Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents

Sphingosine kills bacteria by binding to cardiolipin

(2020) Rabea Verhaegh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloroquine fumardiamides as novel quorum sensing inhibitors

(2020) Maja Beus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Screening of FDA-Approved Drugs Using a 384-Well Plate-Based Biofilm Platform: The Case of Fingolimod

(2020) Shella Gilbert-Girard et al.   Microorganisms

Drug Repurposing for the Treatment of Bacterial and Fungal Infections

(2019) Andrea Miró-Canturri et al.   Frontiers in Microbiology

Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia

(2019) Aaron P. Seitz et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Exploring physicochemical space via a bioisostere of the trifluoromethyl and ethyl groups (BITE): attenuating lipophilicity in fluorinated analogues of Gilenya® for multiple sclerosis

(2018) Nathalie Erdeljac et al.   CHEMICAL COMMUNICATIONS

Synthesis and Biological Evaluation of FTY720 (Fingolimod) Derivatives with Aromatic Head Group as Anticancer Agents

(2018) Taeho Lee et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation

(2018) Jitendra Shrestha et al.   MOLECULES

Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA

(2017) Carlos A Puyo et al.   Molecular Pain

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens

(2017) Kareem R. Rumah et al.   Frontiers in Cellular and Infection Microbiology

Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria

(2017) Jérôme Becam et al.   Scientific Reports

Pseudomonas aeruginosa ATCC 9027 is a non-virulent strain suitable for mono-rhamnolipids production

(2016) María-Victoria Grosso-Becerra et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis

(2016) Shaghayegh Tavakoli Tabazavareh et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Flavones as Quorum Sensing Inhibitors Identified by a Newly Optimized Screening Platform Using Chromobacterium violaceum as Reporter Bacteria

(2016) Malena Skogman et al.   MOLECULES

The emerging role of FTY720 (Fingolimod) in cancer treatment

(2016) Christopher White et al.   Oncotarget

Draft genome sequence of Acinetobacter baumannii strain NCTC 13423, a multidrug-resistant clinical isolate

(2016) Joran E. Michiels et al.   Standards in Genomic Sciences

Antimicrobial resistance: A global emerging threat to public health systems

(2015) Maurizio Ferri et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Anti-adherence and bactericidal activity of sphingolipids againstStreptococcus mutans

(2015) Nivedita Cukkemane et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod

(2015) Sathya Narayanan Patmanathan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synthesis and Evaluation of Fluorinated Fingolimod (FTY720) Analogues for Sphingosine-1-Phosphate Receptor Molecular Imaging by Positron Emission Tomography

(2015) Rizwan S. Shaikh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence

(2015) Venkadesaperumal Gopu et al.   PLoS One

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa

(2014) Y. Pewzner-Jung et al.   EMBO Molecular Medicine

Novel approaches for the design and discovery of quorum-sensing inhibitors

(2014) Sara Scutera et al.   Expert Opinion on Drug Discovery

Innate Immunity Mediating Inflammation Secondary to Endotracheal Intubation

(2013) Carlos A. Puyo et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Suzuki coupling based synthesis and in vitro cytotoxic evaluation of Fingolimod and analogues

(2013) Tie-Wen Mei et al.   TETRAHEDRON

Practical synthesis of fingolimod from diethyl acetamidomalonate

(2013) Bhaskar Kandagatla et al.   RSC Advances

Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials

(2012) Carla Renata Arciola et al.   BIOMATERIALS

Pathogenesis and treatment concepts of orthopaedic biofilm infections

(2012) Werner Zimmerli et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms

(2012) Malena Elise Skogman et al.   JOURNAL OF ANTIBIOTICS

Antibacterial Activity of Sphingoid Bases and Fatty Acids against Gram-Positive and Gram-Negative Bacteria

(2011) Carol L. Fischer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Non-phosphorylated FTY720 Induces Apoptosis of Human Microglia by Activating SREBP2

(2011) Takashi Yoshino et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Phosphorylation of the Immunomodulator FTY720 Inhibits Programmed Cell Death of Fibroblasts Via the S1P3 Receptor Subtype and Bcl-2 Activation

(2010) Henrik Potteck et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1Agonists with Reduced Effect on Heart Rate

(2010) Maiko Hamada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient chromatography-free synthesis of the oxy-analogue of fingolimod

(2010) Aleksandra Zivkovic et al.   TETRAHEDRON LETTERS

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES