Development of Chaetocin and S ‐Adenosylmethionine Analogues as Tools for Studying Protein Methylation

Chemical and Biochemical Perspectives of Protein Lysine Methylation

(2018) Minkui Luo   CHEMICAL REVIEWS

Methylation of Elongation Factor 1A: Where, Who, and Why?

(2018) Joshua J. Hamey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions

(2018) Tadahiro Shimazu et al.   Scientific Reports

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

(2018) Yoshihiro Sohtome et al.   CHEMICAL COMMUNICATIONS

Reversibility of 3-Phenyl-2-oxindole Dimer Formation: Application to Construct Compounds with Two Distinct Vicinal All-Carbon Quaternary Centers

(2017) Mikiko Sodeoka et al.   HETEROCYCLES

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

(2017) Frank Lyko   NATURE REVIEWS GENETICS

Protein lysine methylation by seven- -strand methyltransferases

(2016) P. O. Falnes et al.   BIOCHEMICAL JOURNAL

Chemical genetics approaches for selective intervention in epigenetics

(2016) Andrew C Runcie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription

(2016) Yasushi Takemoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus

(2016) S. Snigdha et al.   JOURNAL OF NEUROSCIENCE

Determining the Mitochondrial Methyl Proteome in Saccharomyces cerevisiae using Heavy Methyl SILAC

(2016) Katelyn E. Caslavka Zempel et al.   JOURNAL OF PROTEOME RESEARCH

Chemical Proteomic Profiling of Human Methyltransferases

(2016) Benjamin D. Horning et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target identification with quantitative activity based protein profiling (ABPP)

(2016) Xiao Chen et al.   PROTEOMICS

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids

(2015) Justin Kim et al.   ACCOUNTS OF CHEMICAL RESEARCH

SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases

(2015) Jing Zhang et al.   ACS Chemical Biology

Protein Methyltransferases: A Distinct, Diverse, and Dynamic Family of Enzymes

(2015) P. Ann Boriack-Sjodin et al.   BIOCHEMISTRY

Open access chemical probes for epigenetic targets

(2015) Peter J Brown et al.   Future Medicinal Chemistry

Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis

(2015) Rong Long et al.   NATURAL PRODUCT REPORTS

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy

(2015) Jun Ando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tricyclic analogues of epidithiodioxopiperazine alkaloids with promising in vitro and in vivo antitumor activity

(2015) Marcus Baumann et al.   Chemical Science

Chemical Probes of Histone Lysine Methyltransferases

(2014) H. Ümit Kaniskan et al.   ACS Chemical Biology

Using S-adenosyl-l-homocysteine capture compounds to characterize S-adenosyl-l-methionine and S-adenosyl-l-homocysteine binding proteins

(2014) Lindsey J. Brown et al.   ANALYTICAL BIOCHEMISTRY

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Emerging Roles of RNA Modification: m 6 A and U-Tail

(2014) Mihye Lee et al.   CELL

Small Molecule Control of Chromatin Remodeling

(2014) Aidan Finley et al.   CHEMISTRY & BIOLOGY

A “Catch-and-Release” Protocol for Alkyne-Tagged Molecules Based on a Resin-Bound Cobalt Complex for Peptide Enrichment in Aqueous Media

(2014) Ayako Miyazaki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation

(2014) Tobias Wagner et al.   ChemMedChem

Selective Inhibitors of Protein Methyltransferases

(2014) H. Ümit Kaniskan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging Technologies to Map the Protein Methylome

(2014) Scott M. Carlson et al.   JOURNAL OF MOLECULAR BIOLOGY

Epidithiodioxopiperazines. occurrence, synthesis and biogenesis

(2014) Timothy R. Welch et al.   NATURAL PRODUCT REPORTS

Non-histone protein methylation as a regulator of cellular signalling and function

(2014) Kyle K. Biggar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Large-Scale, Protection-Free Synthesis of Se-Adenosyl-l-selenomethionine Analogues and Their Application as Cofactor Surrogates of Methyltransferases

(2014) Ian R. Bothwell et al.   ORGANIC LETTERS

Selenium-Based S-Adenosylmethionine Analog Reveals the Mammalian Seven-Beta-Strand Methyltransferase METTL10 to Be an EF1A1 Lysine Methyltransferase

