Aldo–Keto Reductase AKR1C1–AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy
出版年份 2017 全文链接
标题
Aldo–Keto Reductase AKR1C1–AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-03-14
DOI
10.3389/fphar.2017.00119
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Human 3 -hydroxysteroid dehydrogenase type 3: structural clues of 5 -DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth
- (2016) B. Zhang et al. BIOCHEMICAL JOURNAL
- Pyrithione-based ruthenium complexes as inhibitors of aldo–keto reductase 1C enzymes and anticancer agents
- (2016) Jakob Kljun et al. DALTON TRANSACTIONS
- Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis
- (2016) Malin Hagberg Thulin et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation
- (2016) Shao-Qian Sun et al. Oncotarget
- Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway
- (2016) Yiying Wang et al. Oncotarget
- Classical and Non-Classical Roles for Pre-Receptor Control of DHT Metabolism in Prostate Cancer Progression
- (2016) Ailin Zhang et al. Hormones & Cancer
- Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes
- (2016) Douglas A. Gibson et al. Scientific Reports
- Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases
- (2015) Jakub Hofman et al. BIOCHEMICAL PHARMACOLOGY
- Aldo-keto reductase 1C3 (AKR1C3) is associated with the doxorubicin resistance in human breast cancer via PTEN Loss
- (2015) Ting Zhong et al. BIOMEDICINE & PHARMACOTHERAPY
- In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis
- (2015) Yining Zhao et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)
- (2015) Tianzhu Zang et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines
- (2015) Maša Sinreih et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Ruthenium complexes as inhibitors of the aldo–keto reductases AKR1C1–1C3
- (2015) Katja Traven et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2α biosynthesis and action in ovarian endometriosis tissue and in model cell lines
- (2015) Maša Sinreih et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer
- (2015) Antonia Wenners et al. International Journal of Clinical Oncology
- The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells
- (2015) Lingling Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer
- (2015) Tomomi Yoda et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer
- (2015) Cong Li et al. ONCOLOGY RESEARCH
- Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells
- (2014) Toshiyuki Matsunaga et al. ANTI-CANCER DRUGS
- Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)
- (2014) Jack U. Flanagan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression
- (2014) Yuantong Tian et al. Diagnostic Pathology
- Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study
- (2014) Yohann Loriot et al. INVESTIGATIONAL NEW DRUGS
- Elevated Expression of AKR1C3 Increases Resistance of Cancer Cells to Ionizing Radiation via Modulation of Oxidative Stress
- (2014) Wei Xiong et al. PLoS One
- Anthracycline resistance mediated by reductive metabolism in cancer cells: The role of aldo-keto reductase 1C3
- (2014) Jakub Hofman et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer
- (2014) Yarong Diana Yin et al. Frontiers in Oncology
- Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium
- (2013) Scott H Garrett et al. BMC Medical Genomics
- The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity
- (2013) Jianfei Qi et al. CANCER CELL
- Aldo-keto reductase 1C3 may be a new radioresistance marker in non-small-cell lung cancer
- (2013) L Xie et al. CANCER GENE THERAPY
- Panax ginseng polysaccharide induces apoptosis by targeting Twist/AKR1C2/NF-1 pathway in human gastric cancer
- (2013) Cong Li et al. CARBOHYDRATE POLYMERS
- Steroidogenic Enzyme AKR1C3 Is a Novel Androgen Receptor-Selective Coactivator that Promotes Prostate Cancer Growth
- (2013) M. Yepuru et al. CLINICAL CANCER RESEARCH
- Synthesis and structure–activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3
- (2013) Daniel M. Heinrich et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Clinical implications of aldo-keto reductase family 1 member C3 and its relationship with lipocalin 2 in cancer of the uterine cervix
- (2013) Chih-Hsien Wu et al. GYNECOLOGIC ONCOLOGY
- Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer
- (2013) Andy J. Liedtke et al. JOURNAL OF MEDICINAL CHEMISTRY
- Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism
- (2013) Tea Lanišnik Rižner et al. STEROIDS
- Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization
- (2012) Allan D Heibein et al. BMC CANCER
- Methylation of the KEAP1 gene promoter region in human colorectal cancer
- (2012) Naoyuki Hanada et al. BMC CANCER
- Pathophysiological roles of aldo–keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers
- (2012) Toshiyuki Matsunaga et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Polymorphisms in AKR1C4 and HSD3B2 and differences in serum DHEAS and progesterone are associated with paranoid ideation during mania or hypomania in bipolar disorder
- (2012) Anette G.M. Johansson et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-β-Hydroxysteroid Dehydrogenase AKR1C3
- (2012) Stephen M. F. Jamieson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adaptation or selection—mechanisms of castration-resistant prostate cancer
- (2012) Yang Zong et al. Nature Reviews Urology
- Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)
- (2011) Adegoke O. Adeniji et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- PTHrP stimulates prostate cancer cell growth and upregulates aldo–keto reductase 1C3
- (2011) Tracy M. Downs et al. CANCER LETTERS
- Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer-derived stromal cells
- (2011) Xunxian Liu et al. CARCINOGENESIS
- Potential Prostate Cancer Drug Target: Bioactivation of Androstanediol by Conversion to Dihydrotestosterone: Figure 1.
- (2011) James L. Mohler et al. CLINICAL CANCER RESEARCH
- AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder
- (2011) Anette G.M. Johansson et al. JOURNAL OF AFFECTIVE DISORDERS
- Increased androgen receptor transcription: a cause of castration-resistant prostate cancer and a possible therapeutic target
- (2011) Masaki Shiota et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- New and emerging agents for the treatment of castration-resistant prostate cancer
- (2011) Celestia S. Higano et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- Evidence of Limited Contributions for Intratumoral Steroidogenesis in Prostate Cancer
- (2010) J. Hofland et al. CANCER RESEARCH
- Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3
- (2010) N. Beranič et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors
- (2010) Ossama El-Kabbani et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3
- (2009) Bogdan Štefane et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase
- (2008) Vincenzo Carbone et al. BIOORGANIC & MEDICINAL CHEMISTRY
- AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids
- (2008) Lucie Škarydová et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1
- (2008) P. Brožič et al. CHEMICO-BIOLOGICAL INTERACTIONS
- The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification
- (2008) Oleg A. Barski et al. DRUG METABOLISM REVIEWS
- Steroidal lactones as inhibitors of 17β-hydroxysteroid dehydrogenase type 5: Chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities
- (2008) Patrick Bydal et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Inactivation of the anticancer drugs doxorubicin and oracin by aldo–keto reductase (AKR) 1C3
- (2008) Romana Novotna et al. TOXICOLOGY LETTERS
- Mechanisms mediating androgen receptor reactivation after castration
- (2008) Xin Yuan et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies
- (2007) Michael C. Byrns et al. BIOCHEMICAL PHARMACOLOGY
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