PP2A as a master regulator of the cell cycle

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

(2015) Jaya Sangodkar et al.   FEBS Journal

Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner

(2015) Jennifer B. Jackson et al.   NEOPLASIA

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

(2014) Christian Löw et al.   BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease

(2014) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders

(2014) Jianling Chen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

(2014) Rebecca Dovega et al.   PLoS One

Feedback control of chromosome separation by a midzone Aurora B gradient

(2014) O. Afonso et al.   SCIENCE

PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit

(2014) Nadia Hégarat et al.   PLoS Genetics

A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1

(2013) Hui-Wen Chen et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation

(2013) Nathan Wlodarchak et al.   CELL RESEARCH

Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone

(2013) Feng Guo et al.   CELL RESEARCH

Aurora B Defines Its Own Chromosomal Targeting by Opposing the Recruitment of the Phosphatase Scaffold Repo-Man

(2013) Junbin Qian et al.   CURRENT BIOLOGY

A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A

(2013) Akio Nakashima et al.   FEBS LETTERS

HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction

(2013) Hoanh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function and regulation of serine/threonine phosphatases in the healthy and diseased heart

(2013) Jordi Heijman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

From Simple Bacterial and Archaeal Replicons to Replication N/U-Domains

(2013) Olivier Hyrien et al.   JOURNAL OF MOLECULAR BIOLOGY

The B55  Regulatory Subunit of Protein Phosphatase 2A Mediates Fibroblast Growth Factor-Induced p107 Dephosphorylation and Growth Arrest in Chondrocytes

(2013) V. Kolupaeva et al.   MOLECULAR AND CELLULAR BIOLOGY

The functional interactome landscape of the human histone deacetylase family

(2013) P. Joshi et al.   Molecular Systems Biology

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

(2013) Markku Varjosalo et al.   NATURE METHODS

The SOX2-Interactome in Brain Cancer Cells Identifies the Requirement of MSI2 and USP9X for the Growth of Brain Tumor Cells

(2013) Jesse L. Cox et al.   PLoS One

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics

(2013) Sarah Foerster et al.   PROTEOMICS

Structural basis of protein phosphatase 2A stable latency

(2013) Li Jiang et al.   Nature Communications

The Protein Interaction Landscape of the Human CMGC Kinase Group

(2013) Markku Varjosalo et al.   Cell Reports

BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression

(2013) P. Xu et al.   Biology Open

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer

(2012) Ashok Kumar et al.   CARCINOGENESIS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Coordination of Kinase and Phosphatase Activities by Lem4 Enables Nuclear Envelope Reassembly during Mitosis

(2012) Claudio Asencio et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Protein phosphatases and their regulation in the control of mitosis

(2012) Satoru Mochida et al.   EMBO REPORTS

N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival

(2012) Ronald A. Merrill et al.   FEBS Journal

PP1 and PP2A phosphatases - cooperating partners in modulating retinoblastoma protein activation

(2012) Victoria Kolupaeva et al.   FEBS Journal

Regulatory modules: Coupling protein stability to phopshoregulation during cell division

(2012) Liam J. Holt   FEBS LETTERS

PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates

(2012) Alison Kurimchak et al.   GENE

PTPN14 is required for the density-dependent control of YAP1

(2012) W. Wang et al.   GENES & DEVELOPMENT

Selective Proteasomal Degradation of the B′β Subunit of Protein Phosphatase 2A by the E3 Ubiquitin Ligase Adaptor Kelch-like 15

(2012) Elizabeth A. Oberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation

(2012) Yang Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

(2012) Minsheng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation

(2012) A. Aichem et al.   JOURNAL OF CELL SCIENCE

Phosphorylation network dynamics in the control of cell cycle transitions

(2012) D. Fisher et al.   JOURNAL OF CELL SCIENCE

Emerging roles of RB family: New defense mechanisms against tumor progression

(2012) Paola Indovina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proteomics Strategy to Identify Substrates of LNX, a PDZ Domain-containing E3 Ubiquitin Ligase

(2012) Zhengguang Guo et al.   JOURNAL OF PROTEOME RESEARCH

Phosphoprotein abundance changes in hypertensive cardiac remodeling

(2012) Kumar Kotlo et al.   Journal of Proteomics

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

A high-throughput approach for measuring temporal changes in the interactome

(2012) Anders R Kristensen et al.   NATURE METHODS

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin

(2012) A Mitra et al.   ONCOGENE

Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells

(2012) J-Y Chuang et al.   ONCOGENE

TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity

(2012) Marisa J. Wainszelbaum et al.   PLoS One

Targeted Ubiquitination and Degradation of G-Protein-Coupled Receptor Kinase 5 by the DDB1-CUL4 Ubiquitin Ligase Complex

(2012) Ziyan Wu et al.   PLoS One

The APC/C Inhibitor XErp1/Emi2 Is Essential for Xenopus Early Embryonic Divisions

(2012) T. Tischer et al.   SCIENCE

Charting the Landscape of Tandem BRCT Domain-Mediated Protein Interactions

(2012) N. T. Woods et al.   Science Signaling

Deciphering the retinoblastoma protein phosphorylation code

(2012) Seth M. Rubin   TRENDS IN BIOCHEMICAL SCIENCES

Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate

(2011) Melissa M. Grant   BMB Reports

Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3

(2011) Johnthan Gordon et al.   BMC BIOCHEMISTRY

Phosphorylation of Nup98 by Multiple Kinases Is Crucial for NPC Disassembly during Mitotic Entry

(2011) Eva Laurell et al.   CELL

Tumor suppression by ARF: Gatekeeper and caretaker

(2011) Carmen Dominguez-Brauer et al.   CELL CYCLE

The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85

(2011) Thomas Oellerich et al.   EMBO JOURNAL

TLE1 Modifies the Effects of NOD2 in the Pathogenesis of Crohn's Disease

(2011) Elaine R. Nimmo et al.   GASTROENTEROLOGY

Protein Phosphatase 2A and Neutral Sphingomyelinase 2 Regulate IRAK-1 Protein Ubiquitination and Degradation in Response to Interleukin-1β

(2011) Aneta Dobierzewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of Pathological Hallmark Proteins

(2011) Judit Oláh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host Cell Interactome of HIV-1 Rev Includes RNA Helicases Involved in Multiple Facets of Virus Production

(2011) Souad Naji et al.   MOLECULAR & CELLULAR PROTEOMICS

A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast

(2011) Stacy L. Harvey et al.   MOLECULAR BIOLOGY OF THE CELL

The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1

(2011) Vitali Stanevich et al.   MOLECULAR CELL

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

(2011) Nicolas Bisson et al.   NATURE BIOTECHNOLOGY

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Phosphatases: providing safe passage through mitotic exit

(2011) Claudia Wurzenberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation

(2011) D P Mathiasen et al.   ONCOGENE

Mice lacking phosphatase PP2A subunit PR61/B'  (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3 

(2011) J. V. Louis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

(2010) Eric J. Bennett et al.   CELL

The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment

(2010) Margaret I Arbuckle et al.   EMBO REPORTS

Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres

(2010) Y. Tanno et al.   GENES & DEVELOPMENT

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

(2010) Melissa R. Pitman et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

B55α PP2A Holoenzymes Modulate the Phosphorylation Status of the Retinoblastoma-related Protein p107 and Its Activation

(2010) Girish Jayadeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP-stimulated Protein Phosphatase 2A Activity Associated with Muscle A Kinase-anchoring Protein (mAKAP) Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-specific Phosphodiesterase PDE4D3

(2010) Kimberly L. Dodge-Kafka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP2A interaction with Rb2/p130 mediates translocation of Rb2/p130 into the nucleus in all-Trans retinoic acid-treated ovarian carcinoma cells

(2010) Enkhtsetseg Purev et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal Phosphorylation

(2010) Todd M. Greco et al.   MOLECULAR & CELLULAR PROTEOMICS

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

PP2AT61ɛ Is an Inhibitor of MAP4K3 in Nutrient Signaling to mTOR

(2010) Lijun Yan et al.   MOLECULAR CELL

Shugoshin–PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase

(2010) Tadashi Ishiguro et al.   NATURE CELL BIOLOGY

Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation

(2010) Ryu-Suke Nozawa et al.   NATURE CELL BIOLOGY

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein

(2010) Alexander Hirschi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

Molecular Determinants for PP2A Substrate Specificity: Charged Residues Mediate Dephosphorylation of Tyrosine Hydroxylase by the PP2A/B′ Regulatory Subunit

(2009) Amit Saraf et al.   BIOCHEMISTRY

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

PP2A Antagonizes Phosphorylation of Bazooka by PAR-1 to Control Apical-Basal Polarity in Dividing Embryonic Neuroblasts

(2009) Michael P. Krahn et al.   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Ubiquitin-mediated proteolysis of HuR by heat shock

(2009) Kotb Abdelmohsen et al.   EMBO JOURNAL

The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc

(2009) Hugh K Arnold et al.   EMBO JOURNAL

Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

(2009) Satoru Mochida et al.   EMBO JOURNAL

Protein phosphatase 2A PR130/B″α1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling

(2009) Karen Zwaenepoel et al.   FASEB JOURNAL

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A

(2009) Pekka T. Heikkinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PR55α, a Regulatory Subunit of PP2A, Specifically Regulates PP2A-mediated β-Catenin Dephosphorylation

(2009) Wen Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Structure and Function of the PP2A-Shugoshin Interaction

(2009) Zheng Xu et al.   MOLECULAR CELL

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

(2009) Timo Glatter et al.   Molecular Systems Biology

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Orchestrating nuclear envelope disassembly and reassembly during mitosis

(2009) Stephan Güttinger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle

(2009) Roberta Paolinelli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A

(2009) Ai Takemoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitotic division of the mammalian Golgi apparatus

(2009) Jen-Hsuan Wei et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The origin recognition complex protein family

(2009) Bernard P Duncker et al.   GENOME BIOLOGY

The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members

(2008) Maya Breitman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein phosphatase 2A regulatory subunits and cancer

(2008) Pieter J.A. Eichhorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A

(2008) Yongna Xing et al.   CELL

PKR Regulates B56α-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells

(2008) Vivian R. Ruvolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 2A Is Targeted to Cell Division Control Protein 6 by a Calcium-binding Regulatory Subunit

(2008) Anthony J. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4

(2008) Ginny I. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The α4-containing form of protein phosphatase 2A in liver and hepatic cells

(2008) Sunny J.-S. Yoo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Protein Phosphatase 2A Regulatory Subunits B'  and B'  Mediate Sustained TrkA Neurotrophin Receptor Autophosphorylation and Neuronal Differentiation

(2008) M. J. Van Kanegan et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

(2008) Veerle Janssens et al.   TRENDS IN BIOCHEMICAL SCIENCES

PP2A Regulates HDAC4 Nuclear Import

(2007) Gabriela Paroni et al.   MOLECULAR BIOLOGY OF THE CELL