Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis

Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention

(2015) Magdalena Bugno et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Spinal cord MRI in multiple sclerosis—diagnostic, prognostic and clinical value

(2015) Hugh Kearney et al.   Nature Reviews Neurology

Nrf2 Activation in Astrocytes Contributes to Spinal Cord Ischemic Tolerance Induced by Hyperbaric Oxygen Preconditioning

(2014) Jiajun Xu et al.   JOURNAL OF NEUROTRAUMA

Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway

(2014) Young-Sam Keum et al.   MOLECULES

Efficacy and safety of delayed-release dimethyl fumarate in patients newly diagnosed with relapsing–remitting multiple sclerosis (RRMS)

(2014) Ralf Gold et al.   Multiple Sclerosis Journal

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Increased Carbonylation, Protein Aggregation and Apoptosis in the Spinal Cord of Mice with Experimental Autoimmune Encephalomyelitis

(2013) Anushka Dasgupta et al.   ASN Neuro

The fumaric acid ester BG-12: a new option in MS therapy

(2013) De-Hyung Lee et al.   Expert Review of Neurotherapeutics

A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells

(2013) Riyako Terazawa et al.   PHARMACOLOGICAL RESEARCH

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1

(2011) Shao Xia Lin et al.   ASN Neuro

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of the System x−C cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures

(2011) Todd Michael Seib et al.   GLIA

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Accumulation of protein carbonyls within cerebellar astrocytes in murine experimental autoimmune encephalomyelitis

(2010) Jianzheng Zheng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouse

(2010) G. Leung et al.   NEUROSCIENCE

Effects of Fumaric Acids on Cuprizone Induced Central Nervous System De- and Remyelination in the Mouse

(2010) Darius Moharregh-Khiabani et al.   PLoS One

Identification of major S-nitrosylated proteins in murine experimental autoimmune encephalomyelitis

(2009) Oscar A. Bizzozero et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury

(2009) Wei Jin et al.   MEDIATORS OF INFLAMMATION

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

(2009) Delinda A. Johnson et al.   TOXICOLOGICAL SCIENCES

The Antioxidant Response Element and Oxidative Stress Modifiers in Airway Diseases

(2008) Sekhar Reddy   CURRENT MOLECULAR MEDICINE

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Cytoskeletal protein carbonylation and degradation in experimental autoimmune encephalomyelitis

(2008) Suzanne M. Smerjac et al.   JOURNAL OF NEUROCHEMISTRY

Intracellular glutathione mediates the denitrosylation of protein nitrosothiols in the rat spinal cord

(2008) Jorge M. Romero et al.   JOURNAL OF NEUROSCIENCE RESEARCH