Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

(2015) Mitchell L. Leibowitz et al.   Annual Review of Genetics

New approaches for improving outcomes in breast cancer in Europe

(2015) Angelo Di Leo et al.   BREAST

Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: ‘What does not kill me strengthens me’

(2015) A O Pisco et al.   BRITISH JOURNAL OF CANCER

Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide

(2015) Anda Huna et al.   CELL CYCLE

DNA ploidy and morphology of colon tumors in the adenoma–carcinoma sequence

(2015) Judith Staarmann et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Aneuploidy and chromosomal instability in cancer: a jackpot to chaos

(2015) Maybelline Giam et al.   Cell Division

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

(2015) C Leikam et al.   Cell Death & Disease

The requirement of p53 for maintaining chromosomal stability during tetraploidization

(2015)   Oncotarget

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer

(2015) Rebecca Lamb et al.   Oncotarget

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

(2014) Zhanna V Chitikova et al.   CELL CYCLE

Multiparameter DNA content analysis identifies distinct groups in primary breast cancer

(2013) J H S Dayal et al.   BRITISH JOURNAL OF CANCER

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

(2013) Jekaterina Erenpreisa et al.   Cancer Cell International

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

(2013) Thomas R. Jackson et al.   CELL CYCLE

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer

(2013) A R Palla et al.   ONCOGENE

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression

(2012) Li Zheng et al.   Nature Communications

Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells

(2011) Michael Y. Sherman et al.   AGING CELL

Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation

(2011) Jekaterina Erenpreisa et al.   CELL BIOLOGY INTERNATIONAL

Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer

(2011) Yoshimi Arima et al.   INTERNATIONAL JOURNAL OF CANCER

Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

(2011) Santhi Achuthan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The aneuploidy paradox: costs and benefits of an incorrect karyotype

(2011) Jason M. Sheltzer et al.   TRENDS IN GENETICS

Gender and ploidy in cancer survival

(2011) Susanne Schulze et al.   CELLULAR ONCOLOGY

Polyploidy: The Link Between Senescence and Cancer

(2010) G. Mosieniak et al.   CURRENT PHARMACEUTICAL DESIGN

Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells

(2010) Kristine Salmina et al.   EXPERIMENTAL CELL RESEARCH

Allele-specific copy number analysis of tumors

(2010) P. Van Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal instability determines taxane response

(2009) C. Swanton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS