Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages

(2021) Liang Dong et al.   MOLECULAR IMMUNOLOGY

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

(2020) Shuai Ma et al.   CELL

Physical Activity and Diet Shape the Immune System during Aging

(2020) Christopher Weyh et al.   Nutrients

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

(2020) Bo Pan et al.   CIRCULATION RESEARCH

Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells

(2020) Md. Razaul Karim et al.   PLoS One

Novel Proteasome Assembly Chaperone mutations in PSMG2/PAC2, cause the autoinflammatory interferonopathy, CANDLE/PRAAS4

(2019) Adriana A. de Jesus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunoproteasome activation enables human TRIM5α restriction of HIV-1

(2019) Jose M. Jimenez-Guardeño et al.   Nature Microbiology

PSMB10, the last immunoproteasome gene missing for PRAAS

(2019) Guillaume Sarrabay et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome

(2018) M. Cecilia Poli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice

(2018) H. Wolfe et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

(2018) Denisse Sepulveda et al.   MOLECULAR CELL

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Aging Hallmarks: The Benefits of Physical Exercise

(2018) Alexandre Rebelo-Marques et al.   Frontiers in Endocrinology

Origin of the Autophagosome Membrane in Mammals

(2018) Yun Wei et al.   Biomed Research International

Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones

(2018) Matthias P Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy

(2018) Alberto Danieli et al.   JOURNAL OF CELL SCIENCE

Caloric restriction and cellular senescence

(2018) Luigi Fontana et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

(2018) Rahul S. Samant et al.   NATURE

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

(2017) Xiaorong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Activity, Sedentary Behavior, and Inflammatory and Hemostatic Markers in Men

(2017) TESSA J. PARSONS et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Epigenetic Control of Autophagy: Nuclear Events Gain More Attention

(2017) Sung Hee Baek et al.   MOLECULAR CELL

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

(2017) Philip Kranz et al.   Cell Death & Disease

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

(2017) Aslihan Ugun-Klusek et al.   Cell Death & Disease

The role of the immunoproteasome in interferon-γ-mediated microglial activation

(2017) Kasey E. Moritz et al.   Scientific Reports

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

(2017) Elisabeth Stürner et al.   Frontiers in Molecular Neuroscience

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

(2017) Filippo Scialò et al.   Frontiers in Physiology

Redox regulation of proteasome function

(2017) Maria Lefaki et al.   Redox Biology

Proteostasis, oxidative stress and aging

(2017) Ioanna Korovila et al.   Redox Biology

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice

(2017) Lisa K. Wagner et al.   Acta Neuropathologica Communications

Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation

(2017) Cristina Pintado et al.   Scientific Reports

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

(2016) Amiya Kumar Ghosh et al.   Aging-US

Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure

(2016) Yohan Santin et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in sepsis: Degradation into exhaustion?

(2016) Jeffery Ho et al.   Autophagy

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The fine-tuning of proteolytic pathways in Alzheimer’s disease

(2016) Valentina Cecarini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aging is associated with hypermethylation of autophagy genes in macrophages

(2016) Hany Khalil et al.   Epigenetics

Interactions between Autophagy and Inhibitory Cytokines

(2016) Tian-tian Wu et al.   International Journal of Biological Sciences

KIAA0368-deficiency affects disassembly of 26S proteasome under oxidative stress condition

(2016) Kousuke Haratake et al.   JOURNAL OF BIOCHEMISTRY

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways

(2016) Rachel Raynes et al.   MOLECULAR ASPECTS OF MEDICINE

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts

(2016) Christiane Ott et al.   Redox Biology

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

(2015) Jaime L. Schneider et al.   AGING CELL

Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity

(2015) Paola Lucia Minciullo et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells

(2015) Yan-Ning Rui et al.   Autophagy

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Spliced XBP1 promotes macrophage survival and autophagy by interacting with Beclin-1

(2015) Ping-Ge Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats

(2015) Rachel B. Scheinert et al.   BRAIN BEHAVIOR AND IMMUNITY

Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase

(2015) Shaoning Jiang et al.   CELLULAR SIGNALLING

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Membrane dynamics in autophagosome biogenesis

(2015) S. R. Carlsson et al.   JOURNAL OF CELL SCIENCE

Heat shock protein responses to aging and proteotoxicity in the olfactory bulb

(2015) Tyler S. Crum et al.   JOURNAL OF NEUROCHEMISTRY

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

(2015) Shengyi Sun et al.   NATURE CELL BIOLOGY

Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress

(2015) Elena Gavilán et al.   NEUROBIOLOGY OF AGING

The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons

(2015) Maxim Salganik et al.   NEUROBIOLOGY OF AGING

Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

Dysfunction in protein clearance by the proteasome: impact on autoinflammatory diseases

