Article
Neurosciences
Zijuan Zhang, Hai Li, Yunfang Su, Jinlian Ma, Ye Yuan, Ziyang Yu, Ming Shi, Simai Shao, Zhenqiang Zhang, Christian Holscher
Summary: Research demonstrates that the CCK analogue has neuroprotective effects and improves locomotor function in an acute PD mouse model. It acts by restoring dopaminergic neuron count and synapse number, reducing neuroinflammation and autophagy impairment, and protecting against mitochondrial and ER damage.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Abdolvahed Narmashiri, Mojtaba Abbaszadeh, Ali Ghazizadeh
Summary: This article provides a comprehensive review and meta-analysis on the effects of MPTP on memory and motor functions in Parkinson's disease. The results show that MPTP not only significantly affects motor functions, but also various mnemonic processes. However, no systematic relationship between the MPTP injection protocol parameters and the extent of induced PD symptoms was found.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Eduard Bentea, Laura De Pauw, Lise Verbruggen, Lila C. Winfrey, Lauren Deneyer, Cynthia Moore, Giulia Albertini, Hideyo Sato, Ann Van Eeckhaut, Charles K. Meshul, Ann Massie
Summary: Our study revealed age-related protection against proteasome inhibition-induced nigrostriatal degeneration in xCT(-/-) mice, while xCT deletion failed to protect nigral dopaminergic neurons of aged mice against MPTP-induced toxicity. This provides new insights into the role of system x(c)(-) in mechanisms of dopaminergic cell loss and its interaction with aging.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Khairiah Razali, Mohd Hamzah Mohd Nasir, Noratikah Othman, Abd Almonem Doolaanea, Jaya Kumar, Wisam Nabeel Ibrahim, Wael M. Y. Mohamed
Summary: Parkinson's disease is a common brain motor disorder characterized by motor impairments. Research on the pathogenesis of PD is ongoing, and zebrafish has emerged as a useful model for studying PD. This study demonstrates the effects of MPTP on zebrafish swimming behavior and provides insights into the establishment of PD animal models.
Article
Neurosciences
Hairong Peng, Shui Yu, Yukai Zhang, Yanqing Yin, Jiawei Zhou
Summary: A wealth of evidence suggests that gastrointestinal dysfunction is associated with Parkinson's disease (PD), but the mechanisms are not well-defined. This study reveals the importance of intestinal dopamine D2 receptor (DRD2) activity and succinate from the gut microbiome in the survival of nigral dopaminergic neurons.
NEUROSCIENCE BULLETIN
(2022)
Article
Immunology
Hyongjun Jeon, Chang-Hwan Bae, Yukyoung Lee, Hee-Young Kim, Seungtae Kim
Summary: Korean red ginseng (KRG) has anti-inflammatory effects in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mouse model, and can influence microbiome composition, thereby preventing dopaminergic neuronal death and expression of inflammatory factors.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi Shen
Summary: This study compared the effects of rotenone and MPTP in two commonly used mouse models of chronic PD. The results showed that the MPTP model accurately reproduced the pathological features of PD, while the rotenone model was more suitable for studying mitochondrial dysfunction and Lewy body formation in PD.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Crystallography
Maya Chochkova, Rusi Rusew, Reni Kalfin, Lyubka Tancheva, Maria Lazarova, Hristina Sbirkova-Dimitrova, Andrey Popatanasov, Krasimira Tasheva, Boris Shivachev, Nejc Petek, Martin Sticha
Summary: Parkinson's disease is a common neurodegenerative disorder with severe side effects associated with current treatments. In this study, a new compound, CA(2-Me)-Am, was synthesized and shown to improve memory performance and neuromuscular coordination in an experimental model of Parkinson's disease.
Article
Pharmacology & Pharmacy
Babita Singh, Shivani Pandey, Mohammad Rumman, Shashank Kumar, Prem Prakash Kushwaha, Rajesh Verma, Abbas Ali Mahdi
Summary: The study showed that Bacopa monnieri extract has neuroprotective and neurorescue effects against MPTP-induced degeneration of dopaminergic neurons, potentially slowing down disease progression and delaying neurodegeneration in Parkinson's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Vincent M. Lombardo, Louise Bernier, Ming Z. Chen, William Farrell, Andrew Flick, Philippe Nuhant, Neal W. Sach, Yong Tao, John Trujillo
Summary: Chiral piperidines are commonly found in approved drugs and drug candidates, but their synthesis faces challenges of scalability and stereochemical control. This research focused on accessing stereochemically pure 3,4-disubstituted piperidines through a classical resolution method, which could have broader utility in pharmaceutical intermediates. The practical synthesis described in this work allows for the production of kilogram quantities of enantiopure precursor, enabling scale-up efforts for toxicology studies.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Medicine, Research & Experimental
Alexander Kim, Ekaterina Pavlova, Anna Kolacheva, Vsevolod Bogdanov, Liliya Dilmukhametova, Viktor Blokhin, Lev Valuev, Ivan Valuev, Marina Gorshkova, Michael Ugrumov
Summary: The fight against neurodegenerative diseases, including Parkinson's disease (PD), is a global challenge. This study aims to develop an early diagnosis of PD using an intranasal provocative test on animal models.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Shendong Jing, Zhenhai Wang, Jun Zhang, Xianfeng Li, Ruifei Huang
Summary: Neferine was shown to have a neuroprotective effect against MPTP-induced Parkinson's in mice by reducing pro-inflammatory cytokines levels and increasing dopamine levels. This indicates that neferine could potentially be used as a drug to treat Parkinson's disease with minimal side effects, pending further trials.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Agriculture, Multidisciplinary
Chuanqi Chu, Tiantian Li, Leilei Yu, Yiwen Li, Miaoyu Li, Min Guo, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Chen
Summary: Dietary patterns, specifically a low-protein, high-carbohydrate (LPHC) diet, have potential protective effects on Parkinson's disease (PD) by improving motor deficits, increasing dopamine levels, and normalizing gut bacterial composition. Key mediators in this process include fibroblast growth factor 21 (FGF-21), aromatic amino acids (AAAs), microbial metabolites (TUDCA and taurine), and the gut-microbiota-brain axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Neurosciences
Yun-Mi Kim, Su Yeon Choi, Onyou Hwang, Joo-Yong Lee
Summary: This study investigated the potential neuroprotective effects of exogenous pyruvate in a mouse model of Parkinson's disease. The results showed that sodium pyruvate administration could protect nigral DA neurons from degeneration and alleviate the associated motor deficits, indicating its therapeutic potential for PD and related neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Adeola Oluwatosin Adedara, Guilherme Wildner, Julia Sepel Loreto, Matheus Mulling dos Santos, Amos Olalekan Abolaji, Nilda Vargas Barbosa
Summary: The study investigated the protective effects of kaempferol (KMP) against the toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Drosophila melanogaster. It was found that MPTP exposure caused mortality, developmental disorders, locomotor deficits, disruption of circadian rhythm, oxidative stress, and mitochondrial dysfunction in flies. However, KMP supplementation counteracted these toxic effects, improving survival, locomotion, circadian cycle, and restoring antioxidant enzymes and mitochondrial functionality. Therefore, KMP shows promise in mitigating the toxic effects of MPTP and potentially in the treatment of Parkinson's disease.
Correction
Neurosciences
D. Rial, F. S. Duarte, J. C. Xikota, A. E. Schmitz, A. L. Dafre, C. P. Figueiredo, R. Walz, R. D. S. Prediger
Article
Pharmacology & Pharmacy
Nair C. F. Castro, Izabelle S. Silva, Sabrina C. Cartagenes, Luanna M. P. Fernandes, Paula C. Ribera, Mayara A. Barros, Rui D. Prediger, Eneas A. Fontes-Junior, Cristiane S. F. Maia
Summary: This study evaluated the long-lasting neurobehavioral and nociceptive consequences in adult rats and mice exposed to morphine during pregnancy and lactation periods. The results showed that both male and female rats exhibited anxiety- and depressive-like behaviors, while mice displayed alterations in nociceptive responses. These findings suggest that intrauterine and lactation exposure to morphine can have long-lasting effects on psychological and pain responses in adulthood.
Article
Biochemistry & Molecular Biology
Ingrid Del Castilo, Arthur S. Neumann, Felipe S. Lemos, Marco A. De Bastiani, Felipe L. Oliveira, Eduardo R. Zimmer, Amanda M. Rego, Cristiane C. P. Hardoim, Luis Caetano M. Antunes, Flavio A. Lara, Claudia P. Figueiredo, Julia R. Clarke
Summary: This study investigated the effects of long-term exposure to GBH-RUp on the gut environment in mice and found that it caused morphological and functional changes in the gut, which correlated with behavioral changes similar to those observed in patients with neurodevelopmental disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Danilo Predes, Lorena A. Maia, Isadora Matias, Hannah Paola Mota Araujo, Carolina Soares, Fernanda G. Q. Barros-Aragao, Luiz F. S. Oliveira, Renata R. Reis, Nathalia G. Amado, Alessandro B. C. Simas, Fabio A. Mendes, Flavia C. A. Gomes, Claudia P. Figueiredo, Jose G. Abreu
Summary: This study identifies quercitrin as a novel Wnt signaling potentiator through various experimental models and approaches. Quercitrin enhances the signaling pathway and has positive effects on neuronal function. Moreover, it rescues memory impairment caused by Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Talita Nascimento da Silva, Emanuelle V. de Lima, Thais Nogueira Barradas, Carla G. Testa, Paulo H. S. Picciani, Claudia P. Figueiredo, Flavia A. do Carmo, Julia R. Clarke
Summary: Several human pathogens can cause long-lasting neurological damage, and gene therapy (GT) approaches have been explored as a potential therapeutic intervention. Viral and non-viral vectors are used for gene delivery, with non-viral vectors showing promise due to their safety and versatility. Different types of nanosystems are applied as non-viral vectors, and they can help deliver gene-modifying molecules to prevent neurological damage associated with infectious diseases.
