Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Benefits of Iron Chelators in the Treatment of Parkinson’s Disease

(2021) Xiaoyan Zeng et al.   NEUROCHEMICAL RESEARCH

Parkinson’s Disease: Alterations in Iron and Redox Biology as a Key to Unlock Therapeutic Strategies

(2021) L. Ma et al.   Redox Biology

Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis

(2021) Li-Mei Song et al.   iScience

Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury

(2021) Zhou Feng et al.   Redox Biology

Ferroptosis: copper-iron connection in cuprizone-induced demyelination

(2021) Samuel David et al.   Neural Regeneration Research

Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload

(2020) Lisa J. Routhe et al.   GLIA

Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis

(2020) Nunziata Maio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

(2020) Costanza L. Vallerga et al.   Nature Communications

Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation

(2020) Yuchen Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

(2020) Chaitali Mukherjee et al.   Cell Metabolism

Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells

(2020) Yuxue Shang et al.   CELLULAR SIGNALLING

Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells

(2020) Yiran Sun et al.   MOLECULAR NEUROBIOLOGY

Ferroptosis: Biological Rust of Lipid Membranes

(2020) Behrouz Hassannia et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron and manganese transport in mammalian systems

(2020) Qingli Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron Heterogeneity in Early Active Multiple Sclerosis Lesions

(2020) Mylyne Tham et al.   ANNALS OF NEUROLOGY

Association of Brain Iron Overload With Brain Edema and Brain Atrophy After Intracerebral Hemorrhage

(2020) Ran Liu et al.   Frontiers in Neurology

Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia

(2019) Fari Ryan et al.   Frontiers in Neuroscience

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

(2019) Maria Quiles del Rey et al.   Frontiers in Neuroscience

Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome

(2019) Gregory Costain et al.   BRAIN

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Astroglial and microglial contributions to iron metabolism disturbance in Parkinson's disease

(2018) Ning Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Nexus between mitochondrial function, iron, copper and glutathione in Parkinson's disease

(2018) Jeffrey R. Liddell et al.   NEUROCHEMISTRY INTERNATIONAL

Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain

(2018) Jin A. Shin et al.   NEUROPHARMACOLOGY

Ceruloplasmin in Parkinson's disease and the nonmotor symptoms

(2018) Xuemei Zhao et al.   Brain and Behavior

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

(2018) Nuria DeGregorio-Rocasolano et al.   Redox Biology

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

(2018) Zhuwei Zhang et al.   BRAIN RESEARCH

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases

(2018) Mingzhu Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

(2018) Lars Devisscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Che-Lin Hu et al.   JOURNAL OF NEUROCHEMISTRY

Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury

(2018) Hongwei Liu et al.   Translational Stroke Research

Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury

(2018) Yan Zhang et al.   BRAIN RESEARCH

Ferritin, cellular iron storage and regulation

(2017) Paolo Arosio et al.   IUBMB LIFE

Absence of system xc − on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

(2017) Ellen Merckx et al.   Journal of Neuroinflammation

Oxidative Injury and Iron Redistribution Are Pathological Hallmarks of Marmoset Experimental Autoimmune Encephalomyelitis

(2017) Jordon Dunham et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

An altered blood–brain barrier contributes to brain iron accumulation and neuroinflammation in the 6-OHDA rat model of Parkinson’s disease

(2017) Sonia Olmedo-Díaz et al.   NEUROSCIENCE

From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis

(2017) Thomas R. L. Klei et al.   Frontiers in Immunology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging

(2016) Assunta Dal-Bianco et al.   ACTA NEUROPATHOLOGICA

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions

(2016) Hans Lassmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Toll-Like Receptor 4/MyD88–Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral HemorrhageClinical Perspective

(2016) Xiao-Yi Xiong et al.   CIRCULATION

Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis

(2016) Itzy E. Morales Pantoja et al.   JOURNAL OF NEUROCHEMISTRY

Role of hepcidin and its downstream proteins in early brain injury after experimental subarachnoid hemorrhage in rats

(2016) Guanping Tan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Brain Iron Metabolism Dysfunction in Parkinson’s Disease

(2016) Hong Jiang et al.   MOLECULAR NEUROBIOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Cellular and subcellular oxidative stress parameters following severe spinal cord injury

(2016) Nishant P. Visavadiya et al.   Redox Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

MRI Susceptibility Changes Suggestive of Iron Deposition in the Thalamus after Ischemic Stroke

(2015) Ellis S. van Etten et al.   CEREBROVASCULAR DISEASES

Is There a Link Between Changes in Levels of Hepcidin and Stroke?

(2015) Julia Petrova et al.   Clinical Laboratory

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

(2015) Min Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Iron and Neurodegeneration: Is Ferritinophagy the Link?

(2015) Giorgio Biasiotto et al.   MOLECULAR NEUROBIOLOGY

Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid

(2015) Marco Barbariga et al.   Molecular Neurodegeneration

Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation

(2015) Juan G. Zarruk et al.   NEUROBIOLOGY OF DISEASE

Possible involvement of iron-induced oxidative insults in neurodegeneration

(2015) Takeshi Asano et al.   NEUROSCIENCE LETTERS

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Researching glutamate – induced cytotoxicity in different cell lines: a comparative/collective analysis/study

(2015) Aristeidis A. Kritis et al.   Frontiers in Cellular Neuroscience

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier

(2015) Ryan C. McCarthy et al.   Frontiers in Molecular Neuroscience

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

(2014) Cornelia Schuh et al.   ACTA NEUROPATHOLOGICA

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration

(2014) Dario Finazzi et al.   ARCHIVES OF TOXICOLOGY

Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism

(2014) Justin S. Bickford et al.   BRAIN RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Mammalian iron–sulphur proteins: novel insights into biogenesis and function

(2014) Tracey A. Rouault   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Aceruloplasminemia

(2014) Hiroaki Miyajima   NEUROPATHOLOGY

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

(2014) Jason Howitt et al.   PLoS One

Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments

(2014) Kimberly B. Zumbrennen-Bullough et al.   PLoS One

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

The IRP/IRE system in vivo: insights from mouse models

(2014) Nicole Wilkinson et al.   Frontiers in Pharmacology

Special delivery: distributing iron in the cytosol of mammalian cells

(2014) Caroline C. Philpott et al.   Frontiers in Pharmacology

Iron and neurodegeneration in the multiple sclerosis brain

(2013) Simon Hametner et al.   ANNALS OF NEUROLOGY

Increased Carbonylation, Protein Aggregation and Apoptosis in the Spinal Cord of Mice with Experimental Autoimmune Encephalomyelitis

(2013) Anushka Dasgupta et al.   ASN Neuro

6-Hydroxydopamine promotes iron traffic in primary cultured astrocytes

(2013) Hao-Yun Zhang et al.   BIOMETALS

Disease-specific molecular events in cortical multiple sclerosis lesions

(2013) Marie Therese Fischer et al.   BRAIN

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders

(2013) H. Nam et al.   HAEMATOLOGICA

Ferroportin and Exocytoplasmic Ferroxidase Activity Are Required for Brain Microvascular Endothelial Cell Iron Efflux

(2013) Ryan C. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions

(2013) Veela Mehta et al.   PLoS One

The Amyloid Precursor Protein (APP) Does Not Have a Ferroxidase Site in Its E2 Domain

(2013) Kourosh Honarmand Ebrahimi et al.   PLoS One

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Reduced Antioxidant Defense and Increased Oxidative Stress in Spinal Cord Injured Patients

(2012) Nasser Ezzathkah Bastani et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1

(2012) Khizr I. Rathore et al.   GLIA

Diffusely Abnormal White Matter in Multiple Sclerosis: Further Histologic Studies Provide Evidence for a Primary Lipid Abnormality With Neurodegeneration

(2012) Cornelia Laule et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Iron Efflux from Astrocytes Plays a Role in Remyelination

(2012) K. Schulz et al.   JOURNAL OF NEUROSCIENCE

Ferritin Stimulates Oligodendrocyte Genesis in the Adult Spinal Cord and Can Be Transferred from Macrophages to NG2 Cells In Vivo

(2012) D. L. Schonberg et al.   JOURNAL OF NEUROSCIENCE

Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolutionex vivoandin vivoMRI

(2012) Linda V. Blomster et al.   NMR IN BIOMEDICINE

1B/(−)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310

(2012) Rosaria Ingrassia et al.   PLoS One

A Synthetic Peptide with the Putative Iron Binding Motif of Amyloid Precursor Protein (APP) Does Not Catalytically Oxidize Iron

(2012) Kourosh Honarmand Ebrahimi et al.   PLoS One

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

H-ferritin is the major source of iron for oligodendrocytes

(2011) Bozho Todorich et al.   GLIA

Increased expression of cystine/glutamate antiporter in multiple sclerosis

(2011) Olatz Pampliega et al.   Journal of Neuroinflammation

Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter

(2011) K. Schulz et al.   JOURNAL OF NEUROSCIENCE

Ceruloplasmin Oxidation, a Feature of Parkinson's Disease CSF, Inhibits Ferroxidase Activity and Promotes Cellular Iron Retention

(2011) S. Olivieri et al.   JOURNAL OF NEUROSCIENCE

Friedreich's ataxia: Pathology, pathogenesis, and molecular genetics

(2011) Arnulf H. Koeppen   JOURNAL OF THE NEUROLOGICAL SCIENCES

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

(2011) Hui Ding et al.   PLoS One

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

(2011) Suh Young Jeong et al.   PLoS One

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition

(2010) Govindaiah Vinukonda et al.   BRAIN

Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage

(2010) Mai Chen et al.   BRAIN RESEARCH

Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity

(2010) Jennifer L. Berard et al.   GLIA

New Strategy of Functional Analysis of PHGPx Knockout Mice Model Using Transgenic Rescue Method and Cre-LoxP System

(2010) Hirotaka Imai   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

Pathological basis of diffusely abnormal white matter: insights from magnetic resonance imaging and histology

(2010) Cornelia Laule et al.   Multiple Sclerosis Journal

Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease

(2009) Ning Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson’s disease

(2009) K. J. Bharucha et al.   JOURNAL OF NEUROLOGY

Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

(2009) S. Y. Jeong et al.   JOURNAL OF NEUROSCIENCE

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Iron, the substantia nigra and related neurological disorders

(2008) Amanda M. Snyder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Microglia and astroglia prevent oxidative stress-induced neuronal cell death: Implications for aceruloplasminemia

(2008) Satoru Oshiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Oligodendrocytes and myelination: The role of iron

(2008) Bozho Todorich et al.   GLIA

Acyl-CoA:Lysophospholipid Acyltransferases

(2008) Hideo Shindou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceruloplasmin Protects Injured Spinal Cord from Iron-Mediated Oxidative Damage

(2008) K. I. Rathore et al.   JOURNAL OF NEUROSCIENCE

Hepcidin Regulation of Iron Transport

(2008) James F. Collins et al.   JOURNAL OF NUTRITION

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

(2008) Shuzhen Zhang et al.   NEUROBIOLOGY OF AGING

Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin

(2008) Raymond F. Regan et al.   NEUROBIOLOGY OF DISEASE

Midbrain iron content in early Parkinson disease: A potential biomarker of disease status

(2008) W. R. W. Martin et al.   NEUROLOGY

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Regulation of Hepcidin and Its Effects on Systemic and Cellular Iron Metabolism

(2008) M. D. Fleming   Hematology-American Society of Hematology Education Program