(2014) Tadahiro Shimazu et al.   PLoS One

Structural biology and chemistry of protein arginine methyltransferases

(2014) Matthieu Schapira et al.   MedChemComm

Profiling Substrates of Protein Arginine N-Methyltransferase 3 with S-Adenosyl-l-methionine Analogues

(2013) Han Guo et al.   ACS Chemical Biology

Enhanced Chemical Stability of AdoMet Analogues for Improved Methyltransferase-Directed Labeling of DNA

(2013) Gražvydas Lukinavičius et al.   ACS Chemical Biology

A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells

(2013) Rui Wang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation

(2013) Magnus E. Jakobsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin

(2013) Fanny L. Cherblanc et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases

(2013) Fanny L Cherblanc et al.   Nature Chemical Biology

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Raman and SERS microscopy for molecular imaging of live cells

(2013) Almar F Palonpon et al.   Nature Protocols

Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation

(2013) K. Islam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SET for life: biochemical activities and biological functions of SET domain-containing proteins

(2013) Hans-Martin Herz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein methylation at the surface and buried deep: thinking outside the histone box

(2013) Steven G. Clarke   TRENDS IN BIOCHEMICAL SCIENCES

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity

(2013) Philippe Cloutier et al.   PLoS Genetics

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification

(2012) Shinya Fujishiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications

(2012) Anna-Winona Struck et al.   CHEMBIOCHEM

A Selenium-Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild-Type Protein Methyltransferases

(2012) Sophie Willnow et al.   CHEMBIOCHEM

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

(2012) Masanari Takahashi et al.   JOURNAL OF ANTIBIOTICS

Bioorthogonal Profiling of Protein Methylation Using Azido Derivative of S-Adenosyl-l-methionine

(2012) Kabirul Islam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Se-Adenosyl-l-selenomethionine Cofactor Analogue as a Reporter of Protein Methylation

(2012) Ian R. Bothwell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells

(2012) Hiroyuki Yamakoshi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases

(2012) Timothy A. Couttas et al.   PROTEOMICS

Expanding Cofactor Repertoire of Protein Lysine Methyltransferase for Substrate Labeling

(2011) Kabirul Islam et al.   ACS Chemical Biology

Structure, Bioactivity and Synthesis of Natural Products with Hexahydropyrrolo[2,3-b]indole

(2011) Pau Ruiz-Sanchis et al.   CHEMISTRY-A EUROPEAN JOURNAL

H3K9 methyltransferase G9a and the related molecule GLP

(2011) Y. Shinkai et al.   GENES & DEVELOPMENT

Epipolythiodiketopiperazine Alkaloids: Total Syntheses and Biological Activities

(2011) Eriko Iwasa  et al.   ISRAEL JOURNAL OF CHEMISTRY

Labeling Substrates of Protein Arginine Methyltransferase with Engineered Enzymes and MatchedS-Adenosyl-l-methionine Analogues

(2011) Rui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy

(2011) Hiroyuki Yamakoshi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors

(2011) Rui Wang et al.   Molecular BioSystems

Total syntheses of chaetocin and ent-chaetocin

(2011) Eriko Iwasa et al.   TETRAHEDRON

Enzymatic Site-Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling

(2010) Wibke Peters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae

(2010) Rebecca S. Lipson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation

(2010) Yuou Teng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Chemical Method for Labeling Lysine Methyltransferase Substrates

(2010) Olivier Binda et al.   CHEMBIOCHEM

Synthesis of S-Adenosyl-L-homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases

(2010) Christian Dalhoff et al.   CHEMBIOCHEM

General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A

(2010) Justin Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity

(2010) Eriko Iwasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Uncovering the Human Methyltransferasome

(2010) Tanya C. Petrossian et al.   MOLECULAR & CELLULAR PROTEOMICS

Grand Challenge Commentary: RNA epigenetics?

(2010) Chuan He   Nature Chemical Biology

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Total Synthesis of (+)-11,11'-Dideoxyverticillin A

(2009) J. Kim et al.   SCIENCE