PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Protein kinase R(PKR)–like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015)

(2016) Jeffrey M. Axten   EXPERT OPINION ON THERAPEUTIC PATENTS

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme

(2015) Ojore B.V. Oka et al.   BIOCHEMICAL JOURNAL

Proapoptotic Activities of Protein Disulfide Isomerase (PDI) and PDIA3 Protein, a Role of the Bcl-2 Protein Bak

(2015) Guoping Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I interferons mediate pancreatic toxicities of PERK inhibition

(2015) Qiujing Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics

(2015) Melanie Hussmann et al.   Oncotarget

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6  Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

(2014) A. Higa et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells

(2014) Q Jiang et al.   Cell Death & Disease

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

(2013) W. Zhang et al.   GENES & DEVELOPMENT

Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2)

(2013) K. Janke et al.   JOURNAL OF CELL SCIENCE

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding

(2013) Yoshimi Sato et al.   Scientific Reports

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

(2012) Y. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

(2012) E. Bobrovnikova-Marjon et al.   MOLECULAR AND CELLULAR BIOLOGY

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

(2012) Miri Jwa et al.   NATURE CELL BIOLOGY

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment

(2012) S. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9

(2011) Ulf Brockmeier et al.   PLoS One

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

(2010) Benjamin G Hoffstrom et al.   Nature Chemical Biology

In Vivo Reduction-Oxidation State of Protein Disulfide Isomerase: The Two Active Sites Independently Occur in the Reduced and Oxidized Forms

(2007) Christian Appenzeller-Herzog et al.   ANTIOXIDANTS & REDOX SIGNALING