Article
Pharmacology & Pharmacy
Stein Schalkwijk, Tarjinder Sahota, Remy B. Verheijen, Alexander R. Harmer, Ghada F. Ahmed
Summary: This passage discusses the study on the effect of Savolitinib on the QT interval in healthy subjects, with analysis conducted through exposure-response modeling. The results indicate the contribution of the M2 metabolite to QTc prolongation, and simulation studies demonstrate the impact of Savolitinib on electrocardiograms at different doses.
Article
Chemistry, Medicinal
Hiroki Morishita, Liyanage Manosika Buddhini Perera, Xieyi Zhang, Kenta Mizoi, Masa-aki Ito, Kentaro Yano, Takuo Ogihara
Summary: The combined use of Pimozide with other drugs may increase the risk of cardiac arrest. This study investigated the accumulation of Pimozide in cardiomyocytes and its inhibitory effect on cardiac channels, showing that Pimozide accumulation is influenced by other drugs, leading to an increased risk of channel inhibition.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Neurosciences
Constance Bordet, Philippe Garcia, Francesco Salvo, Anthony Touafchia, Michel Galinier, Agnes Sommet, Francois Montastruc
Summary: This study investigates the risk of QT prolongation reporting among different antipsychotics using real-world data. The results suggest that sertindole and ziprasidone are associated with the highest risk of QT prolongation reporting. Additionally, antipsychotics with higher hERG affinity are more likely to be associated with QT prolongations reports.
PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Erika N. Titus-Lay, Heather A. Jaynes, Elena Tomaselli Muensterman, Carol A. Ott, Todd A. Walroth, Gabriela Williams, Paul R. Moe, Michelle Wilbrandt, James E. Tisdale
Summary: The study aimed to assess the accuracy of a handheld smartphone ECG for QT measurement in patients on maintenance methadone therapy, showing that the iECG is accurate and moderately good for identifying patients with methadone-associated QTc prolongation.
Article
Critical Care Medicine
Roi Bar Cohen, Matthew Dai, Anthony Aizer, Chirag Barbhaiya, Connor Peterson, Scott Bernstein, David S. Park, Michael Spinelli, Larry A. Chinitz, Lior Jankelson
Summary: The QTc/JTc interval is significantly and independently prolonged after sudden cardiac arrest, regardless of known QT prolonging triggers. Normalization of the QTc is expected only after day 6 of hospitalization. Assessment of the QTc for determining the etiology of arrest or monitoring the effect of QT prolonging medications may be unreliable.
Article
Pharmacology & Pharmacy
Wendy W. Wu, Moran Choe, Lars Johannesen, Jose Vicente, Girish Bende, Norman L. Stockbridge, David G. Strauss, Christine Garnett
Summary: The study found that hERG and ventricular repolarization assays cannot predict clinical QT(C) prolongation potential for peptides and proteins. Peptides and proteins, regardless of size, have a low likelihood of direct cardiac ion channel interactions, similar to large targeted proteins and monoclonal antibodies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Zheng Zequn, Wu Yujia, Qian Dingding, Lian Jiangfang
Summary: COVID-19, caused by SARS-CoV2, poses challenges to the medical system due to lack of safe and effective treatment methods; some old drugs may cause cardiotoxicity by blocking hERG channels; understanding drug interactions with hERG channels is crucial for developing safer and more effective drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Chien-Hsien Lo, Yu-Hsun Wang, Chin-Feng Tsai, Kuei-Chuan Chan, Li-Ching Li, Tse-Hsien Lo, James Cheng-Chung Wei, Chun-Hung Su
Summary: In patients with systemic lupus erythematosus, hydroxychloroquine treatment did not significantly increase the risk of cardiac arrhythmia or life-threatening ventricular arrhythmia regardless of the different hydroxychloroquine treatment duration, drug adherence rate, or daily dose.
Review
Medicine, General & Internal
Rani Khatib, Fatima R. N. Sabir, Caroline Omari, Chris Pepper, Muzahir Hassan Tayebjee
Summary: Many drug therapies can prolong the QT interval and increase the risk of Torsades de Pointes. Consideration of patient-related risk factors, the potential risk of QT prolongation with a drug, and co-prescribed medicines that may increase the risk are crucial when prescribing drugs associated with QT prolongation.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Editorial Material
Pharmacology & Pharmacy
Zachary R. Noel, Vincent Y. See, Alexander H. Flannery
Summary: Acute care pharmacists play a crucial role in identifying drug-drug interactions that may lead to QT prolongation, but there is a risk of overemphasis on the QTc interval in some cases.
ANNALS OF PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Shihai Li, Zili Xu, Mingkun Guo, Menglong Li, Zhining Wen
Summary: Drug-induced prolongation of the QT interval is a common issue that hinders the understanding of its mechanism and the development of effective prediction strategies. To address this, a new model called DIQTA is proposed to stratify the risk of drug-induced QT interval prolongation. Potential applications of DIQTA include precision dosing in off-label use and therapeutic strategy optimization, as well as facilitating the development of predictive toxicity models based on artificial intelligence.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Wulin Long, Shihai Li, Yujie He, Jinzhu Lin, Menglong Li, Zhining Wen
Summary: In this study, the differences in chemical structures between QT-prolonging drugs and drugs with no drug-induced QT prolongation concerns were investigated. Three categories of structural alerts (SAs) were found to be closely associated with the risk of drug-induced QT prolongation. A structure-activity relationship (SAR) model based on molecular descriptors associated with these SAs was developed to predict the high risk of inducing QT interval prolongation of marketed drugs. These findings contribute to a better understanding of the mechanism of drug-induced QT prolongation and facilitate research on cardiac adverse drug reactions in drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Benny M. Amore, Clay T. Cramer, Diane E. MacDougall, William J. Sasiela, Maurice G. Emery
Summary: Bempedoic acid, an approved inhibitor for hypercholesterolemia, was found to have weak binding potency to the hERG potassium channel and did not cause QTc prolongation in healthy subjects, as shown in both in vitro and animal studies.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Oncology
Jian Zhang, Dongmei Ji, Weina Shen, Qin Xiao, Yajia Gu, Joyce 'Shaughnessy, Xichun Hu
Summary: The novel antibody-drug conjugate ARX788, comprised of an anti-HER2 mAb and a potent tubulin inhibitor payload AS269, shows a manageable safety profile and promising preliminary signs of activity in patients with HER2-positive MBC who progressed on prior anti-HER2 therapies.
CLINICAL CANCER RESEARCH
(2022)
Review
Emergency Medicine
Lauren B. Robison, William J. Brady, Robert A. Robison, Nathan Charlton
Summary: Prolongation of the QTc interval is associated with an increased risk of malignant ventricular dysrhythmias and sudden cardiac death. However, specific quantifiable risk rates in relation to specific QTc interval length remain unknown. Current literature is inadequate to provide a definitive answer, requiring further prospective research on this topic.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)