The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection

Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV‐infected rhesus macaques

(2021) Widade Ziani et al.   FASEB JOURNAL

Lost in translation: Lack of CD4 expression due to a novel genetic defect

(2021) Andrea Lisco et al.   JOURNAL OF INFECTIOUS DISEASES

African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity

(2020) Kevin D. Raehtz et al.   PLoS Pathogens

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

(2020) Justin Harper et al.   NATURE MEDICINE

Nonhuman Primate Testing of the Impact of Different Treg Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus

(2020) Ranjit Sivanandham et al.   JOURNAL OF VIROLOGY

Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia

(2020) Ainhoa Perez-Diez et al.   JOURNAL OF CLINICAL INVESTIGATION

Preserved MAIT cell numbers and function in idiopathic CD4 lymphocytopenia

(2020) Ornella Sortino et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis

(2019) Björn Corleis et al.   Cell Reports

Mucosal T follicular helper cells in SIV-infected rhesus macaques: contributing role of IL-27

(2019) Félicien Moukambi et al.   Mucosal Immunology

Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection

(2019) Assia Samri et al.   PLoS Pathogens

Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post–Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight

(2019) Louise A. Swainson et al.   JOURNAL OF IMMUNOLOGY

Differential dynamics of regulatory T-cell (Treg) and Th17 cell balance in mesenteric lymph nodes and blood following early anti-retroviral initiation during acute SIV infection

(2019) Alexis Yero et al.   JOURNAL OF VIROLOGY

An open-label phase 1 clinical trial of the anti-α4β7 monoclonal antibody vedolizumab in HIV-infected individuals

(2019) Michael C. Sneller et al.   Science Translational Medicine

Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation

(2019) Rosa Anita Fernandes et al.   Frontiers in Immunology

Anti‐ HIV ‐1 antibodies trigger non‐lytic complement deposition on infected cells

(2019) Jérémy Dufloo et al.   EMBO REPORTS

T‐cell exhaustion in HIV infection

(2019) Craig Fenwick et al.   IMMUNOLOGICAL REVIEWS

Author Correction: Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control

(2019) Fredrik Barrenas et al.   Nature Communications

IL-7 treatment supports CD8+ mucosa-associated invariant T-cell restoration in HIV-1-infected patients on antiretroviral therapy

(2018) Ornella Sortino et al.   AIDS

The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques

(2018) Mireille Laforge et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques

(2018) Diane Carnathan et al.   JOURNAL OF VIROLOGY

Regulatory T Cells As Potential Targets for HIV Cure Research

(2018) Adam J. Kleinman et al.   Frontiers in Immunology

Antibody-mediated CD4 depletion induces homeostatic CD4+ T cell proliferation without detectable virus reactivation in ART-treated SIV-infected macaques

(2018) Nitasha A Kumar et al.   JOURNAL OF VIROLOGY

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

(2018) Joseph C. Mudd et al.   Nature Communications

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

(2018) José Carlos Valle-Casuso et al.   Cell Metabolism

Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates

(2018) Ranjit Sivanandham et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone Marrow-Derived CD4+ T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir

(2018) Timothy N. Hoang et al.   JOURNAL OF VIROLOGY

Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner

(2017) Thomas Musich et al.   JOURNAL OF VIROLOGY

Immune activation in prolonged cART-suppressed HIV patients is comparable to that of healthy controls

(2017) Lennert van den Dries et al.   VIROLOGY

Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand

(2017) Jintanat Ananworanich et al.   Journal of the International AIDS Society

Dissecting How CD4 T Cells Are Lost During HIV Infection

(2016) Gilad Doitsh et al.   Cell Host & Microbe

Microbiome alterations in HIV infection a review

(2016) Brett Williams et al.   CELLULAR MICROBIOLOGY

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression

(2016) Henrik N. Kløverpris et al.   IMMUNITY

HIV-specific CD8+ T cells and HIV eradication

(2016) R. Brad Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes

(2016) Tianyu He et al.   JOURNAL OF IMMUNOLOGY

Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques

(2016) Tiffany Hensley-McBain et al.   JOURNAL OF VIROLOGY

Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand

(2016) Merlin L. Robb et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys

(2016) Alexandra M. Ortiz et al.   PLoS One

Magnitude and Kinetics of CD8 + T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point

(2015) Zaza M. Ndhlovu et al.   IMMUNITY

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

(2015) Luca Micci et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue Distribution of Memory T and B Cells in Rhesus Monkeys following Influenza A Infection

(2015) Sathit Pichyangkul et al.   JOURNAL OF IMMUNOLOGY

Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS

(2015) Huanbin Xu et al.   JOURNAL OF IMMUNOLOGY

Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus–Infected Rhesus Macaques May Contribute to Accumulation of TFHin Chronic Infection

(2015) Ankita Chowdhury et al.   JOURNAL OF IMMUNOLOGY

T-Cell Depletion in the Colonic Mucosa of Patients With Idiopathic CD4+Lymphopenia

(2015) Stephen B. Kovacs et al.   JOURNAL OF INFECTIOUS DISEASES

Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors

(2015) Nadeene E. Riddick et al.   JOURNAL OF VIROLOGY

Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin

(2015) Zhaohui Wang et al.   Molecular Oncology

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation and microbiome in ARV-treated, SIV-infected macaques

(2015) A M Ortiz et al.   Mucosal Immunology

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

(2015) Xing Pei Hao et al.   Nature Communications

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

(2015) Ivan Vujkovic-Cvijin et al.   Cell Reports

Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques

(2015) Félicien Moukambi et al.   PLoS Pathogens

Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication

(2014) Jan Kristoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

(2014) I. Pandrea et al.   JOURNAL OF IMMUNOLOGY

Immune Activation Driven by CTLA-4 Blockade Augments Viral Replication at Mucosal Sites in Simian Immunodeficiency Virus Infection

(2014) V. Cecchinato et al.   JOURNAL OF IMMUNOLOGY

Divergent CD4+ T Memory Stem Cell Dynamics in Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infections

(2014) E. K. Cartwright et al.   JOURNAL OF IMMUNOLOGY

The Kynurenine Pathway of Tryptophan Catabolism, CD4+ T-Cell Recovery, and Mortality Among HIV-Infected Ugandans Initiating Antiretroviral Therapy

(2014) H. Byakwaga et al.   JOURNAL OF INFECTIOUS DISEASES

Increased Stability and Limited Proliferation of CD4+ Central Memory T Cells Differentiate Nonprogressive Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabeys from Progressive SIV Infection of Rhesus Macaques

(2014) C. S. McGary et al.   JOURNAL OF VIROLOGY

Pathogenic Features Associated with Increased Virulence upon Simian Immunodeficiency Virus Cross-Species Transmission from Natural Hosts

(2014) D. T. Mandell et al.   JOURNAL OF VIROLOGY

Factors Associated with Siman Immunodeficiency Virus Transmission in a Natural African Nonhuman Primate Host in the Wild

(2014) D. Ma et al.   JOURNAL OF VIROLOGY

Idiopathic CD4 Lymphocytopenia

(2014) Alexis Régent et al.   MEDICINE

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

(2014) James B. Whitney et al.   NATURE

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

(2014) Siddappa N Byrareddy et al.   NATURE MEDICINE

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

(2014) Luca Micci et al.   PLoS Pathogens

Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

(2014) Alexandra Schuetz et al.   PLoS Pathogens

Incidence of Types of Cancer among HIV-Infected Persons Compared with the General Population in the United States, 1992–2003

(2013) Pragna Patel et al.   ANNALS OF INTERNAL MEDICINE

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

Systemic Effects of Inflammation on Health during Chronic HIV Infection

(2013) Steven G. Deeks et al.   IMMUNITY

Superior T memory stem cell persistence supports long-lived T cell memory

(2013) Enrico Lugli et al.   JOURNAL OF CLINICAL INVESTIGATION

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

(2013) Nichole R. Klatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Dynamics of Immune Reconstitution and Activation Markers in HIV+ Treatment-Naïve Patients Treated with Raltegravir, Tenofovir Disoproxil Fumarate and Emtricitabine

(2013) Nicholas T. Funderburg et al.   PLoS One

Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

(2013) Mohammad-Ali Jenabian et al.   PLoS One

Semen CD4+ T Cells and Macrophages Are Productively Infected at All Stages of SIV infection in Macaques

(2013) Sibylle Bernard-Stoecklin et al.   PLoS Pathogens

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

(2013) Suresh Pallikkuth et al.   PLoS Pathogens

Multifunctional Double-negative T Cells in Sooty Mangabeys Mediate T-helper Functions Irrespective of SIV Infection

(2013) Vasudha Sundaravaradan et al.   PLoS Pathogens

SIVagm Infection in Wild African Green Monkeys from South Africa: Epidemiology, Natural History, and Evolutionary Considerations

(2013) Dongzhu Ma et al.   PLoS Pathogens

Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates

(2012) I. Pandrea et al.   BLOOD

Paucity of IL-21-producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques

(2012) L. Micci et al.   BLOOD

Immune Responses Driven by Protective Human Leukocyte Antigen Alleles From Long-term Nonprogressors Are Associated With Low HIV Reservoir in Central Memory CD4 T Cells

(2012) Benjamin Descours et al.   CLINICAL INFECTIOUS DISEASES

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

(2012) Madelene Lindqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4 T follicular helper cell dynamics during SIV infection

(2012) Constantinos Petrovas et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute and Chronic T Cell Dynamics in the Livers of Simian Immunodeficiency Virus-Infected Macaques

(2012) M. H. Ahsan et al.   JOURNAL OF VIROLOGY

Mucosal Simian Immunodeficiency Virus Transmission in African Green Monkeys: Susceptibility to Infection Is Proportional to Target Cell Availability at Mucosal Sites

(2012) Ivona Pandrea et al.   JOURNAL OF VIROLOGY

Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection

(2012) N R Klatt et al.   Mucosal Immunology

IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques

(2012) H Xu et al.   Mucosal Immunology

A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis

(2012) C J Kim et al.   Mucosal Immunology

A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia

(2011) M. M. Gorska et al.   BLOOD

Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection

(2011) R. K. Reeves et al.   BLOOD

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells

(2011) Jeffrey M. Milush et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of CD4+ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

(2011) Alexandra M. Ortiz et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunovirological Analyses of Chronically Simian Immunodeficiency Virus SIVmnd-1- and SIVmnd-2-Infected Mandrills (Mandrillus sphinx)

(2011) C. Apetrei et al.   JOURNAL OF VIROLOGY

CD4 T Cell Depletion at the Cervix during HIV Infection Is Associated with Accumulation of Terminally Differentiated T Cells

(2011) P. P. Gumbi et al.   JOURNAL OF VIROLOGY

CD4-Like Immunological Function by CD4- T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

(2011) C. Vinton et al.   JOURNAL OF VIROLOGY

CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors

(2011) E. J. Ciccone et al.   JOURNAL OF VIROLOGY

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

(2011) Mirko Paiardini et al.   NATURE MEDICINE

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure

(2011) A. W. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV/SIV Infection Primes Monocytes and Dendritic Cells for Apoptosis

(2011) Mireille Laforge et al.   PLoS Pathogens

Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4+ T Cells and Is Reverted by CD8+ Cell Depletion

(2011) Ivona Pandrea et al.   PLoS Pathogens

HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells

(2010) Andrew Prendergast et al.   AIDS

Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates

(2010) J. C. Engram et al.   BLOOD

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

Loss of mucosal CD4 lymphocytes is an early feature of HIV infection

(2010) S. G. LIM et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Despite being highly diverse, immunovirological status strongly correlates with clinical symptoms during primary HIV-1 infection: a cross-sectional study based on 674 patients enrolled in the ANRS CO 06 PRIMO cohort

(2010) J. Ghosn et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Blocking of  4 7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2010) A. A. Ansari et al.   JOURNAL OF IMMUNOLOGY

Pattern of SIVagm Infection in Patas Monkeys Suggests that Host Adaptation to Simian Immunodeficiency Virus Infection May Result in Resistance to Infection and Virus Extinction

(2010) Cristian Apetrei et al.   JOURNAL OF INFECTIOUS DISEASES

Gut Mucosal FOXP3+ Regulatory CD4+ T Cells and Nonregulatory CD4+ T Cells Are Differentially Affected by Simian Immunodeficiency Virus Infection in Rhesus Macaques

(2010) K. Allers et al.   JOURNAL OF VIROLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys

(2010) M. L. Chan et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Biomarkers of immune dysfunction in HIV

(2010) Daniel E Nixon et al.   Current Opinion in HIV and AIDS

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

HIV increases markers of cardiovascular risk: results from a randomized, treatment interruption trial

(2009) Alexandra Calmy et al.   AIDS

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

(2009) M. A. Brockman et al.   BLOOD

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

The level of monocyte turnover predicts disease progression in the macaque model of AIDS

(2009) A. Hasegawa et al.   BLOOD

Depletion of CD4+ T Cells in Semen During HIV Infection and Their Restoration Following Antiretroviral Therapy

(2009) Joseph A Politch et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

(2009) Karin R. Engelhardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Yogurt Containing Probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 Helps Resolve Moderate Diarrhea and Increases CD4 Count in HIV/AIDS Patients

(2009) Kingsley C. Anukam et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response

(2009) Béatrice Jacquelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment

(2009) Yves Levy et al.   JOURNAL OF CLINICAL INVESTIGATION

IFN-  Inhibits Human Th17 Cell Differentiation

(2009) V. S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

AIDS Progression Is Associated with the Emergence of IL-17-Producing Cells Early After Simian Immunodeficiency Virus Infection

(2009) L. Campillo-Gimenez et al.   JOURNAL OF IMMUNOLOGY

Combined Effect of Antiretroviral Therapy and Blockade of IDO in SIV-Infected Rhesus Macaques

(2009) A. Boasso et al.   JOURNAL OF IMMUNOLOGY

Evidence for Translocation of Microbial Products in Patients with Idiopathic CD4 Lymphocytopenia

(2009) Philip I. Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Monitoring α4β7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection

(2009) X Wang et al.   Mucosal Immunology

Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels

(2009) E J Ciccone et al.   Mucosal Immunology

α4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection

(2009) M Kader et al.   Mucosal Immunology

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

(2009) Coreen M Beaumier et al.   NATURE MEDICINE

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Combined Immunodeficiency Associated withDOCK8Mutations

(2009) Qian Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors

(2008) D. I. Zonios et al.   BLOOD

Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys

(2008) Nichole R. Klatt et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism

(2008) Olivier Manches et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cell Dynamics and Alpha Interferon Production during Simian Immunodeficiency Virus Infection with a Nonpathogenic Outcome

(2008) O. M. Diop et al.   JOURNAL OF VIROLOGY

Differential CD4+ T-Lymphocyte Apoptosis and Bystander T-Cell Activation in Rhesus Macaques and Sooty Mangabeys during Acute Simian Immunodeficiency Virus Infection

(2008) M. Meythaler et al.   JOURNAL OF VIROLOGY

Paucity of CD4+ CCR5+ T Cells May Prevent Transmission of Simian Immunodeficiency Virus in Natural Nonhuman Primate Hosts by Breast-Feeding

(2008) I. Pandrea et al.   JOURNAL OF VIROLOGY

Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4+ T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells

(2008) D. Verhoeven et al.   JOURNAL OF VIROLOGY

Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

(2008) V Cecchinato et al.   Mucosal Immunology

Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses

(2008) M Macal et al.   Mucosal Immunology

Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

(2008) Manuela Raffatellu et al.   NATURE MEDICINE

Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts

(2008) Ivona Pandrea et al.   TRENDS IN IMMUNOLOGY

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE