Non-phosphorylated FTY720 Induces Apoptosis of Human Microglia by Activating SREBP2

Molecular Network Analysis Suggests Aberrant CREB-Mediated Gene Regulation in the Alzheimer Disease Hippocampus

(2013) Jun-ichi Satoh et al.   DISEASE MARKERS

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

(2010) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Fingolimod provides long-term protection in rodent models of cerebral ischemia

(2010) Ying Wei et al.   ANNALS OF NEUROLOGY

Sterol metabolism and SREBP activation

(2010) Ryuichiro Sato   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phosphorylation of the Immunomodulator FTY720 Inhibits Programmed Cell Death of Fibroblasts Via the S1P3 Receptor Subtype and Bcl-2 Activation

(2010) Henrik Potteck et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function

(2010) Joanna M. Woodcock et al.   CELLULAR SIGNALLING

FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages

(2010) Tomas Blom et al.   CIRCULATION RESEARCH

FTY720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D1 and Phospho-Akt in Mantle Cell Lymphoma

(2010) Q. Liu et al.   CLINICAL CANCER RESEARCH

CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis

(2010) Y. Jin et al.   DRUG METABOLISM AND DISPOSITION

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720

(2010) Yu Hisano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential responses of human microglia and blood-derived myeloid cells to FTY720

(2010) Bryce A. Durafourt et al.   JOURNAL OF NEUROIMMUNOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Human Microglia Transplanted in Rat Focal Ischemia Brain Induce Neuroprotection and Behavioral Improvement

(2010) Dashdemberel Narantuya et al.   PLoS One

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

(2010) Hongbo Chi   TRENDS IN PHARMACOLOGICAL SCIENCES

Human caspase 7 is positively controlled by SREBP-1 and SREBP-2

(2009) Laure Gibot et al.   BIOCHEMICAL JOURNAL

Down-regulation of S1P1Receptor Surface Expression by Protein Kinase C Inhibition

(2009) Sven-Christian Sensken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod) on Antiproliferative Activity against Breast and Colon Cancer Cells

(2008) Yasuo Nagaoka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

(2007) Kumlesh K. Dev et al.   PHARMACOLOGY & THERAPEUTICS