Researching glutamate – induced cytotoxicity in different cell lines: a comparative/collective analysis/study

Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure

(2015) Marta Obara-Michlewska et al.   NEUROCHEMISTRY INTERNATIONAL

Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells

(2014) Madhavan Nampoothiri et al.   BEHAVIOURAL NEUROLOGY

Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure

(2014) Lei Shang et al.   BMC NEUROSCIENCE

Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes

(2014) Pratap Karki et al.   GLIA

Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization

(2014) E. Foran et al.   GLIA

Modulation of Glutamate Transport and Receptor Binding by Glutamate Receptor Antagonists in EAE Rat Brain

(2014) Grzegorz Sulkowski et al.   PLoS One

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model

(2013) Nailya S Gliyazova et al.   BMC NEUROSCIENCE

Gene profiling identifies commonalities in neuronal pathways in excitotoxicity: Evidence favouring cell cycle re-activation in concert with oxidative stress

(2013) Minghui Jessica Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

Influences of the circadian clock on neuronal susceptibility to excitotoxicity

(2013) Sumedha W. Karmarkar et al.   Frontiers in Physiology

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release

(2012) Stephen M McMullan et al.   ASN Neuro

Neuroprotective cyclopentenone prostaglandins up-regulate neurotrophic factors in C6 glioma cells

(2012) Yoko Hirata et al.   BRAIN RESEARCH

The Glutamate Aspartate Transporter (GLAST) Mediates l-Glutamate-Stimulated Ascorbate-Release Via Swelling-Activated Anion Channels in Cultured Neonatal Rodent Astrocytes

(2012) Darius J. R. Lane et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function

(2012) A. Voulgari-Kokota et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective Effects of Germinated Brown Rice against Hydrogen Peroxide Induced Cell Death in Human SH-SY5Y Cells

(2012) Norsharina Ismail et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress

(2012) Vivek K. Gupta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

(2012) Jie Fang et al.   Journal of Neuroinflammation

Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway

(2012) Benxu Cheng et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of 18-kDa translocator protein knockdown on gene expression of glutamate receptors, transporters, and metabolism, and on cell viability affected by glutamate

(2012) Leo Veenman et al.   Pharmacogenetics and Genomics

N-acetylcysteine Protects against Apoptosis through Modulation of Group I Metabotropic Glutamate Receptor Activity

(2012) Lili Sun et al.   PLoS One

Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium

(2012) Santosh Kumari et al.   PLoS One

Khz (Fusion of Ganoderma lucidum and Polyporus umbellatus Mycelia) Induces Apoptosis by Increasing Intracellular Calcium Levels and Activating JNK and NADPH Oxidase-Dependent Generation of Reactive Oxygen Species

(2012) Tae Hwan Kim et al.   PLoS One

Protective Role of STAT3 in NMDA and Glutamate-Induced Neuronal Death: Negative Regulatory Effect of SOCS3

(2012) Keun W. Park et al.   PLoS One

Neuroprotective Actions of Methylene Blue and Its Derivatives

(2012) Ethan Poteet et al.   PLoS One

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain

(2012) Thomas M. Piers et al.   Frontiers in Pharmacology

Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity

(2011) Jia Wei Zhu et al.   BIOCHIMIE

Riluzole-induced glial cell line-derived neurotrophic factor production is regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells

(2011) Mami Tsuchioka et al.   BRAIN RESEARCH

Photodynamic therapy leads to death of C6 glioma cells partly through AMPAR

(2011) Peng Du et al.   BRAIN RESEARCH

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of the System x−C cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures

(2011) Todd Michael Seib et al.   GLIA

Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,6′-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala

(2011) Yuan Hu et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency

(2011) Jenq-Lin Yang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Activation of Adenosine A2A Receptor Up-Regulates BDNF Expression in Rat Primary Cortical Neurons

(2011) Se Jin Jeon et al.   NEUROCHEMICAL RESEARCH

The role of glutamate in neuronal ischemic injury: the role of spark in fire

(2011) Botros B. Kostandy   NEUROLOGICAL SCIENCES

Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity

(2011) Jing Chen et al.   NEUROSCIENCE LETTERS

Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress

(2011) Kaori Suyama et al.   NEUROSCIENCE LETTERS

Selective mGluR1 Antagonist EMQMCM Inhibits the Kainate-Induced Excitotoxicity in Primary Neuronal Cultures and in the Rat Hippocampus

