An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues

A Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential

(2020) Jessica A Palmer et al.   TOXICOLOGICAL SCIENCES

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

(2020) Zhiqiang Pang et al.   Metabolites

Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions

(2020) Boris Sarvin et al.   Nature Communications

struct: an R/Bioconductor-based framework for standardized metabolomics data analysis and beyond

(2020) Gavin Rhys Lloyd et al.   BIOINFORMATICS

Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography–Mass Spectrometry Clinical Metabolic Phenotyping Assays

(2020) Andrew D. Southam et al.   JOURNAL OF PROTEOME RESEARCH

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

(2019) Mark R. Viant et al.   Nature Communications

In vitro assessment of hepatotoxicity by metabolomics: a review

(2018) Matthias Cuykx et al.   ARCHIVES OF TOXICOLOGY

Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology

(2018) Caroline R. Archer et al.   Scientific Reports

Today’s Challenges to De-Risk and Predict Drug Safety in Human “Mind-the-Gap”

(2018) Richard J Weaver et al.   TOXICOLOGICAL SCIENCES

A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics

(2017) Andrew D Southam et al.   Nature Protocols

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

(2017) Erica K. Brockmeier et al.   TOXICOLOGICAL SCIENCES

Metabolic Profiling of healthy and cancerous tissues in 2D and 3D

(2017) Shonagh Russell et al.   Scientific Reports

Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

(2016) Igho J. Onakpoya et al.   BMC Medicine

Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells

(2016) Zhi-Quan Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolomics: beyond biomarkers and towards mechanisms

(2016) Caroline H. Johnson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery

(2016) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis

(2016) J. Travis Hinson et al.   Cell Reports

Fast Filtration of Bacterial or Mammalian Suspension Cell Cultures for Optimal Metabolomics Results

(2016) Natalie Bordag et al.   PLoS One

Cardiotoxicity screening: a review of rapid-throughput in vitro approaches

(2015) Xichun Li et al.   ARCHIVES OF TOXICOLOGY

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

(2015) Umesh Chaudhari et al.   ARCHIVES OF TOXICOLOGY

Screening, Verification, and Optimization of Biomarkers for Early Prediction of Cardiotoxicity Based on Metabolomics

(2015) Yubo Li et al.   JOURNAL OF PROTEOME RESEARCH

Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types

(2015) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Importance of Toxicokinetics for Interspecies Variation in Sensitivity to Chemicals

(2014) Anna-Maija Nyman et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2014) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Metabolomics in toxicology and preclinical research

(2014) Tzutzuy Ramirez   ALTEX-Alternatives to Animal Experimentation

Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow

(2013) J. A. Kirwan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Review: Toxicometabolomics

(2013) Mounir Bouhifd et al.   JOURNAL OF APPLIED TOXICOLOGY

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

(2013) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

2D and 3D-Organized Cardiac Cells Shows Differences in Cellular Morphology, Adhesion Junctions, Presence of Myofibrils and Protein Expression

(2012) Carolina Pontes Soares et al.   PLoS One

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

(2010) CE Pollard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics

(2009) Jiangshan Wang et al.   Metabolomics

Spectral relative standard deviation: a practical benchmark in metabolomics

(2008) Helen M. Parsons et al.   ANALYST