUE DE MEDECINE INTERNE

Pharmacogenetics of aldo-keto reductase 1C (AKR1C) enzymes

(2017) Osama Y. Alshogran   Expert Opinion on Drug Metabolism & Toxicology

Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily

(2017) Akira Hara et al.   JOURNAL OF BIOCHEMISTRY

Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin

(2017) Xia Sheng et al.   MOLECULAR CANCER RESEARCH

Loss of luteotropic prostaglandin E plays an important role in the regulation of luteolysis in women

(2017) Junko Nio-Kobayashi et al.   MOLECULAR HUMAN REPRODUCTION

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity

(2017) Masashi Shiiba et al.   ONCOLOGY REPORTS

Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses

(2017) Trillitye Paullin et al.   PLoS One

Progesterone suppresses the invasion and migration of breast cancer cells irrespective of their progesterone receptor status - a short report

(2017) Mukul Godbole et al.   CELLULAR ONCOLOGY

Aldo–Keto Reductase AKR1C1–AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy

(2017) Chen-Ming Zeng et al.   Frontiers in Pharmacology

Endocrinology of human parturition

(2016) Silvia Vannuccini et al.   ANNALES D ENDOCRINOLOGIE

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway

(2016) Yiying Wang et al.   Oncotarget

The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death

(2016) Wei Li et al.   Oncotarget

Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells

(2016) Ryuji Matsumoto et al.   Scientific Reports

Hormone-related pathways and risk of breast cancer subtypes in African American women

(2015) Stephen A. Haddad et al.   BREAST CANCER RESEARCH AND TREATMENT

In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis

(2015) Yining Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Ruthenium complexes as inhibitors of the aldo–keto reductases AKR1C1–1C3

(2015) Katja Traven et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The aldo-keto reductases (AKRs): Overview

(2015) Trevor M. Penning   CHEMICO-BIOLOGICAL INTERACTIONS

Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer

(2015) Antonia Wenners et al.   International Journal of Clinical Oncology

Promiscuity and diversity in 3-ketosteroid reductases

(2015) Trevor M. Penning et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Updated survey of the steroid-converting enzymes in human adipose tissues

(2015) André Tchernof et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells

(2015) Chunling Liu et al.   Oncotarget

Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

(2015) Huiyoung Yun et al.   Oncotarget

Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

(2015) Benjamin Le Calvé et al.   NEOPLASIA

Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells

(2014) Toshiyuki Matsunaga et al.   ANTI-CANCER DRUGS

Determination of Sulfotransferase Forms Involved in the Metabolic Activation of the Genotoxicant 1-Hydroxymethylpyrene Using Bacterially Expressed Enzymes and Genetically Modified Mouse Models

(2014) Carolin Bendadani et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons

(2014) Trevor M. Penning   CHEMICAL RESEARCH IN TOXICOLOGY

The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man

(2014) Petra Malátková et al.   CHEMICO-BIOLOGICAL INTERACTIONS

GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THEAKR1C1GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY?

(2014) Carina Quast et al.   DEPRESSION AND ANXIETY

A Prolyl-Hydroxylase Inhibitor, Ethyl-3,4-Dihydroxybenzoate, Induces Cell Autophagy and Apoptosis in Esophageal Squamous Cell Carcinoma Cells via Up-Regulation of BNIP3 and N-myc Downstream-Regulated Gene-1

(2014) Bo Han et al.   PLoS One

In vitrometabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism

(2014) Christian Atsriku et al.   XENOBIOTICA

Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification

(2013) Chih-Cheng Chen et al.   BIOCHEMICAL PHARMACOLOGY

Deeper Insight into the Reducing Biotransformation of Bupropion in the Human Liver

(2013) Lucie Skarydova et al.   Drug Metabolism and Pharmacokinetics

Hepatitis B Virus X Protein Up-Regulates AKR1C1 Expression Through Nuclear Factor-Y in Human Hepatocarcinoma Cells

(2013) Kai Li et al.   Hepatitis Monthly

AKR1C3 as a target in castrate resistant prostate cancer

(2013) Adegoke O. Adeniji et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Deconvoluting complex tissues for expression quantitative trait locus-based analyses

(2013) J.-H. Seo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism

(2013) Tea Lanišnik Rižner et al.   STEROIDS

Methyljasmonate displaysin vitroandin vivoactivity against multiple myeloma cells

(2012) Steffen Klippel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk

(2012) Erika M. Kwon et al.   Cancer Epidemiology

Genetic Polymorphisms in Oxidative Stress Pathway Genes and Modification of BMI and Risk of Non-Hodgkin Lymphoma

(2012) C. Kim et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant

(2012) Toshiyuki Matsunaga et al.   CELL AND TISSUE RESEARCH

Progestin effects on expression of AKR1C1–AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line

(2012) Nataša Beranič et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pathophysiological roles of aldo–keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers

(2012) Toshiyuki Matsunaga et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Transactivation activity of human papillomavirus type 16 E6*I on aldo-keto reductase genes enhances chemoresistance in cervical cancer cells

(2012) P. Wanichwatanadecha et al.   JOURNAL OF GENERAL VIROLOGY

Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library

(2012) Petra Brožič et al.   JOURNAL OF MEDICINAL CHEMISTRY

The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients

(2012) Lihua Wang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

(2012) Nataša Beranič et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Carcinogenicity of diesel-engine and gasoline-engine exhausts and some nitroarenes

(2012) Lamia Benbrahim-Tallaa et al.   LANCET ONCOLOGY

Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetonein vitro

(2012) Lucie Skarydova et al.   XENOBIOTICA

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases

(2012) Tea Lanišnik Rižner   Frontiers in Pharmacology

Retinaldehyde is a substrate for human aldo–keto reductases of the 1C subfamily

(2011) F. Xavier Ruiz et al.   BIOCHEMICAL JOURNAL

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1–AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

(2011) Yi Jin et al.   BIOCHEMICAL JOURNAL

Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis

(2011) Ossama El-Kabbani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Impaired neurosteroid synthesis in multiple sclerosis

(2011) Farshid Noorbakhsh et al.   BRAIN

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

(2011) Abena S. Agyeman et al.   BREAST CANCER RESEARCH AND TREATMENT

Activities of aldo-keto reductase 1 enzymes on two inhaled corticosteroids: Implications for the pharmacological effects of inhaled corticosteroids

(2011) Yi Jin   CHEMICO-BIOLOGICAL INTERACTIONS

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

(2011) N. Hevir et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibitors of Aldo-Keto Reductases AKR1C1-AKR1C4

(2011) P. Brozic et al.   CURRENT MEDICINAL CHEMISTRY

Formation of a 3,4-diol-1,2-epoxide metabolite of benz[a]anthracene with cytotoxicity and genotoxicity in a human in vitro hepatocyte culture system

(2011) Mi-Kyung Song et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Human hydroxysteroid dehydrogenases and pre-receptor regulation: Insights into inhibitor design and evaluation

(2011) Trevor M. Penning   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo–keto reductase superfamily

(2011) Yi Jin et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

(2011) Adam Lister et al.   Molecular Cancer

Modeling Single Nucleotide Polymorphisms in the Human AKR1C1 and AKR1C2 Genes: Implications for Functional and Genotyping Analyses

(2011) Jonathan W. Arthur et al.   PLoS One

Factorizing the role of a critical leucine residue in the binding of substrate to human 20α-hydroxysteroid dehydrogenase (AKR1C1): Molecular modeling and kinetic studies of the Leu308Val mutant enzyme

(2010) Urmi Dhagat et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3

(2010) N. Beranič et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Upregulated Expression of hITF in Crohn’s Disease and Screening of hITF Interactant by a Yeast Two-Hybrid System

(2010) Huaxiu Shi et al.   DIGESTIVE DISEASES AND SCIENCES

Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors

(2010) Ossama El-Kabbani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

(2010) O. S. Bains et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1)

(2010) Ossama El-Kabbani et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): Overview and structural insights

(2010) Michael C. Byrns et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast

(2010) M Bauer et al.   ONCOGENE

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

(2010) Karen E. Knudsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of CYP27A1 in progesterone metabolism in vitro and in vivo

(2009) Geneviève Escher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

(2009) Trevor M. Penning et al.   Annals of the New York Academy of Sciences

New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3

(2009) Bogdan Štefane et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival

(2009) Yarí E. Marín et al.   EXPERIMENTAL DERMATOLOGY

Single nucleotide differences (SNDs) in the dbSNP database may lead to errors in genotyping and haplotyping studies

(2009) Lucia Musumeci et al.   HUMAN MUTATION

Human Cytosolic Hydroxysteroid Dehydrogenases of the Aldo-ketoreductase Superfamily Catalyze Reduction of Conjugated Steroids

(2009) Yi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Guided Design, Synthesis, and Evaluation of Salicylic Acid-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human 20α-Hydroxysteroid Dehydrogenase (AKR1C1)

(2009) Ossama El-Kabbani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer

(2009) Mirjam C Boelens et al.   JOURNAL OF PATHOLOGY

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

(2009) Michael C. Byrns et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Temporal–spatial analysis of U.S.–Mexico border environmental fine and coarse PM air sample extract activity in human bronchial epithelial cells

(2009) Fredine T. Lauer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AKR1C1andSRD5A1Messenger RNA Expression at Term in the Human Myometrium and Chorioamniotic Membranes

(2008) Richard Lee et al.   AMERICAN JOURNAL OF PERINATOLOGY

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20α-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity

(2008) Vincenzo Carbone et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors

(2008) Felix Glahn et al.   ARCHIVES OF TOXICOLOGY

Comparisons of (±)-Benzo[a]pyrene-trans-7,8-Dihydrodiol Activation by Human Cytochrome P450 and Aldo−Keto Reductase Enzymes: Effect of Redox State and Expression Levels

(2008) Amy M. Quinn et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1

(2008) P. Brožič et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Progesterone is Extensively Metabolized in Osteoblasts: Implications for Progesterone Action on Bone

(2008) M. Quinkler et al.   HORMONE AND METABOLIC RESEARCH

Estrogen and Progesterone Metabolism in the Cervix during Pregnancy and Parturition

(2008) Stefan Andersson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selectivity Determinants of Inhibitor Binding to Human 20α-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid†

(2008) Urmi Dhagat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epidemiology and causes of preterm birth

(2008) Robert L Goldenberg et al.   LANCET

Androgen metabolism in adipose tissue: Recent advances

(2008) Karine Blouin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Discovery of new inhibitors of aldo-keto reductase 1C1 by structure-based virtual screening

(2008) Petra Brožič et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Disturbed estrogen and progesterone action in ovarian endometriosis

(2008) Tina Šmuc et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer

(2008) Tina Šmuc et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Monolayer and Spheroid Culture of Human Liver Hepatocellular Carcinoma Cell Line Cells Demonstrate Distinct Global Gene Expression Patterns and Functional Phenotypes

(2008) Tammy T. Chang et al.   TISSUE ENGINEERING PART A

Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: Role in the cell cycle and apoptosis

(2007) Elisabet Selga et al.   BIOCHEMICAL PHARMACOLOGY