Serine/threonine phosphatases in the DNA damage response and cancer

Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage

(2011) Alyson K. Freeman et al.   CELL CYCLE

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage

(2010) Luigi Carlessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphatase inhibition and cell survival after DNA damage induced by radiation

(2010) Julie Hamilton et al.   CANCER BIOLOGY & THERAPY

Wip1 Directly Dephosphorylates  -H2AX and Attenuates the DNA Damage Response

(2010) H. Cha et al.   CANCER RESEARCH

FUNCTIONAL DIVERSITY OF MAMMALIAN TYPE 2C PROTEIN PHOSPHATASE ISOFORMS: NEW TALES FROM AN OLD FAMILY

(2010) Gang Lu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Repo-Man Controls a Protein Phosphatase 1-Dependent Threshold for DNA Damage Checkpoint Activation

(2010) Aimin Peng et al.   CURRENT BIOLOGY

Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

(2010) Sung-Hwan Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates  -H2AX

(2010) P. Douglas et al.   MOLECULAR AND CELLULAR BIOLOGY

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

(2010) Dong-Hyun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

(2010) L Macůrek et al.   ONCOGENE

Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response

(2010) Y Yan et al.   ONCOGENE

A B56γ mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A

(2010) G P Shouse et al.   ONCOGENE

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair

(2009) E. Bolderson et al.   CLINICAL CANCER RESEARCH

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Loss of Wip1 Sensitizes Cells to Stress- and DNA Damage-induced Apoptosis

(2009) Yun Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress

(2009) J. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Dephosphorylation of  H2A by Glc7/Protein Phosphatase 1 Promotes Recovery from Inhibition of DNA Replication

(2009) M. Bazzi et al.   MOLECULAR AND CELLULAR BIOLOGY

PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53

(2009) J. Mi et al.   MOLECULAR CANCER THERAPEUTICS

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Activation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6

(2009) Jun Mi et al.   PLoS One

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

(2009) Jie Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint

(2008) Shinichiro Nakada et al.   EMBO REPORTS

Distinct Phosphatases Mediate the Deactivation of the DNA Damage Checkpoint Kinase Rad53

(2008) Anna Travesa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

(2008) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY

A Novel ATM-Dependent Pathway Regulates Protein Phosphatase 1 in Response to DNA Damage

(2008) X. Tang et al.   MOLECULAR AND CELLULAR BIOLOGY

A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication

(2008) Dipanjan Chowdhury et al.   MOLECULAR CELL

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

(2008) E. Soutoglou et al.   SCIENCE

DNA-damage checkpoints: location, location, location

(2008) Jamie L. Wood et al.   TRENDS IN CELL BIOLOGY