Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells

(2018) Paola Giglio et al.   OncoImmunology

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)

(2017) Jacob Schachter et al.   LANCET

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis

(2016) Trevor M. Penning   CHEMICAL RESEARCH IN TOXICOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

The aldo-keto reductases (AKRs): Overview

(2015) Trevor M. Penning   CHEMICO-BIOLOGICAL INTERACTIONS

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

(2015) Rebecca R. Crawford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRAF Inhibition Generates a Host–Tumor Niche that Mediates Therapeutic Escape

(2015) Inna V. Fedorenko et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

(2014) M Corazzari et al.   CELL DEATH AND DIFFERENTIATION

CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade

(2014) I. N. Mungrue et al.   JOURNAL OF IMMUNOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

A Somatic Mutation of the KEAP1 Gene in Malignant Melanoma Is Involved in Aberrant NRF2 Activation and an Increase in Intrinsic Drug Resistance

(2013) Shinpei Miura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Why is autophagy important for melanoma? Molecular mechanisms and therapeutic implications

(2013) Marco Corazzari et al.   SEMINARS IN CANCER BIOLOGY

Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease

(2013) J Xu et al.   Cell Death & Disease

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition

(2012) Kavitha Gowrishankar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic alterations of PTEN in human melanoma

(2011) Almass-Houd Aguissa-Touré et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oncogenic B-RAF Signaling in Melanoma Impairs the Therapeutic Advantage of Autophagy Inhibition

(2011) J. L. Armstrong et al.   CLINICAL CANCER RESEARCH

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

(2011) X.-H. Ma et al.   CLINICAL CANCER RESEARCH

BRAFV600E: Implications for Carcinogenesis and Molecular Therapy

(2011) E. R. Cantwell-Dorris et al.   MOLECULAR CANCER THERAPEUTICS

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting BRAF for patients with melanoma

(2010) H-T Arkenau et al.   BRITISH JOURNAL OF CANCER

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRAF Signaling and Targeted Therapies in Melanoma

(2009) Nathalie Dhomen et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Cell line cross-contamination initiative: An interactive reference database of STR profiles covering common cancer cell lines

(2009) Wilhelm G. Dirks et al.   INTERNATIONAL JOURNAL OF CANCER

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in cutaneous malignant melanoma

(2009) Rossitza Lazova et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Two types of human malignant melanoma cell lines revealed by expression patterns of mitochondrial and survival-apoptosis genes: implications for malignant melanoma therapy

(2009) D. M. Su et al.   MOLECULAR CANCER THERAPEUTICS

The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification

(2008) Oleg A. Barski et al.   DRUG METABOLISM REVIEWS

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY