Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPAIncrease Systemic Inflammation and Cardiovascular DiseaseNovelty and Significance

(2018) Romain A. Colas et al.   CIRCULATION RESEARCH

AT-RvD1 modulates the activation of bronchial epithelial cells induced by lipopolysaccharide and Dermatophagoides pteronyssinus

(2017) Jhony Robison de Oliveira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress

(2017) Bibiana Rius et al.   FASEB JOURNAL

13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis

(2017) Mary E. Walker et al.   FASEB JOURNAL

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

(2017) Jesmond Dalli et al.   IMMUNITY

Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury

(2017) Izhar Livne-Bar et al.   JOURNAL OF CLINICAL INVESTIGATION

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

(2017) Isaac Francos-Quijorna et al.   JOURNAL OF NEUROSCIENCE

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections?

(2017) Jesmond Dalli   MOLECULAR ASPECTS OF MEDICINE

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Protectin D1n-3 DPAand resolvin D5n-3 DPAare effectors of intestinal protection

(2017) Thomas Gobbetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23

(2017) Satoshi Deyama et al.   PSYCHOPHARMACOLOGY

Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway

(2017) Giorgio Mottola et al.   PLoS One

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia

(2016) Jennifer K. Colby et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvin D2 Enhances Postischemic Revascularization While Resolving InflammationClinical Perspective

(2016) Michael J. Zhang et al.   CIRCULATION

Risk of infections using anti-TNF agents in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: a systematic review and meta-analysis

(2016) Silvia Minozzi et al.   Expert Opinion On Drug Safety

Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid

(2016) James F. Markworth et al.   FASEB JOURNAL

Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

(2016) Krishnaraj S. Rathod et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes

(2016) Marcelo O. Freire et al.   JOURNAL OF IMMUNOLOGY

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

(2016) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation

(2016) Romain A. Colas et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32

(2016) Mattia Schmid et al.   JOURNAL OF IMMUNOLOGY

Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins

(2016) Karoline G. Primdahl et al.   JOURNAL OF NATURAL PRODUCTS

Resolvin E1 Inhibits Substance P-Induced Potentiation of TRPV1 in Primary Sensory Neurons

(2016) Youn Yi Jo et al.   MEDIATORS OF INFLAMMATION

New tools to tackle inflammatory arthritis

(2016) Charles A. Dinarello et al.   Nature Reviews Rheumatology

Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents

(2016) Hayato Fukuda et al.   ORGANIC LETTERS

Specialised pro-resolving mediators of inflammation in inflammatory arthritis

(2016) Anne E. Barden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

(2016) Jeremy W. Winkler et al.   Scientific Reports

Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells

(2016) Robin R. Hodges et al.   Scientific Reports

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

(2015) Sarah K. Orr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

(2015) Mario Romano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages

(2015) Magdalena Herová et al.   JOURNAL OF IMMUNOLOGY

Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters

(2015) Kishore Cholkar et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice

(2014) G. Ortiz-Munoz et al.   BLOOD

Total Synthesis of the Anti-inflammatory and Pro-resolving Lipid Mediator MaR1n−3 DPAUtilizing an sp3-sp3Negishi Cross-Coupling Reaction

(2014) Jørn Eivind Tungen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis

(2014) T.E. Van Dyke et al.   JOURNAL OF DENTAL RESEARCH

Total Synthesis of the Lipid Mediator PD1n-3 DPA: Configurational Assignments and Anti-inflammatory and Pro-resolving Actions

(2014) Marius Aursnes et al.   JOURNAL OF NATURAL PRODUCTS

Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats

(2014) Z.-F. Wang et al.   NEUROSCIENCE

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

(2014) Raja-Elie E. Abdulnour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

(2013) Jesmond Dalli et al.   CHEMISTRY & BIOLOGY

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32

(2013) Hye Ja Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3

(2013) Y. Isobe et al.   JOURNAL OF BIOCHEMISTRY

Proresolution Lipid Mediators in Multiple Sclerosis — Differential, Disease Severity-Dependent Synthesis — A Clinical Pilot Trial

(2013) Harald Prüss et al.   PLoS One

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel n-3 Immunoresolvents: Structures and Actions

(2013) Jesmond Dalli et al.   Scientific Reports

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma

(2012) Jun Miyata et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field

(2012) Bengt Samuelsson   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing

(2011) L. V. Norling et al.   JOURNAL OF IMMUNOLOGY

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice

(2010) Tomohiro Yamada et al.   FASEB JOURNAL

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways

(2009) Xavier Rovira et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ATL-1, an analogue of aspirin-triggered lipoxin A4, is a potent inhibitor of several steps in angiogenesis induced by vascular endothelial growth factor

(2008) P F T Cezar-de-Mello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE