Interests of the Non-Human Primate Models for HIV Cure Research

Stem cell–derived CAR T cells traffic to HIV reservoirs in macaques

(2021) Isaac M. Barber-Axthelm et al.   JCI Insight

CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques

(2021) Maud Mavigner et al.   JOURNAL OF VIROLOGY

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

(2021) Pablo Tebas et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

(2021) Justin Harper et al.   Nature Communications

Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections

(2021) Nicolas Huot et al.   iScience

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues

(2021) Nicolas Huot et al.   Frontiers in Immunology

Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

(2020) Julia Bergild McBrien et al.   NATURE

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

(2020) Julia Bergild McBrien et al.   NATURE

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

(2020) Christopher C. Nixon et al.   NATURE

African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity

(2020) Kevin D. Raehtz et al.   PLoS Pathogens

It’s Time to Reconsider The Principles of Humane Experimental Technique

(2020) Michael Balls   ATLA-ALTERNATIVES TO LABORATORY ANIMALS

Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils

(2020) Vishnu Hosur et al.   DRUG DISCOVERY TODAY

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

(2020) Justin Harper et al.   NATURE MEDICINE

Small steps forward for HIV vaccine development

(2020) Beatriz Mothe et al.   NATURE MEDICINE

Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

(2020) Donn J. Colby et al.   NATURE MEDICINE

Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies

(2020) Yash Agarwal et al.   Retrovirology

Benefits and limitations of humanized mice in HIV persistence studies

(2020) Matthew D. Marsden   Retrovirology

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques

(2020) Gabriela M. Webb et al.   PLoS Pathogens

Promise and Progress of an HIV-1 Cure by Adeno-Associated Virus Vector Delivery of Anti-HIV-1 Biologics

(2020) Matthew R. Gardner   Frontiers in Cellular and Infection Microbiology

Nanoparticle-Based Immunoengineered Approaches for Combating HIV

(2020) Allan Bowen et al.   Frontiers in Immunology

Robust Expansion of HIV CAR T Cells Following Antigen Boosting in ART-Suppressed Nonhuman Primates

(2020) Blake J. Rust et al.   BLOOD

Recent advances in long-acting nanoformulations for delivery of antiretroviral drugs

(2020) Dhanashree H. Surve et al.   JOURNAL OF CONTROLLED RELEASE

Combination of CD8β depletion and IL-15 superagonist N-803 induces virus reactivation in SHIV-infected, long-term ART-treated rhesus macaques

(2020) Julia B. McBrien et al.   JOURNAL OF VIROLOGY

Therapeutic vaccine-mediated Gag-specific CD8+ T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8+ cells in simian immunodeficiency virus-infected macaques

(2020) Midori Nakamura-Hoshi et al.   Scientific Reports

The Use of Toll-Like Receptor Agonists in HIV-1 Cure Strategies

(2020) Janne Tegder Martinsen et al.   Frontiers in Immunology

Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques

(2020) Maria Pino et al.   Frontiers in Immunology

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

(2020) Jacob T. Martin et al.   npj Vaccines

SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques

(2020) Amir Dashti et al.   JOURNAL OF VIROLOGY

Long-Acting Efavirenz and HIV-1 Fusion Inhibitor Peptide Co-loaded Polymer–Lipid Hybrid Nanoparticles: Statistical Optimization, Cellular Uptake, and In Vivo Biodistribution

(2020) Dhanashree H. Surve et al.   MOLECULAR PHARMACEUTICS

Disease Tolerance as an Inherent Component of Immunity

(2019) Rui Martins et al.   Annual Review of Immunology

The Tat inhibitor didehydro-cortistatin A suppresses SIV replication and reactivation

(2019) Sonia Mediouni et al.   FASEB JOURNAL

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

(2019) Gerlinde Vansant et al.   Retrovirology

NK Response Correlates with HIV Decrease in Pegylated IFN-α2a–Treated Antiretroviral Therapy–Suppressed Subjects

(2019) Emmanouil Papasavvas et al.   JOURNAL OF IMMUNOLOGY

Variation in Intra-individual Lentiviral Evolution Rates: a Systematic Review of Human, Nonhuman Primate, and Felid Species

(2019) Emma Krakoff et al.   JOURNAL OF VIROLOGY

A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

(2019) Scott G. Hansen et al.   Science Translational Medicine

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates

(2019) Joseph R. Francica et al.   PLOS BIOLOGY

Blocking α4β7 integrin binding to SIV does not improve virologic control

(2019) Nami Iwamoto et al.   SCIENCE

Beyond the 3 Rs to a More Comprehensive Framework of Principles for Animal Research Ethics

(2019) David DeGrazia et al.   ILAR JOURNAL

Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques

(2019) Afam A. Okoye et al.   JOURNAL OF IMMUNOLOGY

Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control

(2019) Fredrik Barrenas et al.   Nature Communications

Between a shock and a hard place: challenges and developments in HIV latency reversal

(2019) Jennifer M Zerbato et al.   Current Opinion in Virology

Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence

(2019) Maria Pino et al.   PLoS Pathogens

Targeting Cellular and Tissue HIV Reservoirs With Toll-Like Receptor Agonists

(2019) Amanda B. Macedo et al.   Frontiers in Immunology

Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells

(2019) Leigh Fisher et al.   Frontiers in Immunology

Glycogen synthetase kinase 3 inhibition drives MIC‐A/B to promote cytokine production by human natural killer cells in Dengue virus type 2 infection

(2019) Caroline Petitdemange et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Critical design criteria for engineering a nanoparticulate HIV-1 vaccine

(2019) Stefanie Thalhauser et al.   JOURNAL OF CONTROLLED RELEASE

Why and where an HIV cure is needed and how it might be achieved

(2019) Thumbi Ndung’u et al.   NATURE

Harnessing NK Cells for Cancer Treatment

(2019) Paola Minetto et al.   Frontiers in Immunology

Variation in cell associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator BMAL-1

(2018) Christina C. Chang et al.   AIDS

HIV latency is reversed by ACSS2-driven histone crotonylation

(2018) Guochun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo

(2018) Carolina Garrido et al.   JOURNAL OF VIROLOGY

ElevatedHLA-Aexpression impairs HIV control through inhibition of NKG2A-expressing cells

(2018) Veron Ramsuran et al.   SCIENCE

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

(2018) So-Yon Lim et al.   Science Translational Medicine

Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV Cure Strategies

(2018) Nicolas Huot et al.   Frontiers in Immunology

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

(2018) Pilar Mendoza et al.   NATURE

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

(2018) José Carlos Valle-Casuso et al.   Cell Metabolism

Publisher Correction: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

(2018) Erica N. Borducchi et al.   NATURE

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

(2018) Erica N. Borducchi et al.   NATURE

Refinement, Reduction, and Replacement (3R) Strategies in Preclinical Testing of Medical Devices

(2018) Victoria A. Hampshire et al.   TOXICOLOGIC PATHOLOGY

Human cytomegalovirus-vectored vaccines against HIV

(2018) Maria Abad-Fernandez et al.   Current Opinion in HIV and AIDS

CTLA-4 + PD-1 − Memory CD4 + T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

(2017) Colleen S. McGary et al.   IMMUNITY

Integrin α4β7Blockade Preferentially Impacts CCR6+Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

(2017) Giulia Calenda et al.   JOURNAL OF IMMUNOLOGY

CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering

(2017) Victor I. Ayala et al.   JOURNAL OF VIROLOGY

Tackling HIV and AIDS: contributions by non-human primate models

(2017) Koen K A Van Rompay   LAB ANIMAL

Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection

(2017) P J Santangelo et al.   Mucosal Immunology

Early antibody therapy can induce long-lasting immunity to SHIV

(2017) Yoshiaki Nishimura et al.   NATURE

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

(2017) Nicolas Huot et al.   NATURE MEDICINE

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

(2017) Jenna B Honeycutt et al.   NATURE MEDICINE

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy

(2017) Mariluz Araínga et al.   Retrovirology

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

(2017) John P. Veluchamy et al.   Frontiers in Immunology

Non-human primates in HIV research: Achievements, limits and alternatives

(2016) Thalía Garcia-Tellez et al.   INFECTION GENETICS AND EVOLUTION

In vivo platforms for analysis of HIV persistence and eradication

(2016) J. Victor Garcia   JOURNAL OF CLINICAL INVESTIGATION

Macrophages sustain HIV replication in vivo independently of T cells

(2016) Jenna B. Honeycutt et al.   JOURNAL OF CLINICAL INVESTIGATION

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

(2016) Erica N. Borducchi et al.   NATURE

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

(2016) S. G. Hansen et al.   SCIENCE

Nonhuman primate models for the evaluation of HIV-1 preventive vaccine strategies

(2016) Gregory Q. Del Prete et al.   Current Opinion in HIV and AIDS

Innate immune cell responses in non pathogenic versus pathogenic SIV infections

(2016) Nicolas Huot et al.   Current Opinion in Virology

Humanized mice for HIV and AIDS research

(2016) J Victor Garcia   Current Opinion in Virology

Animal Models for HIV Cure Research

(2016) Benjamin B. Policicchio et al.   Frontiers in Immunology

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

(2015) Lars Pache et al.   Cell Host & Microbe

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

(2015) Luca Micci et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-Term Control of Simian Immunodeficiency Virus (SIV) in Cynomolgus Macaques Not Associated with Efficient SIV-Specific CD8+T-Cell Responses

(2015) Timothée Bruel et al.   JOURNAL OF VIROLOGY

Expansion of Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cell Lines from SIV-Naive Mauritian Cynomolgus Macaques for Adoptive Transfer

(2015) Mariel S. Mohns et al.   JOURNAL OF VIROLOGY

Engineering T Cells to Functionally Cure HIV-1 Infection

(2015) Rachel S Leibman et al.   MOLECULAR THERAPY

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation and microbiome in ARV-treated, SIV-infected macaques

(2015) A M Ortiz et al.   Mucosal Immunology

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Therapeutic Potential and Challenges of Natural Killer Cells in Treatment of Solid Tumors

(2015) Andrea Gras Navarro et al.   Frontiers in Immunology

Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15

(2014) M. Imamura et al.   BLOOD

Molecular Pathways: Targeting Death Receptors and Smac Mimetics

(2014) S. Fulda   CLINICAL CANCER RESEARCH

Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques

(2014) J. D. Estes et al.   JOURNAL OF IMMUNOLOGY

Pathogenic Features Associated with Increased Virulence upon Simian Immunodeficiency Virus Cross-Species Transmission from Natural Hosts

(2014) D. T. Mandell et al.   JOURNAL OF VIROLOGY

Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

(2014) A. Saez-Cirion et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or Not with Interferon-Alpha during Primary SIVagm Infection

(2014) Béatrice Jacquelin et al.   PLoS Pathogens

Macaque Models of Human Infectious Disease

(2013) M. B. Gardner et al.   ILAR JOURNAL

HIV-associated chronic immune activation

(2013) Mirko Paiardini et al.   IMMUNOLOGICAL REVIEWS

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

(2013) Dan H. Barouch et al.   NATURE

bNAber: database of broadly neutralizing HIV antibodies

(2013) Alexey M. Eroshkin et al.   NUCLEIC ACIDS RESEARCH

Host gene evolution traces the evolutionary history of ancient primate lentiviruses

(2013) A. A. Compton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

(2013) S. G. Hansen et al.   SCIENCE

Genetic Modification of Hematopoietic Stem Cells as a Therapy for HIV/AIDS

(2013) Patrick Younan et al.   Viruses-Basel

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

(2013) Suresh Pallikkuth et al.   PLoS Pathogens

SIVagm Infection in Wild African Green Monkeys from South Africa: Epidemiology, Natural History, and Evolutionary Considerations

(2013) Dongzhu Ma et al.   PLoS Pathogens

Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates

(2012) I. Pandrea et al.   BLOOD

SIV Infection Induces Accumulation of Plasmacytoid Dendritic Cells in the Gut Mucosa

(2012) R. K. Reeves et al.   JOURNAL OF INFECTIOUS DISEASES

Shock and kill

(2012) Steven G. Deeks   NATURE

Animal models for HIV/AIDS research

(2012) Theodora Hatziioannou et al.   NATURE REVIEWS MICROBIOLOGY

Natural SIV Hosts: Showing AIDS the Door

(2012) Ann Chahroudi et al.   SCIENCE

Pharmacological Inhibition of Feline Immunodeficiency Virus (FIV)

(2012) Hakimeh Mohammadi et al.   Viruses-Basel

Association of MHC-I genotypes with disease progression in HIV/SIV infections

(2012) Takushi Nomura et al.   Frontiers in Microbiology

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

(2011) Margalida Rotger et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Induction of Polyfunctional Simian Immunodeficiency Virus (SIV)-Specific T Lymphocytes and Rapid Disappearance of SIV from Lymph Nodes of Sooty Mangabeys during Primary Infection

(2011) M. Meythaler et al.   JOURNAL OF IMMUNOLOGY

Immunovirological Analyses of Chronically Simian Immunodeficiency Virus SIVmnd-1- and SIVmnd-2-Infected Mandrills (Mandrillus sphinx)

(2011) C. Apetrei et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

(2011) Mirko Paiardini et al.   NATURE MEDICINE

Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4+ T Cells and Is Reverted by CD8+ Cell Depletion

(2011) Ivona Pandrea et al.   PLoS Pathogens

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection

(2010) R. K. Reeves et al.   BLOOD

Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses

(2010) Brianne R. Barker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasma Proteomic Analysis of Simian Immunodeficiency Virus Infection of Rhesus Macaques

(2010) Jayme L. Wiederin et al.   JOURNAL OF PROTEOME RESEARCH

Simian Immunodeficiency Virus Infection Induces Expansion of  4 7+ and Cytotoxic CD56+ NK Cells

(2010) R. K. Reeves et al.   JOURNAL OF VIROLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation and IL-17 production in the absence of SIV infection

(2010) N R Klatt et al.   Mucosal Immunology

Targeting early infection to prevent HIV-1 mucosal transmission

(2010) Ashley T. Haase   NATURE

Th17 cells in natural SIV hosts

(2010) Mirko Paiardini   Current Opinion in HIV and AIDS

Impact of Simian Immunodeficiency Virus Infection on Chimpanzee Population Dynamics

(2010) Rebecca S. Rudicell et al.   PLoS Pathogens

Probable Deceleration of Progression of Simian AIDS Affected by Opiate Dependency: Studies With a Rhesus Macaque/SIVsmm9 Model

(2009) Robert M Donahoe et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response

(2009) Béatrice Jacquelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

(2009) Steven E. Bosinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

(2009) Brandon F. Keele et al.   NATURE

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

(2009) Donald L Sodora et al.   NATURE MEDICINE

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization

(2009) Sharon Lederer et al.   PLoS Pathogens

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

MHC haplotype frequencies in a UK breeding colony of Mauritian cynomolgus macaques mirror those found in a distinct population from the same geographic origin

(2008) Edward T. Mee et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE