Bispecific antibody CD73xEpCAM selectively inhibits the adenosine-mediated immunosuppressive activity of carcinoma-derived extracellular vesicles

Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling

(2020) Nils Ludwig et al.   ANGIOGENESIS

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Bispecific antibody approach for improved melanoma-selective PD-L1 immune checkpoint blockade.

(2019) Iris Koopmans et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Metabolome of Exosomes: Focus on Vesicles Released by Cancer Cells and Present in Human Body Fluids

(2019) Aneta Zebrowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Generation and Function of Non-cell-bound CD73 in Inflammation

(2019) Enja Schneider et al.   Frontiers in Immunology

EpCAM associates with integrin and regulates cell adhesion in cancer cells

(2019) Jie Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

CD20-selective inhibition of CD47-SIRPα “don't eat me” signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab

(2017) Peter E. van Bommel et al.   OncoImmunology

CD73–adenosine: a next-generation target in immuno-oncology

(2016) David Allard et al.   Immunotherapy

Targeting CD73 in the tumor microenvironment with MEDI9447

(2016) Carl M. Hay et al.   OncoImmunology

Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment

(2016) Luca Antonioli et al.   OncoImmunology

Insights into the molecular basis of a bispecific antibody's target selectivity

(2015) Yariv Mazor et al.   mAbs

Immunosuppression of breast cancer cells mediated by transforming growth factor-β in exosomes from cancer cells

(2015) LEI RONG et al.   Oncology Letters

Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

(2014) P. J. Schuler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Proteome–Metabolome Profiling of Ovarian Cancer Ascites Reveals Novel Components Involved in Intercellular Communication

(2014) Victoria O. Shender et al.   MOLECULAR & CELLULAR PROTEOMICS

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

(2014) J P Webber et al.   ONCOGENE

Detection of Tumor Cell-Specific mRNA and Protein in Exosome-Like Microvesicles from Blood and Saliva

(2014) Jieping Yang et al.   PLoS One

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

(2013) Omid Vafa et al.   METHODS

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

(2011) Jianying Dong et al.   mAbs

Proteomic and immunologic analyses of brain tumor exosomes

(2008) Michael W. Graner et al.   FASEB JOURNAL