Propargylic Se-adenosyl-l-selenomethionine: A Chemical Tool for Methylome Analysis

Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease

(2021) Kamakoti P. Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Properties of FDA-approved small molecule protein kinase inhibitors: a 2021 update

(2021) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

(2021) Erna Davydova et al.   Nature Communications

Enzyme-mediated bioorthogonal technologies: catalysts, chemoselective reactions and recent methyltransferase applications

(2021) Elnaz Jalali et al.   CURRENT OPINION IN BIOTECHNOLOGY

Tazemetostat: First Approval

(2020) Sheridan M. Hoy   DRUGS

Lysine methylation signaling of non-histone proteins in the nucleus

(2019) Dan Levy   CELLULAR AND MOLECULAR LIFE SCIENCES

Enzymatic or In Vivo Installation of Propargyl Groups in Combination with Click Chemistry for the Enrichment and Detection of Methyltransferase Target Sites in RNA

(2018) Katja Hartstock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical and Biochemical Perspectives of Protein Lysine Methylation

(2018) Minkui Luo   CHEMICAL REVIEWS

Methylation of Elongation Factor 1A: Where, Who, and Why?

(2018) Joshua J. Hamey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions

(2018) Tadahiro Shimazu et al.   Scientific Reports

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

(2018) Yoshihiro Sohtome et al.   CHEMICAL COMMUNICATIONS

Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT

(2018) Melinda M. Diver et al.   NATURE

Development of Chaetocin and S ‐Adenosylmethionine Analogues as Tools for Studying Protein Methylation

(2018) Yoshihiro Sohtome et al.   CHEMICAL RECORD

SETD3 is an actin histidine methyltransferase that prevents primary dystocia

(2018) Alex W. Wilkinson et al.   NATURE

Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8

(2018) Takeshi Tsusaka et al.   Epigenetics & Chromatin

SETD3 protein is the actin-specific histidine N-methyltransferase

(2018) Sebastian Kwiatkowski et al.   eLife

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation

(2017) Laure Ferry et al.   MOLECULAR CELL

SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases

(2015) Jing Zhang et al.   ACS Chemical Biology

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism

(2015) Taiho Kambe et al.   PHYSIOLOGICAL REVIEWS

Facile Chemoenzymatic Strategies for the Synthesis and Utilization ofS-Adenosyl-L-Methionine Analogues

(2014) Shanteri Singh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Emerging Technologies to Map the Protein Methylome

(2014) Scott M. Carlson et al.   JOURNAL OF MOLECULAR BIOLOGY

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Large-Scale, Protection-Free Synthesis of Se-Adenosyl-l-selenomethionine Analogues and Their Application as Cofactor Surrogates of Methyltransferases

(2014) Ian R. Bothwell et al.   ORGANIC LETTERS

Selenium-Based S-Adenosylmethionine Analog Reveals the Mammalian Seven-Beta-Strand Methyltransferase METTL10 to Be an EF1A1 Lysine Methyltransferase

(2014) Tadahiro Shimazu et al.   PLoS One

Enhanced Chemical Stability of AdoMet Analogues for Improved Methyltransferase-Directed Labeling of DNA

(2013) Gražvydas Lukinavičius et al.   ACS Chemical Biology

Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation

(2013) Magnus E. Jakobsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin

(2013) Fanny L. Cherblanc et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases

(2013) Fanny L Cherblanc et al.   Nature Chemical Biology

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity

(2013) Philippe Cloutier et al.   PLoS Genetics

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification

(2012) Shinya Fujishiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Selenium-Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild-Type Protein Methyltransferases

(2012) Sophie Willnow et al.   CHEMBIOCHEM

Se-Adenosyl-l-selenomethionine Cofactor Analogue as a Reporter of Protein Methylation

(2012) Ian R. Bothwell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases

(2012) Miglė Tomkuvienė et al.   NUCLEIC ACIDS RESEARCH

Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases

(2012) Timothy A. Couttas et al.   PROTEOMICS

H3K9 methyltransferase G9a and the related molecule GLP

(2011) Y. Shinkai et al.   GENES & DEVELOPMENT

Crystal structure of the human thioredoxin reductase–thioredoxin complex

(2011) Karin Fritz-Wolf et al.   Nature Communications

Enzymatic Site-Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling

(2010) Wibke Peters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae

(2010) Rebecca S. Lipson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Chemical Method for Labeling Lysine Methyltransferase Substrates

(2010) Olivier Binda et al.   CHEMBIOCHEM

Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity

(2010) Eriko Iwasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Anticancer Agent Chaetocin Is a Competitive Substrate and Inhibitor of Thioredoxin Reductase

(2008) Jennifer D. Tibodeau et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein lysine methyltransferase G9a acts on non-histone targets

(2008) Philipp Rathert et al.   Nature Chemical Biology