Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19

Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target

(2021) Alina Renz  et al.   Genes

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

MEMOTE for standardized genome-scale metabolic model testing

(2020) Christian Lieven et al.   NATURE BIOTECHNOLOGY

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

(2020) Livan Delgado-Roche et al.   ARCHIVES OF MEDICAL RESEARCH

Cluster of coronavirus disease 2019 (Covid-19) in the French Alps, 2020

(2020) Kostas Danis et al.   CLINICAL INFECTIOUS DISEASES

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

(2020) Christian A. Devaux et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target

(2020) Mohamed Abu-Farha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)

(2020) Ruiyun Li et al.   SCIENCE

Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?

(2020) Tuğçenur Uzun et al.   Chinese Medicine

Vitamin-D and COVID-19: do deficient risk a poorer outcome?

(2020) Fiona Mitchell   Lancet Diabetes & Endocrinology

COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms

(2020) Marek Ostaszewski et al.   Scientific Data

COVID-19: Immunology and treatment options

(2020) Susanna Felsenstein et al.   CLINICAL IMMUNOLOGY

SBML Level 3: an extensible format for the exchange and reuse of biological models

(2020) Sarah M Keating et al.   Molecular Systems Biology

Community standards to facilitate development and address challenges in metabolic modeling

(2020) Maureen A Carey et al.   Molecular Systems Biology

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract

(2020) Yichuan Liu et al.   Viruses-Basel

Covid-19: Remdesivir has little or no impact on survival, WHO trial shows

(2020) Owen Dyer   BMJ-British Medical Journal

FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2

(2020) Alina Renz et al.   BIOINFORMATICS

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

BioModels—15 years of sharing computational models in life science

(2019) Rahuman S Malik-Sheriff et al.   NUCLEIC ACIDS RESEARCH

BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree

(2019) Charles J Norsigian et al.   NUCLEIC ACIDS RESEARCH

Recon3D enables a three-dimensional view of gene variation in human metabolism

(2018) Elizabeth Brunk et al.   NATURE BIOTECHNOLOGY

Integrated human-virus metabolic stoichiometric modelling predicts host-based antiviral targets against Chikungunya, Dengue and Zika viruses

(2018) Sean Aller et al.   Journal of the Royal Society Interface

Inhibition of cytosolic phospholipase A2α impairs an early step of coronavirus replication in cell culture

(2017) Christin Müller et al.   JOURNAL OF VIROLOGY

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Pathway collages: personalized multi-pathway diagrams

(2016) Suzanne Paley et al.   BMC BIOINFORMATICS

ChEBI in 2016: Improved services and an expanding collection of metabolites

(2015) Janna Hastings et al.   NUCLEIC ACIDS RESEARCH

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

(2014) Adriaan H. de Wilde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking

(2013) Julie Blaising et al.   ANTIVIRAL RESEARCH

COBRApy: COnstraints-Based Reconstruction and Analysis for Python

(2013) Ali Ebrahim et al.   BMC Systems Biology

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases

(2013) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE

(2012) Yuliang Wang et al.   BMC Systems Biology

Beyond the genome (BTG) is a (PGDB) pathway genome database: HumanCyc

(2012) Miles Trupp et al.   GENOME BIOLOGY

Identifiers.org and MIRIAM Registry: community resources to provide persistent identification

(2011) N. Juty et al.   NUCLEIC ACIDS RESEARCH

Multifaceted roles for lipids in viral infection

(2011) Nicholas S. Heaton et al.   TRENDS IN MICROBIOLOGY

Update on the use of melatonin in pediatrics

(2010) Eloisa Gitto et al.   JOURNAL OF PINEAL RESEARCH

Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions

(2010) Aarash Bordbar et al.   Molecular Systems Biology

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

Combination therapy of statins and fibrates in the management of cardiovascular risk

(2009) Catherine Fiévet et al.   CURRENT OPINION IN LIPIDOLOGY

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH