5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

(2019) Weilong Yao et al.   Cancer Cell International

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

(2018) Al B. Benson et al.   Journal of the National Comprehensive Cancer Network

5-FU therapeutic drug monitoring as a valuable option to reduce toxicity in patients with gastrointestinal cancer

(2018) Katarzyna Morawska et al.   Oncotarget

Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance

(2018) Ziqian Li et al.   Cancer Research and Treatment

Emerging Systemic Therapies for Colorectal Cancer

(2018) John Krauss et al.   Clinics in Colon and Rectal Surgery

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin

(2017) Jia Han et al.   EXPERIMENTAL CELL RESEARCH

CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk

(2017) Pinjia Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The extracellular domain of E cadherin linked to invasiveness in colorectal cancer: a new resistance and relapses monitoring serum-bio marker?

(2017) Niki Christou et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cells

(2017) Y Shen et al.   PHARMACOGENOMICS JOURNAL

MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase

(2017) Weidong Xu et al.   Oncology Letters

The role of GLI1 for 5-Fu resistance in colorectal cancer

(2017) Lining Zhang et al.   Cell and Bioscience

HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins

(2017) Lei Sun et al.   Journal of Cancer

Identification of Predictive DNA Methylation Biomarkers for Chemotherapy Response in Colorectal Cancer

(2017) Rashidah Baharudin et al.   Frontiers in Pharmacology

CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer

(2017) Xinfeng Yu et al.   Scientific Reports

Macrophages induce resistance to 5-fluorouracil chemotherapy in colorectal cancer through the release of putrescine

(2016) Xuan Zhang et al.   CANCER LETTERS

Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4

(2016) Po-Lin Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Suppression of TWIST1 enhances the sensitivity of colon cancer cells to 5-fluorouracil

(2016) Monika Sakowicz-Burkiewicz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

High Infiltration of Tumor-Associated Macrophages Influences Poor Prognosis in Human Gastric Cancer Patients, Associates With the Phenomenon of EMT

(2016) Jia Zhang et al.   MEDICINE

Gap junction composed of connexin43 modulates 5-fluorouracil, oxaliplatin and irinotecan resistance on colorectal cancers

(2016) Zhao-Wei Zou et al.   Molecular Medicine Reports

Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in colon cancer SW480 cells

(2016) Lin Lv et al.   TUMOR BIOLOGY

Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells

(2016) Samuel Gonçalves-Ribeiro et al.   Oncotarget

FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10

(2016) Tao Xie et al.   Oncotarget

The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells

(2016) Gabriele Romano et al.   Oncotarget

MicroRNA-204 modulates colorectal cancer cell sensitivity in response to 5-fluorouracil-based treatment by targeting high mobility group protein A2

(2016) Haijun Wu et al.   Biology Open

miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2

(2016) Qingguo Li et al.   Scientific Reports

IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer

(2015) K Abiko et al.   BRITISH JOURNAL OF CANCER

MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells

(2015) Honghe Zhang et al.   CANCER LETTERS

Elevated microRNA-23a Expression Enhances the Chemoresistance of Colorectal Cancer Cells with Microsatellite Instability to 5-Fluorouracil by Directly Targeting ABCF1

(2015) Xiang Li et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

PHD1 regulates p53-mediated colorectal cancer chemoresistance

(2015) S. Deschoemaeker et al.   EMBO Molecular Medicine

Exploiting a novel miR-519c–HuR–ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer

(2015) Kenneth K.W. To et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD

(2015) Jie Chai et al.   IUBMB LIFE

MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10

(2015) Ye Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of interleukin-8 (CXCL8) and CXCR2 in acquired chemoresistance of human colorectal carcinoma cells HCT116

(2015) Daiva Dabkeviciene et al.   MEDICAL ONCOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade

(2015) BINHAO ZHANG et al.   ONCOLOGY REPORTS

Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity

(2015) Tao Hu et al.   PHYTOMEDICINE

MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer

(2015) Y Zhang et al.   Cell Death & Disease

Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells

(2015) XIAO-QIAN ZHAO et al.   Oncology Letters

Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages

(2015) Ling Ding et al.   Oncotarget

Overexpression of MicroRNA-122 Re-sensitizes 5-FU-Resistant Colon Cancer Cells to 5-FU Through the Inhibition of PKM2 In Vitro and In Vivo

(2014) Jinxia He et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5-fluorouracil on the HT-29 colon cancer cell line

(2014) ALEXANDER HEDBRANT et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

microRNAs miR-27a and miR-27b Directly Regulate Liver Dihydropyrimidine Dehydrogenase Expression through Two Conserved Binding Sites

(2014) S. M. Offer et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil

(2014) XIANGYONG LI et al.   Molecular Medicine Reports

Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer

(2014) R C Turkington et al.   Cell Death & Disease

Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

(2013) Jun Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FGFR4 Promotes Stroma-Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer

(2013) R. Liu et al.   CANCER RESEARCH

TGF-β: An emerging player in drug resistance

(2013) Diede Brunen et al.   CELL CYCLE

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

MicroRNA-23a Antisense Enhances 5-Fluorouracil Chemosensitivity Through APAF-1/Caspase-9 Apoptotic Pathway in Colorectal Cancer Cells

(2013) Jingli Shang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A

(2013) Fiorenza Lotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coordinate Transcriptional and Translational Repression of p53 by TGF-β1 Impairs the Stress Response

(2013) Fernando J. López-Díaz et al.   MOLECULAR CELL

The Tumor Microenvironment: A Pitch for Multiple Players

(2013) Giovanna Schiavoni et al.   Frontiers in Oncology

MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells

(2012) Naohiro Nishida et al.   ANNALS OF SURGICAL ONCOLOGY

The emerging multiple roles of nuclear Akt

(2012) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The β6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer

(2012) Song Liu et al.   CANCER LETTERS

Anti-tumor immunity: Myeloid leukocytes control the immune landscape

(2012) Melanie R. Rutkowski et al.   CELLULAR IMMUNOLOGY

Cell fusion promotes chemoresistance in metastatic colon carcinoma

(2012) V Carloni et al.   ONCOGENE

Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer

(2012) M Griffith et al.   PHARMACOGENOMICS JOURNAL

Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines

(2011) H. Chai et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Epigenetics and chemoresistance in colorectal cancer: An opportunity for treatment tailoring and novel therapeutic strategies

(2011) Francesco Crea et al.   DRUG RESISTANCE UPDATES

P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance

(2011) M A de la Cruz-Morcillo et al.   ONCOGENE

The Inflammatory Microenvironment in Colorectal Neoplasia

(2011) Mairi H. McLean et al.   PLoS One

miR-192/miR-215 Influence 5-Fluorouracil Resistance through Cell Cycle-Mediated Mechanisms Complementary to Its Post-transcriptional Thymidilate Synthase Regulation

(2010) Valentina Boni et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells

(2009) Pedro M. Borralho et al.   FEBS Journal

Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells

(2009) William Fazzone et al.   INTERNATIONAL JOURNAL OF CANCER

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance

(2009) R. Humeniuk et al.   MOLECULAR CANCER THERAPEUTICS

p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

(2008) C. J. Braun et al.   CANCER RESEARCH

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

(2008) Ning Zhang et al.   MOLECULES