Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

Cholesterol load of microglia: Contribution of membrane architecture changes to neurotoxic power?

(2013) Lucia Račková   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis

(2013) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disease-specific molecular events in cortical multiple sclerosis lesions

(2013) Marie Therese Fischer et al.   BRAIN

Toll-like Receptor 2 Mediates Peripheral Nerve Injury-induced NADPH Oxidase 2 Expression in Spinal Cord Microglia

(2013) Hyoungsub Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse

(2013) Sebastian M. Fiebiger et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Therapies for multiple sclerosis: translational achievements and outstanding needs

(2013) Aiden Haghikia et al.   TRENDS IN MOLECULAR MEDICINE

Interleukin-13/-4-Induced Oxidative Stress Contributes to Death of Hippocampal Neurons in Aβ1-42-Treated Hippocampus In Vivo

(2012) J.H. Nam et al.   ANTIOXIDANTS & REDOX SIGNALING

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

(2012) James Kolasinski et al.   BRAIN

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

(2012) Jack van Horssen et al.   Journal of Neuroinflammation

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

A self-propelling cycle mediated by reactive oxide species and nitric oxide exists in LPS-activated microglia

(2012) Zhang Lijia et al.   NEUROCHEMISTRY INTERNATIONAL

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

(2012) Zoe Fonseca-Kelly et al.   Frontiers in Neurology

Systemic inflammation induces axon injury during brain inflammation

(2011) Beatriz Moreno et al.   ANNALS OF NEUROLOGY

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

(2011) Era Taoufik et al.   BRAIN

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination

(2011) Miriam E. Van Strien et al.   GLIA

Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia

(2011) Youichirou Higashi et al.   GLIA

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation

(2011) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter

(2011) K. Schulz et al.   JOURNAL OF NEUROSCIENCE

Peroxidation of lipoproteins in multiple sclerosis

(2011) Gianna Ferretti et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Review: The architecture of inflammatory demyelinating lesions: implications for studies on pathogenesis

(2011) H. Lassmann   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

Antibody-mediated demyelination in experimental allergic encephalomyelitis is independent of complement membrane attack complex formation

(2010) S. PIDDLESDEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Modified phospholipids as anti-inflammatory compounds

(2010) Erez Feige et al.   CURRENT OPINION IN LIPIDOLOGY

Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis

(2010) Romana Höftberger et al.   GLIA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

IL-13-Induced Oxidative Stress via Microglial NADPH Oxidase Contributes to Death of Hippocampal Neurons In Vivo

(2009) K. W. Park et al.   JOURNAL OF IMMUNOLOGY

Multiple sclerosis therapeutics: Unexpected outcomes clouding undisputed successes

(2009) H. Wiendl et al.   NEUROLOGY

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

(2008) Kryslaine O. Lopes et al.   GLIA

Ceruloplasmin Protects Injured Spinal Cord from Iron-Mediated Oxidative Damage

(2008) K. I. Rathore et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

Zinc Triggers Microglial Activation

(2008) T. M. Kauppinen et al.   JOURNAL OF NEUROSCIENCE