Agmatine Alleviates Epileptic Seizures and Hippocampal Neuronal Damage by Inhibiting Gasdermin D-Mediated Pyroptosis

Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-κB Signaling Pathway

(2020) Wei Zhang et al.   Biomed Research International

Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice

(2020) Nandkishor Kotagale et al.   NEUROTOXICOLOGY

Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation

(2019) Jennifer L. McCurtain et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

Evaluation of IL-1β levels in epilepsy and traumatic brain injury in dogs

(2019) Draginja Kostic et al.   BMC NEUROSCIENCE

Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome

(2019) Shikuo Rong et al.   Frontiers in Pharmacology

Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-κB Signaling Pathway

(2019) Xuanfei Li et al.   CRITICAL CARE MEDICINE

Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome

(2018) Bo Gao et al.   Journal of Neuroinflammation

Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening

(2018) Daniela M. Magalhães et al.   Journal of Neuroinflammation

Microglia after Seizures and in Epilepsy

(2018) Toshimitsu Hiragi et al.   Cells

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

(2018) Hye Yeon Nam et al.   Journal of Neuroinflammation

Microglial phenotypes in the human epileptic temporal lobe

(2018) Mélanie Morin-Brureau et al.   BRAIN

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy

(2017) Shirong Tang et al.   Scientific Reports

Prevalence of epilepsy in China between 1990 and 2015: A systematic review and meta–analysis

(2017) Peige Song et al.   Journal of Global Health

Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats

(2016) Yonglin Zhao et al.   MEDIATORS OF INFLAMMATION

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Prevalence and incidence of epilepsy

(2016) Kirsten M. Fiest et al.   NEUROLOGY

Anticonvulsant effect of piperine ameliorates memory impairment, inflammation and oxidative stress in a rat model of pilocarpine-induced epilepsy

(2016) Ke Mao et al.   Experimental and Therapeutic Medicine

Erratum: Corrigendum: Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism

(2016) Alberto E. Musto et al.   Scientific Reports

Gasdermin D: the long-awaited executioner of pyroptosis

(2015) Si Ming Man et al.   CELL RESEARCH

Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury

(2015) Jae Young Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Curcumin attenuates inflammatory response and cognitive deficits in experimental model of chronic epilepsy

(2015) Harpreet Kaur et al.   NEUROCHEMISTRY INTERNATIONAL

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(2014) Xiang-Fei Meng et al.   Journal of Neuroinflammation

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy

(2014) X Li et al.   Cell Death & Disease

High dosage of agmatine alleviates pentylenetetrazole-induced chronic seizures in rats possibly by exerting an anticonvulsive effect

(2014) HUIQIN XU et al.   Experimental and Therapeutic Medicine

Love and death: microglia, NLRP3 and the Alzheimer's brain

(2013) Tobias Goldmann et al.   CELL RESEARCH

Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus

(2013) Zhen Li et al.   NEUROREPORT

Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine

(2013) Borna Payandemehr et al.   PHYSIOLOGY & BEHAVIOR

Neuroprotective effects of agmatine in mice infused with a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

(2012) Filipe C. Matheus et al.   BEHAVIOURAL BRAIN RESEARCH

Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity

(2012) Soo Kyung Ahn et al.   LIFE SCIENCES

Réponse inflammatoire et anti-inflammatoire de l’hôte au cours du sepsis

(2012) M. Adib-Conquy et al.   PATHOLOGIE BIOLOGIE

Brain inflammation as a biomarker in epilepsy

(2011) Annamaria Vezzani et al.   Biomarkers in Medicine

Molecular cascades that mediate the influence of inflammation on epilepsy

(2011) Alon Friedman et al.   EPILEPSIA

The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis

(2011) Alberto E. Musto et al.   EPILEPSIA

Glia as a source of cytokines: Implications for neuronal excitability and survival

(2010) Annamaria Vezzani et al.   EPILEPSIA

Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway

(2010) Arash Bahremand et al.   EPILEPSY & BEHAVIOR

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN