Autophagy in sepsis: Degradation into exhaustion?

Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin

(2015) Katie Maurer et al.   Cell Host & Microbe

Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis

(2015) Alan L. Chang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sinomenine Hydrochloride Protects against Polymicrobial Sepsis via Autophagy

(2015) Yu Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rubicon Deficiency Enhances Cardiac Autophagy and Protects Mice From Lipopolysaccharide-induced Lethality and Reduction in Stroke Volume

(2015) Zhenguo Zi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis

(2015) YunJie Su et al.   Journal of Neuroinflammation

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation

(2015) Qiao Zhang et al.   NATURE IMMUNOLOGY

Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults

(2015) Yaseen M. Arabi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Timing and causes of death in septic shock

(2015) Fabrice Daviaud et al.   Annals of Intensive Care

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

(2014) Annika Klara Giegerich et al.   Autophagy

Endoplasmic reticulum stress-mediated autophagy protects against lipopolysaccharide-induced apoptosis in HL-1 cardiomyocytes

(2014) Xiaojing Zou et al.   EXPERIMENTAL PHYSIOLOGY

Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery

(2014) Virginia Vanasco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vancomycin blocks autophagy and induces interleukin-1β release in macrophages

(2014) Young Eun Ha et al.   JOURNAL OF ANTIBIOTICS

CaMKIV-Dependent Preservation of mTOR Expression Is Required for Autophagy during Lipopolysaccharide-Induced Inflammation and Acute Kidney Injury

(2014) Xianghong Zhang et al.   JOURNAL OF IMMUNOLOGY

Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia

(2014) Alina Aguirre et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

Autophagy-Related IRGM Polymorphism Is Associated with Mortality of Patients with Severe Sepsis

(2014) Tomonori Kimura et al.   PLoS One

T-Cell Autophagy Deficiency Increases Mortality and Suppresses Immune Responses after Sepsis

(2014) Chih-Wen Lin et al.   PLoS One

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice

(2014) Yuki Takaoka et al.   Scientific Reports

Pattern Recognition Receptors and Autophagy

(2014) Ji Eun Oh et al.   Frontiers in Immunology

Carbon Monoxide Confers Protection in Sepsis by Enhancing Beclin 1-Dependent Autophagy and Phagocytosis

(2013) Seonmin Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction

(2013) Jérôme Piquereau et al.   Autophagy

Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

(2013) Minghua Yang et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver

(2013) Evie H. Carchman et al.   FASEB JOURNAL

Septic Shock: On the Importance of Being Tolerant

(2013) Ruslan Medzhitov   IMMUNITY

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Cobalt Protoporphyrin Accelerates TFEB Activation and Lysosome Reformation during LPS-Induced Septic Insults in the Rat Heart

(2013) Kana Unuma et al.   PLoS One

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

(2013) Gina M. Howell et al.   PLoS One

The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

(2013) Xiaoling Gu et al.   PLoS One

Protective Role of AMP-Activated Protein Kinase-Evoked Autophagy on an In Vitro Model of Ischemia/Reperfusion-Induced Renal Tubular Cell Injury

(2013) Li-Ting Wang et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete Activation of Autophagic Process Attenuates Liver Injury and Improves Survival in Septic Mice

(2013) Chih-Wen Lin et al.   SHOCK

Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury

(2013) Yu-Ting Yen et al.   SURGERY

Enhanced Liver Autophagic Activity Improves Survival of Septic Mice Lacking Surfactant Proteins A and D

(2013) Zhe Tang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms

(2013) Maria Eugenia Mansilla Pareja et al.   Frontiers in Cellular and Infection Microbiology

Lc3 Over-Expression Improves Survival and Attenuates Lung Injury Through Increasing Autophagosomal Clearance in Septic Mice

(2012) Steven Lo et al.   ANNALS OF SURGERY

Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: Role of autophagy

(2012) Subat Turdi et al.   FREE RADICAL BIOLOGY AND MEDICINE

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(2012) Yinzhong Zhang et al.   MOLECULAR MEDICINE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Autophagy and Skeletal Muscles in Sepsis

(2012) Mahroo Mofarrahi et al.   PLoS One

Complete Induction of Autophagy Is Essential for Cardioprotection in Sepsis

(2011) Chi-Hsun Hsieh et al.   ANNALS OF SURGERY

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

(2011) Wei Li et al.   BIOCHEMICAL PHARMACOLOGY

Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

(2011) Evie H. Carchman et al.   HEPATOLOGY

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

The helminth product ES-62 protects against septic shock via Toll-like receptor 4–dependent autophagosomal degradation of the adaptor MyD88

(2011) Padmam Puneet et al.   NATURE IMMUNOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Suppression of Autophagy in Rat Liver at Late Stage of Polymicrobial Sepsis

(2011) Wei-Shan Chien et al.   SHOCK

The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis

(2011) Hsiu-Wen Hsiao et al.   SHOCK

Akt2 knockout mitigates chronic iNOS inhibition-induced cardiomyocyte atrophy and contractile dysfunction despite persistent insulin resistance

(2011) Nathan D. Roe et al.   TOXICOLOGY LETTERS

Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy

(2010) Roberta A. Gottlieb et al.   Annual Review of Physiology

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis

(2009) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study

(2009) Eizo Watanabe et al.   LABORATORY INVESTIGATION

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

When apoptosis meets autophagy: deciding cell fate after trauma and sepsis

(2009) Ya-Ching Hsieh et al.   TRENDS IN MOLECULAR MEDICINE

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL