Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence

Bone Marrow-Derived CD4+ T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir

(2018) Timothy N. Hoang et al.   JOURNAL OF VIROLOGY

CTLA-4 + PD-1 − Memory CD4 + T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

(2017) Colleen S. McGary et al.   IMMUNITY

Addendum: Immune clearance of highly pathogenic SIV infection

(2017) Scott G. Hansen et al.   NATURE

Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection

(2017) Geetha H. Mylvaganam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

(2017) Constantinos Petrovas et al.   Science Translational Medicine

PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals

(2016) Riddhima Banga et al.   NATURE MEDICINE

Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

(2016) Hui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Niches in the Bone Marrow: A Hypothesis on Life-long T Cell Memory

(2016) Francesca Di Rosa   TRENDS IN IMMUNOLOGY

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

(2015) Luca Micci et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway

(2014) Achilles Ntranos et al.   JOURNAL OF NEUROIMMUNOLOGY

Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration

(2014) Colette J Smith et al.   LANCET

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

(2014) Alexandra Schuetz et al.   PLoS Pathogens

Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes

(2013) J. C. Mudd et al.   BLOOD

Systemic Effects of Inflammation on Health during Chronic HIV Infection

(2013) Steven G. Deeks et al.   IMMUNITY

The end of AIDS: HIV infection as a chronic disease

(2013) Steven G Deeks et al.   LANCET

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

CD4 T follicular helper cell dynamics during SIV infection

(2012) Constantinos Petrovas et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

(2012) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

Potential mechanisms of efficacy and adverse effects in the use of fingolimod (FTY720)

(2011) Daniel Ontaneda et al.   Expert Review of Clinical Pharmacology

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

(2009) Volker Brinkmann   BRITISH JOURNAL OF PHARMACOLOGY

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

(2007) Kumlesh K. Dev et al.   PHARMACOLOGY & THERAPEUTICS