Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4‐Thiazolidinedione‐Based Molecules as New Dual mPGES‐1/5‐LO Inhibitors

(2020) Gianluigi Lauro et al.   ChemMedChem

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

(2020) Nathaniel C. Gilbert et al.   Nature Chemical Biology

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution

(2020) Paul M. Jordan et al.   Cell Reports

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

(2019) Markus Werner et al.   FASEB JOURNAL

Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy

(2019) Jana Gerstmeier et al.   BIOCHEMICAL PHARMACOLOGY

Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis

(2019) Erik Romp et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukotriene biosynthetic enzymes as therapeutic targets

(2018) Jesper Z. Haeggström   JOURNAL OF CLINICAL INVESTIGATION

Celastrol attenuates incision-induced inflammation and pain associated with inhibition of the NF-κB signalling pathway via SARM

(2018) Xuhui Chen et al.   LIFE SCIENCES

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

(2018) Shao-Ru Chen et al.   Frontiers in Pharmacology

Celastrol Alleviates Airway Hyperresponsiveness and Inhibits Th17 Responses in Obese Asthmatic Mice

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Molecular modulators of celastrol as the keystones for its diverse pharmacological activities

(2018) Sin Wi Ng et al.   BIOMEDICINE & PHARMACOTHERAPY

A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway

(2017) Wenyu Xin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

(2017) Simona Pace et al.   JOURNAL OF CLINICAL INVESTIGATION

Actions of SPM in regulating host responses in arthritis

(2017) Mauro Perretti et al.   MOLECULAR ASPECTS OF MEDICINE

Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation

(2017) Xianjun Yu et al.   Oncotarget

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes

(2016) Jana Gerstmeier et al.   FASEB JOURNAL

Celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A 2 group IIA, 5-lipoxygenase and cyclooxygenase-2

(2016) Vikram Joshi et al.   PHARMACOLOGICAL RESEARCH

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice

(2015) Zhenyu Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

(2015) Jie Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

(2015) Hu Meng et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Macrophage development and polarization in chronic inflammation

(2015) Madhur P. Motwani et al.   SEMINARS IN IMMUNOLOGY

Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis

(2014) Mohamed E. Shaker et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis

(2014) Antonietta Rossi et al.   PHARMACOLOGICAL RESEARCH

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Effective treatment of rat adjuvant-induced arthritis by celastrol

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Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

UCSF Chimera, MODELLER, and IMP: An integrated modeling system

(2011) Zheng Yang et al.   JOURNAL OF STRUCTURAL BIOLOGY

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(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Therapeutic effect of tripterine on adjuvant arthritis in rats

(2008) Hong Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

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(2008) Ruslan Medzhitov   NATURE

Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids

(2007) Ulf Siemoneit et al.   BIOCHEMICAL PHARMACOLOGY