(2015) Anja Brehm et al.   Seminars in Immunopathology

Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism

(2015) Elena Gavilán et al.   Scientific Reports

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells

(2014) Han Min et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway

(2014) Shun Kageyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6  Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

(2014) A. Higa et al.   MOLECULAR AND CELLULAR BIOLOGY

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

(2014) A. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible 26S Proteasome Disassembly upon Mitochondrial Stress

(2014) Nurit Livnat-Levanon et al.   Cell Reports

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Balance between autophagic pathways preserves retinal homeostasis

(2013) Natalia Rodríguez-Muela et al.   AGING CELL

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

Forming disulfides in the endoplasmic reticulum

(2013) Ojore B.V. Oka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Orchestration of secretory protein folding by ER chaperones

(2013) Tali Gidalevitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Selective Autophagy: Talking with the UPS

(2013) Caroline Park et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy

(2013) Shuxian Dong et al.   Cell Metabolism

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

(2013) Li Luo et al.   EXPERIMENTAL GERONTOLOGY

Autophagic response to exercise training in skeletal muscle with age

(2013) Yong An Kim et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Epigenetic Regulation of Autophagy by the Methyltransferase G9a

(2013) A. Artal-Martinez de Narvajas et al.   MOLECULAR AND CELLULAR BIOLOGY

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

The return of the nucleus: transcriptional and epigenetic control of autophagy

(2013) Jens Füllgrabe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Knockdown of PSMB7 Induces Autophagy in Cardiomyocyte Cultures: Possible Role in Endoplasmic Reticulum Stress

(2013) Victoria O. Kyrychenko et al.   PATHOBIOLOGY

Poly-Ub-Substrate-Degradative Activity of 26S Proteasome Is Not Impaired in the Aging Rat Brain

(2013) Carolin Giannini et al.   PLoS One

Protein Folding in the Endoplasmic Reticulum

(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome

(2012) Shona H. Wood et al.   AGE

Redox Control of 20S Proteasome Gating

(2012) Gustavo M. Silva et al.   ANTIOXIDANTS & REDOX SIGNALING

Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β

(2012) Cheol-Hee Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells

(2012) Denis Selimovic et al.   CELLULAR SIGNALLING

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-related differences in the dynamics of hippocampal proteasome recovery

(2012) M. Paz Gavilán et al.   JOURNAL OF NEUROCHEMISTRY

Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus

(2012) Cristina Pintado et al.   Journal of Neuroinflammation

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B

(2012) Connie W. Woo et al.   NATURE CELL BIOLOGY

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Chaperones in autophagy

(2012) Susmita Kaushik et al.   PHARMACOLOGICAL RESEARCH

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts

(2012) Alison M Connor et al.   ARTHRITIS RESEARCH & THERAPY

Disulfide Bond Formation in the Mammalian Endoplasmic Reticulum

(2012) N. J. Bulleid   Cold Spring Harbor Perspectives in Biology

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity

(2011) Yin Liu et al.   ARTHRITIS AND RHEUMATISM

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress

(2011) Tilman Grune et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

(2011) Akiko Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

(2011) K. Arima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

(2011) Elisa Opitz et al.   PLoS Pathogens

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

(2010) Jacqueline Moebius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lipofuscin inhibits the proteasome by binding to surface motifs

(2010) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

TNF-α Induces Macroautophagy and Regulates MHC Class II Expression in Human Skeletal Muscle Cells

(2010) Christian W. Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation of an ERAD Substrate Occurs on Multiple Types of Amino Acids

(2010) Yuichiro Shimizu et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Ageing enhances α-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians

(2010) Phalguni Anand Alladi et al.   NEUROCHEMISTRY INTERNATIONAL

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Regulation of the 26S Proteasome Complex During Oxidative Stress

(2010) X. Wang et al.   Science Signaling

Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition

(2009) María Paz Gavilán et al.   AGING CELL

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

S-Glutathionylation of the Rpn2 Regulatory Subunit Inhibits 26 S Proteasomal Function

(2009) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin-proteasome system in Alzheimer's disease

(2008) Salvatore Oddo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Age-related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects

(2008) M. Paz Gavilán et al.   JOURNAL OF NEUROCHEMISTRY

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

(2007) Jonathan E. Nuss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

(2007) Bertrand P. Tseng et al.   NEUROBIOLOGY OF AGING