DNA‐Damage‐Response‐Targeting Mitochondria‐Activated Multifunctional Prodrug Strategy for Self‐Defensive Tumor Therapy

Nanoscale Metal–Organic Layers Detect Mitochondrial Dysregulation and Chemoresistance via Ratiometric Sensing of Glutathione and pH

(2021) Xiang Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Floxuridine Oligomers Activated under Hypoxic Environment

(2021) Kunihiko Morihiro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics

(2021) Xiaoyuan Ji et al.   Nature Communications

Highly Stable Silica-Coated Bismuth Nanoparticles Deliver Tumor Microenvironment-Responsive Prodrugs to Enhance Tumor-Specific Photoradiotherapy

(2021) Huandong Xiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy

(2021) Na Kong et al.   Nature Communications

Targeted chemotherapy overcomes drug resistance in melanoma

(2020) Jingyin Yue et al.   GENES & DEVELOPMENT

CCND1 silencing suppresses liver cancer stem cell differentiation and overcomes 5-Fluorouracil resistance in hepatocellular carcinoma

(2020) Hao Ding et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes

(2020) Sabrina Blondy et al.   CANCER SCIENCE

A tubular DNA nanodevice as a siRNA/chemo‐drug co‐delivery vehicle for combined cancer therapy

(2020) Zhaoran Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PP2A Regulates Phosphorylation-Dependent Isomerization of Cytoplasmic and Mitochondrial-Associated ATR by Pin1 in DNA Damage Responses

(2020) Yetunde Makinwa et al.   Frontiers in Cell and Developmental Biology

DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy

(2020) Larissa Costa de Almeida et al.   Cancer Genetics

Guiding Drugs to Target- Harboring Organelles: Stretching Drug-Delivery to a Higher Level of Resolution

(2019) Micha Fridman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

(2019) Sona Vodenkova et al.   PHARMACOLOGY & THERAPEUTICS

p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

(2019) Consuelo Pitolli et al.   Cancers

Polymeric Nanoparticles with a Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for In Vivo Drug Monitoring and Synergistic Cancer Therapy

(2018) Fuwu Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Supramolecular Polymer-Based Nanomedicine: High Therapeutic Performance and Negligible Long-Term Immunotoxicity

(2018) Guocan Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The expanding role of prodrugs in contemporary drug design and development

(2018) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting PP2A in cancer: Combination therapies

(2018) Sahar Mazhar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug

(2018) Amit Sharma et al.   Chem

A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer

(2017) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

(2017) Elisa Ferrari et al.   MOLECULAR CELL

Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma

(2017) et al.   Cancers

Intracellular delivery of chemical probes using a glutathione-responsive traceless tag

(2016) Eriko Aoyama et al.   CHEMICAL COMMUNICATIONS

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

(2016) Jadd Shelton et al.   CHEMICAL REVIEWS

PP2A as a master regulator of the cell cycle

(2016) Nathan Wlodarchak et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Enhancing Therapeutic Efficacy of Cisplatin by Blocking DNA Damage Repair

(2016) Yuwei Cong et al.   ACS Medicinal Chemistry Letters

Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

(2015) Peng Lv et al.   Oncotarget

Mitochondrial Induced and Self-Monitored Intrinsic Apoptosis by Antitumor Theranostic Prodrug: In Vivo Imaging and Precise Cancer Treatment

(2014) Rajesh Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemotherapy induced DNA damage response

(2013) Derek Woods et al.   CANCER BIOLOGY & THERAPY

Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications

(2013) Min Hee Lee et al.   CHEMICAL REVIEWS

Tunable Thioesters as “Reduction” Responsive Functionality for Traceless Reversible Protein PEGylation

(2013) Jianwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

(2013) S. Kalghatgi et al.   Science Translational Medicine

Response to DNA damage: why do we need to focus on protein phosphatases?

(2013) Midori Shimada et al.   Frontiers in Oncology

Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways

(2012) Gernot Walter et al.   CELL CYCLE

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

(2012) Christian Bailly   CHEMICAL REVIEWS

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Ratiometric Detection of Mitochondrial Thiols with a Two-Photon Fluorescent Probe

(2011) Chang Su Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

(2011) Henrik Sahlin Pettersen et al.   NUCLEIC ACIDS RESEARCH

Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil

(2011) Liyi Geng et al.   PLoS One

Serine/threonine phosphatases in the DNA damage response and cancer

(2010) A Peng et al.   ONCOGENE

Targeting the DNA Damage Response in Cancer

(2009) Mats Ljungman   CHEMICAL REVIEWS

Perspectives in Cell Cycle Regulation: Lessons from an Anoxic Vertebrate

(2009) Kyle Biggar et al.   CURRENT GENOMICS

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

(2009) Jie Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dual role of Cdk2 in DNA damage response

(2009) Ande Satyanarayana et al.   Cell Division

Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response

(2008) Howard R. Mellor et al.   PHARMACOLOGY