(2011) Maria Śmiałowska et al.   NEUROTOXICITY RESEARCH

Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca2+ influx

(2011) Shuwei Ma et al.   NEUROTOXICOLOGY

Overview of glutamatergic neurotransmission in the nervous system

(2011) Mark J. Niciu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

ERK/MAPK Is Essential for Endogenous Neuroprotection in SCN2.2 Cells

(2011) Sumedha W. Karmarkar et al.   PLoS One

Proteases Inhibition Assessment on PC12 and NGF Treated Cells after Oxygen and Glucose Deprivation Reveals a Distinct Role for Aspartyl Proteases

(2011) Aristidis Kritis et al.   PLoS One

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Molecular and cellular mechanisms of excitotoxic neuronal death

(2010) Yan Wang et al.   APOPTOSIS

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

(2010) Shankar Sadasivan et al.   BMC NEUROSCIENCE

The role of PARP activation in glutamate-induced necroptosis in HT-22 cells

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

(2010) S Tobaben et al.   CELL DEATH AND DIFFERENTIATION

Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies

(2010) A.H. Dahlmann-Noor et al.   DRUG DISCOVERY TODAY

Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7 cells

(2010) Truong LX Nguyen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Suprachiasmatic nucleus neurons display endogenous resistance to excitotoxicity

(2010) Kathleen Bottum et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Glutamate Differently Modulates Metabotropic Glutamate Receptors in Neuronal and Glial Cells

(2010) Carlos Alberto Castillo et al.   NEUROCHEMICAL RESEARCH

Glutamate differently modulates excitatory and inhibitory adenosine receptors in neuronal and glial cells

(2010) Carlos Alberto Castillo et al.   NEUROCHEMISTRY INTERNATIONAL

l-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway

(2010) X. Di et al.   NEUROSCIENCE

Nitric oxide and neuronal death

(2010) Guy C. Brown   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation

(2010) Shan Lu et al.   TOXICOLOGY

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

(2010) A Ruiz et al.   Cell Death & Disease

Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage

(2010) Zhong-Wei Sun et al.   Neuroscience Bulletin

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death

(2009) Julia Grohm et al.   BRAIN BEHAVIOR AND IMMUNITY

Transcriptional regulation of PSA-NCAM expression by NMDA receptor activation in RA-differentiated C6 glioma cultures

(2009) Jaspreet Singh et al.   BRAIN RESEARCH BULLETIN

Clovamide and rosmarinic acid induce neuroprotective effects inin vitromodels of neuronal death

(2009) S Fallarini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular phenotypes of human model neurons (NT2) after differentiation in aggregate culture

(2009) Grzegorz Podrygajlo et al.   CELL AND TISSUE RESEARCH

Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells

(2009) Masayuki Fukui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective actions of sex steroids in Parkinson’s disease

(2009) Mélanie Bourque et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation

(2009) Nilkantha Sen et al.   NEURON

Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells

(2009) Kittikun Viwatpinyo et al.   NEUROSCIENCE LETTERS

When apoptosis meets autophagy: deciding cell fate after trauma and sepsis

(2009) Ya-Ching Hsieh et al.   TRENDS IN MOLECULAR MEDICINE

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Hydrogen sulfide protects astrocytes against H2O2-induced neural injury via enhancing glutamate uptake

(2008) Ming Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection

(2008) Clara De Palma et al.   JOURNAL OF NEUROCHEMISTRY

All-trans retinoic acid arrests neuroblastoma cells in a dormant state. Subsequent nerve growth factor/brain-derived neurotrophic factor treatment adds modest benefit

(2008) Grigore Cernaianu et al.   JOURNAL OF PEDIATRIC SURGERY

Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock

(2008) Ruifeng Cao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

(2008) Nilkantha Sen et al.   NATURE CELL BIOLOGY

Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype

(2008) Toshiaki Kume et al.   NEUROSCIENCE LETTERS

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

(2008) Kimberly R. Byrnes et al.   Neurotherapeutics

Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors

(2005) Paul M Lea et al.   BRITISH JOURNAL OF PHARMACOLOGY