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Biochemistry & Molecular Biology
Xiufeng Hu, Yu Mu, Jiaojie Wang, Yanqiu Zhao
Summary: This study demonstrates that TDRG1 is significantly overexpressed in NSCLC, and interacts with miR-873-5p to positively regulate the expression of ZEB1, thereby facilitating the progression of NSCLC.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Jianbing Hou, Minghao Xu, Hongyu Gu, Dakun Pei, Yudong Liu, Pan Huang, Hongbo Chang, Hongjuan Cui
Summary: ZC3H15, an overexpressed protein in GBM, promotes the proliferation, migration, invasion, and tumorigenesis of GBM cells by activating the EGFR signaling pathway. High expression of ZC3H15 is associated with poor patient survival.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Haifeng Ni, Chengxian Liang, Zhen Zhou, Bo Jiang, Yong Li, Haiqiong Shang, Xiaoyu Yu
Summary: METTL13 up-regulated ZEB1, which facilitated the transcriptional activation of TPT1, ultimately promoting the growth and metastasis of nasopharyngeal carcinoma (NPC), providing a potential therapeutic strategy for NPC treatment.
JOURNAL OF GENE MEDICINE
(2023)
Article
Oncology
Shuyi Han, Yan Qi, Yihui Xu, Min Wang, Jun Wang, Jing Wang, Mingjie Yuan, Yanfei Jia, Xiaoli Ma, Yunshan Wang, Xiangdong Liu
Summary: DLEU2 is significantly up-regulated in GC tissues and cell lines, associated with pathological grading and TNM stage of GC patients. MiR-30a-5p can directly bind to the 3' UTR region of ETS2. DLEU2 binds to miR-30a-5p to facilitate ETS2 expression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yan Jin, Zhengming Zhang, Qiao Yu, Zhu Zeng, Hong Song, Xiaoxu Huang, Qi Kong, Hao Hu, Yabin Xia
Summary: The research revealed that ZEB1-AS1 was significantly upregulated in pancreatic cancer cells under hypoxia conditions, correlating with poor prognosis in patients. ZEB1-AS1 facilitates the transcription of ZEB1 and stabilization of HIF-1α, promoting metastasis in pancreatic cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Shuhong Dai, Ning Li, Ming Zhou, Yue Yuan, Ding Yue, Tao Li, Xiaowei Zhang
Summary: The study investigated the role of EBLN3P in osteosarcoma progression by modulating the miR-224-5p/Rab10 pathway, leading to enhanced cell proliferation, migration, and invasion. This finding suggests a potential new approach to diagnosing and treating osteosarcoma.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Bo Chen, Mei Feng, Zhongyang Yao, Zhiwen Zhang, Kaining Zhang, Liguang Zhou
Summary: Hypoxia is a crucial factor in promoting cervical lymph node metastasis and recurrence in thyroid cancer. The upregulation of FGF11 in hypoxic thyroid cancer cells and tissues, along with its positive feedback loop with HIF1α, enhances the growth and metastasis of thyroid cancer cells.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yao Wang, Yuanyuan Guo, Tianchi Zhuang, Ting Xu, Minghui Ji
Summary: Growing evidence suggests that LINC00659, a newly identified long noncoding RNA, plays a critical role in gastric cancer. Upregulation of LINC00659 is associated with tumor progression, lymphatic metastasis, and poorer prognosis. It functions as a competing endogenous RNA for miR-370, leading to the upregulation of its target gene AQP3. This study provides insights into the pathogenesis of gastric cancer and may contribute to the identification of potential therapeutic targets.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Zhihui Wen, Jingbo Sun, Junjie Luo, Yun Fu, Yue Qiu, Yanyan Li, Yangwei Xu, Hongmei Wu, Qingling Zhang
Summary: The high expression of COL10A1 in pancreatic cancer cells and tissues is associated with poor prognosis and clinicopathological features. COL10A1 regulates PDAC cell proliferation and MEK/ERK signaling pathways by binding to DDR2, promoting migration, invasion, and EMT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yen-Yun Wang, Anupama Vadhan, Ping-Ho Chen, Yen-Lung Lee, Chih-Yeh Chao, Kuang-Hung Cheng, Yu-Chiuan Chang, Stephen Chu-Sung Hu, Shyng-Shiou F. Yuan
Summary: The study investigated the role of CD44 in lung cancer metastasis through clinical, in vitro, and in vivo studies, revealing that CD44 promotes migration and invasion abilities of lung cancer cells. Understanding and targeting CD44 may offer potential therapeutic strategies to decrease lung cancer metastasis.
Article
Cell Biology
Yong Chen, Guoqing Tang, Hongbin Qian, Ji Chen, Bing Cheng, Chengliang Zhou, Yixin Shen
Summary: In this study, it was found that lncRNA LOC100129620 promotes the proliferation and migration of osteosarcoma cells by regulating miR-335-3p and CDK6, thereby promoting the metastasis of osteosarcoma.
Article
Cell Biology
Weiwen Zhu, Jie Wang, Xiang Liu, Yanbin Xu, Rundong Zhai, Jiayi Zhang, Mengqi Wang, Mengyao Wang, Laikui Liu
Summary: Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral and maxillofacial region, severely affects human health. In this study, researchers identified a long non-coding RNA called CYTOR, which is highly expressed in oral cancer patients. They found that CYTOR promotes cell migration and invasion, and affects mitochondrial metabolism and RNA splicing in oral cancer cells.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xin Yue, Wen-ying Wu, Ma Dong, Meng Guo
Summary: MALAT1 is highly expressed in breast cancer tissues and cells, promoting proliferation, migration, invasion, and doxorubicin resistance. Through targeting miR-570-3p, MALAT1 plays a pivotal role in regulating breast cancer progression and drug resistance.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yingwei Li, Zhongshao Chen, Jiali Peng, Cunzhong Yuan, Shi Yan, Ning Yang, Peng Li, Beihua Kong
Summary: This study found that SNRPB plays a key role in ovarian cancer and is associated with poor prognosis. Functionally, SNRPB knockdown inhibits ovarian cancer cell proliferation and invasion, while overexpression has the opposite effect. SNRPB expression increases after cisplatin treatment, and silencing SNRPB enhances ovarian cancer cell sensitivity to cisplatin. SNRPB promotes ovarian cancer progression by repressing exon 3 skipping of POLA1 and BRCA2.
Article
Oncology
Huan Deng, Jingwang Gao, Bo Cao, Ziyu Qiu, Tian Li, Ruiyang Zhao, Hanghang Li, Bo Wei
Summary: The study identified that the lncRNA CCAT2 is overexpressed in gastric cancer tissues and correlated with poor patient prognosis. CCAT2 promotes proliferation, migration, and invasion of gastric cancer cells, and regulates alternative splicing of CD44 by binding to ESRP1. This CCAT2/ESRP1/CD44 axis plays an oncogenic role in promoting gastric cancer progression.
Article
Oncology
Shi-Jiang Deng, Heng-Yu Chen, Zhu Zeng, Shichang Deng, Shuai Zhu, Zeng Ye, Chi He, Ming-Liang Liu, Kang Huang, Jian-Xin Zhong, Feng-Yu Xu, Qiang Li, Yang Liu, Chunyou Wang, Gang Zhao
Article
Biotechnology & Applied Microbiology
Kang Huang, Tudi Pang, Changjun Tong, Houqing Chen, Yupeng Nie, Jiayi Wu, Yandong Zhang, Ganghong Chen, Wei Zhou, Dazhi Yang
Summary: DHX37, a putative RNA helicase involved in various RNA structural processes, is significantly upregulated in human cancers, with mutations present and correlating with immune-related genes. It is enriched in cancer-related pathways and may serve as a potential target for cancer immunotherapy.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Chang-Jun Tong, Qing-Chun Deng, Di-Jun Ou, Xia Long, He Liu, Kang Huang
Summary: The upregulation of lncRNA RUSC1-AS1 in osteosarcoma promotes cell proliferation, invasion, and inhibits apoptosis, as well as enhances the epithelial-mesenchymal transition (EMT) process. Inhibition of RUSC1-AS1 also showed suppressive effects on tumor growth in vivo, indicating its potential as a therapeutic target for osteosarcoma.
Article
Medicine, Research & Experimental
Zhu Zeng, Feng-yu Xu, Hai Zheng, Ping Cheng, Qing-yong Chen, Zeng Ye, Jian-xin Zhong, Shi-jiang Deng, Ming-liang Liu, Kang Huang, Qiang Li, Wei Li, Yu-hang Hu, Fan Wang, Chun-you Wang, Gang Zhao
Article
Medicine, Research & Experimental
Mingliang Liu, Jianxin Zhong, Zhu Zeng, Kang Huang, Zeng Ye, Shijiang Deng, Hengyu Chen, Fengyu Xu, Qiang Li, Gang Zhao