SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Severe acute kidney injury in critically ill COVID-19 patients

(2021) Gaston J. Piñeiro et al.   JOURNAL OF NEPHROLOGY

Experimental Models to Study COVID-19 Effect in Stem Cells

(2021) Rishi Man Chugh et al.   Cells

Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro

(2021) Finny Varghese et al.   Viruses-Basel

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

(2021) Nicholas Murgolo et al.   PLoS Pathogens

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

(2021) Toni M. Delorey et al.   NATURE

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

(2021) Yoshiharu Muto et al.   Nature Communications

Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection

(2021) Bo Diao et al.   Nature Communications

Kidney Outcomes in Long COVID

(2021) Benjamin Bowe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions

(2021) Dorit Omer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single‐cell transcriptomics reveals immune response of intestinal cell types to viral infection

(2021) Sergio Triana et al.   Molecular Systems Biology

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

(2020) Pierre Bost et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Acute on chronic liver failure from novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

(2020) He Qiu et al.   LIVER INTERNATIONAL

Targeted Perturb-seq enables genome-scale genetic screens in single cells

(2020) Daniel Schraivogel et al.   NATURE METHODS

Multiorgan and Renal Tropism of SARS-CoV-2

(2020) Victor G. Puelles et al.   NEW ENGLAND JOURNAL OF MEDICINE

SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics

(2020) Simon Cabello-Aguilar et al.   NUCLEIC ACIDS RESEARCH

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Crowdsourcing drug discovery for pandemics

(2020) John Chodera et al.   Nature Chemistry

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

(2020) Yuhei Kirita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration

(2020) Alessandra Tammaro et al.   Frontiers in Immunology

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

(2020) Fadi Jacob et al.   Cell Stem Cell

SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

(2020) Laura Pellegrini et al.   Cell Stem Cell

Hunting coronavirus by transmission electron microscopy – a guide to SARS‐CoV‐2‐associated ultrastructural pathology in COVID‐19 tissues

(2020) Helmut Hopfer et al.   HISTOPATHOLOGY

SARS-CoV-2 renal tropism associates with acute kidney injury

(2020) Fabian Braun et al.   LANCET

WNT–β-catenin signalling — a versatile player in kidney injury and repair

(2020) Stefan J. Schunk et al.   Nature Reviews Nephrology

The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV

(2020) Mihkel Örd et al.   Scientific Reports

Acute Kidney Injury in a National Cohort of Hospitalized US Veterans with COVID-19

(2020) Benjamin Bowe et al.   Clinical Journal of the American Society of Nephrology

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project

(2020) Tarek M. El-Achkar et al.   PHYSIOLOGICAL GENOMICS

Benchmark and integration of resources for the estimation of human transcription factor activities

(2019) Luz Garcia-Alonso et al.   GENOME RESEARCH

Proximal Tubule Translational Profiling during Kidney Fibrosis Reveals Proinflammatory and Long Noncoding RNA Expression Patterns with Sexual Dimorphism

(2019) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription

(2019) Ming Kong et al.   Redox Biology

Interleukin-1βActivates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

(2018) Dario R. Lemos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Advances in predictive in vitro models of drug-induced nephrotoxicity

(2018) Joanne Y.-C. Soo et al.   Nature Reviews Nephrology

Perturbation-response genes reveal signaling footprints in cancer gene expression

(2018) Michael Schubert et al.   Nature Communications

Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis

(2018) Jean Z. Lin et al.   Cell Reports

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

(2018) Sandra Rayego-Mateos et al.   MEDIATORS OF INFLAMMATION

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Evaluation of variability in human kidney organoids

(2018) Belinda Phipson et al.   NATURE METHODS

The Evolving Complexity of the Podocyte Cytoskeleton

(2017) Christoph Schell et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

c-Myc promotes renal fibrosis by inducing integrin αv-mediated transforming growth factor-β signaling

(2017) Yang Shen et al.   KIDNEY INTERNATIONAL

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Origin and fate of the regenerating cells of the kidney

(2016) Jennifer Eymael et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tubular Epithelial NF- B Activity Regulates Ischemic AKI

(2016) L. Marko et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Functional characterization of somatic mutations in cancer using network-based inference of protein activity

(2016) Mariano J Alvarez et al.   NATURE GENETICS

Generation of kidney organoids from human pluripotent stem cells

(2016) Minoru Takasato et al.   Nature Protocols

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study

(2015) Eric A. J. Hoste et al.   INTENSIVE CARE MEDICINE

Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

(2015) Takashi Muramatsu   JOURNAL OF BIOCHEMISTRY

SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β

(2015) Gonzalo Córdova et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

(2015) Rafael Kramann et al.   JOURNAL OF CLINICAL INVESTIGATION

Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk

(2015) O. H. Maarouf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Cellular and molecular mechanisms in kidney fibrosis

(2014) Jeremy S. Duffield   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(2014) Florian Grahammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Renal epithelial injury and fibrosis

(2013) Brigitte Kaissling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease

(2013) Rafael Kramann et al.   JOURNAL OF PATHOLOGY

A Bioinformatics Approach Identifies Signal Transducer and Activator of Transcription-3 and Checkpoint Kinase 1 as Upstream Regulators of Kidney Injury Molecule-1 after Kidney Injury

(2013) A. K. Ajay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication

(2013) Dong Zhou et al.   Scientific Reports

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Induction of heat shock protein 70 inhibits ischemic renal injury

(2011) Zhiyong Wang et al.   KIDNEY INTERNATIONAL

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION