Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT

Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT

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Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms

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Protein prenylation: unique fats make their mark on biology

(2016) Mei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

(2016) Srisathiyanarayanan Dharmaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progeria: A Paradigm for Translational Medicine

(2014) Leslie B. Gordon et al.   CELL

Mutational Analysis of the Integral Membrane Methyltransferase Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Reveals Potential Substrate Binding Sites

(2014) Melinda M. Diver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

(2014) Xiaochun Li et al.   NATURE

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Proof of dual-topology architecture of Fluc F− channels with monobody blockers

(2014) Randy B. Stockbridge et al.   Nature Communications

Conservation and Functional Importance of Carbon–Oxygen Hydrogen Bonding in AdoMet-Dependent Methyltransferases

(2013) Scott Horowitz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains

(2013) F. Sha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria

(2013) M. X. Ibrahim et al.   SCIENCE

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

(2011) Akiko Koide et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase ICMT

(2011) Jing Yang et al.   MOLECULAR CELL

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Functional Oligomerization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxyl Methyltransferase, Ste14p

(2010) Amy M. Griggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Engineering of recombinant crystallization chaperones

(2009) Shohei Koide   CURRENT OPINION IN STRUCTURAL BIOLOGY

Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe

(2009) L. P. Wright et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols

Accelerating phage-display library selection by reversible and site-specific biotinylation

(2009) A. Koide et al.   PROTEIN ENGINEERING DESIGN & SELECTION