The role of M6A modification in the regulation of tumor-related lncRNAs

A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability

(2021) Pengpeng Zhu et al.   ONCOGENE

N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles

(2021) Xinyu Wang et al.   DEVELOPMENTAL CELL

LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification

(2021) Pingfu Hou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma

(2021) Jie Shen et al.   LABORATORY INVESTIGATION

m6A-Mediated Upregulation of LINC00857 Promotes Pancreatic Cancer Tumorigenesis by Regulating the miR-150-5p/E2F3 Axis

(2021) Xiangrui Meng et al.   Frontiers in Oncology

m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis

(2021) Dongwen Rong et al.   Cell Death Discovery

ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma

(2020) Shuo Chen et al.   Cancer Cell International

RNA N6-methyladenosine modification in solid tumors: new therapeutic frontiers

(2020) Laleh Melstrom et al.   CANCER GENE THERAPY

Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development

(2020) Yue Hu et al.   CELL DEATH AND DIFFERENTIATION

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

(2020) Bo Tang et al.   Molecular Cancer

METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

(2020) Xiao Yang et al.   Molecular Cancer

SPEN integrates transcriptional and epigenetic control of X-inactivation

(2020) François Dossin et al.   NATURE

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

(2020) Tao Liu et al.   NUCLEIC ACIDS RESEARCH

HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle

(2020) Denise Jurczyszak et al.   PLoS Pathogens

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

(2020) Min Han et al.   Frontiers in Neuroscience

Heat Shock Protein 90 Chaperone Regulates the E3 Ubiquitin-Ligase Hakai Protein Stability

(2020) Díaz-Díaz et al.   Cancers

Long non-coding RNA RHPN1-AS1 promotes tumorigenesis and metastasis of ovarian cancer by acting as a ceRNA against miR-596 and upregulating LETM1

(2020) Junrong Wang et al.   Aging-US

Long Noncoding RNA HOTAIR Contributes to Progression in Hepatocellular Carcinoma by Sponging miR-217-5p

(2020) Ximing Gong et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

A Novel Micropeptide Encoded by Y-Linked LINC00278 Links Cigarette Smoking and AR Signaling in Male Esophageal Squamous Cell Carcinoma

(2020) Siqi Wu et al.   CANCER RESEARCH

Exosomal Long Non-Coding RNAs in Lung Diseases

(2020) Christophe Poulet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification

(2020) Ryoma Yoneda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer

(2020) Yi Chen et al.   Molecular Cancer

Long non-coding RNA H19, a novel therapeutic target for pancreatic cancer

(2020) Jing Wang et al.   MOLECULAR MEDICINE

LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma

(2020) Yuanyuan Ban et al.   Molecular Oncology

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

(2020) Song Zhu et al.   Nature Communications

VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer

(2020) Daniela Barros-Silva et al.   Cancers

Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival

(2020) Yan Geng et al.   Annals of Translational Medicine

When the Smoke Clears m6A from a Y Chromosome–Linked lncRNA, Men Get an Increased Risk of Cancer

(2020) A. Rouf Banday et al.   CANCER RESEARCH

The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs

(2020) Lele Zhang et al.   Molecular Cancer

LNC942 promoting METTL14-mediated m6A methylation in breast cancer cell proliferation and progression

(2020) Tong Sun et al.   ONCOGENE

Long non-coding RNAs in hepatocellular carcinoma: Ordering of the complicated lncRNA regulatory network and novel strategies for HCC clinical diagnosis and treatment

(2020) Changyao Li et al.   PHARMACOLOGICAL RESEARCH

Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies

(2020) Zhen-Hua Chen et al.   Cell Death & Disease

m 6 A transferase METTL3‐induced lncRNA ABHD11‐AS1 promotes the Warburg effect of non‐small‐cell lung cancer

(2020) Lei Xue et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression

(2020) Chuandong Cheng et al.   CANCER GENE THERAPY

DMDRMR-mediated regulation of m6A-modified CDK4 by m6A reader IGF2BP3 drives ccRCC progression

(2020) Shan Gao et al.   CANCER RESEARCH

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

(2020) Simeng Wen et al.   Molecular Cancer

The Pseudogene Olfr29-ps1 Promotes the Suppressive Function and Differentiation of Monocytic MDSCs

(2019) Wencong Shang et al.   Cancer Immunology Research

LncRNA Riken-201 and Riken-203 modulates neural development by regulating the Sox6 through sequestering miRNAs

(2019) Lei Zhang et al.   CELL PROLIFERATION

LncRNA FOXD1‐AS1 acts as a potential oncogenic biomarker in glioma

(2019) Yuan‐Feng Gao et al.   CNS Neuroscience & Therapeutics

Tumor‐derived exosomal lncRNA GAS5 as a biomarker for early‐stage non‐small‐cell lung cancer diagnosis

(2019) Chuling Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1

(2019) Yingmin Wu et al.   Molecular Cancer

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3

(2019) Zi-Qi Zheng et al.   CANCER RESEARCH

Genome‐wide identification of lncRNAs as novel prognosis biomarkers of glioma

(2019) Lianhao Song et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

In silico genome-wide identification of m6A-associated SNPs as potential functional variants for periodontitis

(2019) Weimin Lin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs

(2019) Chao-Jie Wang et al.   Molecular Cancer

The dynamics of FTO binding and demethylation from the m6A motifs

(2019) Yixing Li et al.   RNA Biology

lncRNA expression predicts mRNA abundance

(2019) Alicja Pacholewska et al.   Epigenomics

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

(2019) Seungwon Yang et al.   Nature Communications

Identification of lncRNA biomarkers in lung squamous cell carcinoma using comprehensive analysis of lncRNA mediated ceRNA network

(2019) Rui Li et al.   Artificial Cells Nanomedicine and Biotechnology

Role of identified RNA N6-methyladenosine methylation in liver

(2019) Kechen Xu et al.   ANALYTICAL BIOCHEMISTRY

The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1

(2019) Wujun Miao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The how and why of lncRNA function: An innate immune perspective

(2019) Elektra K. Robinson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Survival analysis of immune-related lncRNA in low-grade glioma

(2019) Xiaozhi Li et al.   BMC CANCER

Portrait of Tissue-Specific Coexpression Networks of Noncoding RNAs (miRNA and lncRNA) and mRNAs in Normal Tissues

(2019) Claudia Cava et al.   Computational and Mathematical Methods in Medicine

The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development

(2019) Nicole Ritter et al.   DEVELOPMENTAL CELL

Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1

(2019) Chenlong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Integration analysis for novel lncRNA markers predicting tumor recurrence in human colon adenocarcinoma

(2019) Fangyao Chen et al.   Journal of Translational Medicine

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion

(2019) Tianfang Xia et al.   PATHOLOGY RESEARCH AND PRACTICE

The role of mRNA m6A methylation in the nervous system

(2019) Jiashuo Li et al.   Cell and Bioscience

lnc RNA HOTAIR promotes gastric cancer proliferation and metastasis via targeting miR‐126 to active CXCR 4 and RhoA signaling pathway

(2019) Jun Xiao et al.   Cancer Medicine

The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing

(2019) Hayley J. Luxton et al.   Cancers

LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells

(2019) Jijun Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs

(2019) Phillip J. Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LncRNA PCED1B‐AS1 activates the proliferation and restricts the apoptosis of glioma through cooperating with miR‐194‐5p/PCED1B axis

(2019) Jinghui Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The interplay between m6A RNA methylation and noncoding RNA in cancer

(2019) Shuai Ma et al.   Journal of Hematology & Oncology

METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway

(2019) Jinghua Wang et al.   MEDIATORS OF INFLAMMATION

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

(2019) Wen Ni et al.   Molecular Cancer

YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma

(2019) Jiajie Hou et al.   Molecular Cancer

Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

(2019) Katherine I. Zhou et al.   MOLECULAR CELL

Emerging Roles of Long Non-Coding RNAs as Drivers of Brain Evolution

(2019) Geraldine Zimmer-Bensch   Cells

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

Changes in m6A RNA methylation contribute to heart failure progression by modulating translation

(2019) Tea Berulava et al.   EUROPEAN JOURNAL OF HEART FAILURE

N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

(2019) Bin-bin Hu et al.   Molecular Cancer

KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3

(2019) Tian Lan et al.   Molecular Cancer

Integrative network analysis identifies cell-specific trans regulators of m6A

(2019) Sanqi An et al.   NUCLEIC ACIDS RESEARCH

Circulating lncRNA UCA1 Promotes Malignancy of Colorectal Cancer via the miR-143/MYO6 Axis

(2019) Yunpeng Luan et al.   Molecular Therapy-Nucleic Acids

Multiple Functions and Mechanisms Underlying the Role of METTL3 in Human Cancers

(2019) Wenhui Zheng et al.   Frontiers in Oncology

Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm

(2019) Yuchen He et al.   Annals of Translational Medicine

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation

(2018) Yuan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

mRNA, microRNA and lncRNA as novel bladder tumor markers

(2018) Edyta Wieczorek et al.   CLINICA CHIMICA ACTA

LncKdm2b controls self‐renewal of embryonic stem cells via activating expression of transcription factor Zbtb3

(2018) Buqing Ye et al.   EMBO JOURNAL

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

MALAT1 promotes the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation

(2018) Chuanqing Wu et al.   MOLECULAR CARCINOGENESIS

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription

(2018) Shi-jiang Deng et al.   ONCOGENE

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

(2018) Baixing Wu et al.   Nature Communications

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

(2018) Seth D. Kasowitz et al.   PLoS Genetics

A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration

(2018) Zong-Kang Zhang et al.   Journal of Cachexia Sarcopenia and Muscle

m6A modification of non-coding RNA and the control of mammalian gene expression

(2018) Heather Coker et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mechanistic insights into m6A RNA enzymes

(2018) Tina Lence et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Research progresses in roles of LncRNA and its relationships with breast cancer

(2018) Xu Bin et al.   Cancer Cell International

Nutrient stress-dysregulated antisense lncRNA GLS-AS impairs GLS-mediated metabolism and represses pancreatic cancer progression

(2018) Shi-jiang Deng et al.   CANCER RESEARCH

A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

(2018) Rong Wu et al.   CELL RESEARCH

Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression

(2018) JiaLing Chen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

LncRNA as a diagnostic and prognostic biomarker in bladder cancer: a systematic review and meta-analysis

(2018) Jing Quan et al.   OncoTargets and Therapy

The Dark Side of the Epitranscriptome: Chemical Modifications in Long Non-Coding RNAs

(2017) Roland Jacob et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Current Insights into Long Non-Coding RNAs (LncRNAs) in Prostate Cancer

(2017) Maria Smolle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome

(2017) A. Emilia Arguello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling

(2017) Peng Han et al.   Molecular Cancer

Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI

(2017) Kamil Růžička et al.   NEW PHYTOLOGIST

ALKBH10B Is an RNAN6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition

(2017) Hong-Chao Duan et al.   PLANT CELL

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA Modification N 6 -methyladenosine and Its Implications in Human Disease

(2017) Pedro J. Batista   GENOMICS PROTEOMICS & BIOINFORMATICS

A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma

(2016) Qixue Wang et al.   CANCER LETTERS

Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression

(2016) Roland Elling et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Long Noncoding RNAs

(2016) Reinier A. Boon et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Recent advances in dynamic m6A RNA modification

(2016) Guangchao Cao et al.   Open Biology

Evolutionary clues in lncRNAs

(2016) Anne Nitsche et al.   Wiley Interdisciplinary Reviews-RNA

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

N 6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases

(2015) Arpita Maity et al.   FEBS Journal

CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis

(2015) Samir Ounzain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer

(2015) Xiaoying Zhou et al.   Scientific Reports

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

The evolution of lncRNA repertoires and expression patterns in tetrapods

(2014) Anamaria Necsulea et al.   NATURE

Genomic Imprinting in Mammals

(2014) D. P. Barlow et al.   Cold Spring Harbor Perspectives in Biology

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA

(2013) N. Liu et al.   RNA

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

Long noncoding RNAs: functional surprises from the RNA world

(2009) J. E. Wilusz et al.   GENES & DEVELOPMENT

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE