Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

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SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

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LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma

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Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death

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AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway

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An Lkb1-Sik axis suppresses lung tumor growth and controls differentiation

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Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer

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Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

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NRF2 and the Hallmarks of Cancer

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STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma

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AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer

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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

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Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies

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Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism

(2016) R. Ariel Igal   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

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Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)

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Somatic STK11 and Concomitant STK11/KRAS Mutational Frequency in Stage IV Lung Adenocarcinoma Adrenal Metastases

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A Central Role for mTOR in Lipid Homeostasis

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Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

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Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase-1 Inhibitors as Novel Therapeutics for Human Disease

(2013) Zaihui Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of aldo-keto reductases as NRF2-target marker genes in human cells

(2013) Kyeong-Ah Jung et al.   TOXICOLOGY LETTERS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

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Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer

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Lung Cancer

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