MATERIALS TODAY BIO
(2023)
Article
Dermatology
Rosane Schenkel de Aquino, Aledson Rosa Torres, Alcir Luiz Dafre, Adair Roberto Soares Santos
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Cardiac & Cardiovascular Systems
Guilherme Loureiro Fialho, Richard L. Verrier, Andre D'Avila, Hiago Murilo Melo, Peter Wolf, Roger Walz, Katia Lin
Summary: This study is the first to demonstrate the concurrent electrical dispersion and diastolic dysfunction in people with epilepsy. These noninvasive biomarkers could be useful for early detection of the Epileptic Heart condition.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana Cristina de Bem Alves, Aderbal Silva Aguiar
Summary: Fatigue is a non-motor symptom of Parkinson's disease (PD) linked to compromised dopamine neurotransmission. This study examines the effects of caffeine (A(2A)R non-selective antagonist) and haloperidol (D2R selective antagonist) treatment in a mouse model of PD-induced fatigue. The results suggest that A(2A)R-D2R heterodimer is involved in central fatigue of PD, and A(2A)R-D2R antagonism has potential for the management of PD.
PURINERGIC SIGNALLING
(2023)
Article
Cell Biology
Fabricia L. Fontes-Dantas, Gabriel G. Fernandes, Elisa G. Gutman, Emanuelle V. De Lima, Leticia S. Antonio, Mariana B. Hammerle, Hannah P. Mota-Araujo, Lilian C. Colodeti, Suzana M. B. Araujo, Gabrielle M. Froz, Talita N. da Silva, Larissa A. Duarte, Andreza L. Salvio, Karina L. Pires, Luciane A. A. Leon, Claudia Cristina F. Vasconcelos, Luciana Romao, Luiz Eduardo B. Savio, Jerson L. Silva, Robson da Costa, Julia R. Clarke, Andrea T. Da Poian, Soniza V. Alves-Leon, Giselle F. Passos, Claudia P. Figueiredo
Summary: Cognitive dysfunction in post-COVID-19 syndrome may be caused by the release of SARS-CoV-2 Spike protein, which can lead to neuroinflammation, synapse elimination, and memory dysfunction mediated by Toll-like receptor 4 (TLR4) signaling. Infusing Spike protein into the brains of mice reproduced cognitive impairment similar to post-COVID-19 syndrome. In a group of 86 mild COVID-19 patients, a specific TLR4 genotype was associated with poor cognitive outcome. These findings highlight TLR4 as a key target for investigating long-term cognitive dysfunction after COVID-19 infection.
Article
Pharmacology & Pharmacy
Vinicius Santos Alves, Joyce Pereira da Silva, Fabiana Cristina Rodrigues, Suzana Maria Bernardino Araujo, Andre Luiz Gouvea, Raissa Leite-Aguiar, Stephanie Alexia Cristina Silva Santos, Milla Souza Pessoa da Silva, Fernanda Silva Ferreira, Eduardo Peil Marques, Beatriz Amanda Barbosa Rangel dos Passos, Tatiana Maron-Gutierrez, Eleonora Kurtenbach, Robson da Costa, Claudia Pinto Figueiredo, Angela T. S. Wyse, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio
Summary: Sepsis is a severe and potentially fatal condition caused by multiple factors, which can lead to a high risk of death. Sepsis-associated encephalopathy is a condition where the intense inflammatory response has detrimental effects on the brain. The activation of the P2X7 receptor, which is abundantly expressed in the brain, plays a role in chronic neurodegenerative and neuroinflammatory diseases, but its function in long-term neurological impairment caused by sepsis is still unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Vinicius Santos Alves, Stephanie Alexia Cristina Silva Santos, Raissa Leite-Aguiar, Elaine Paiva-Pereira, Renata Rodrigues dos Reis, Mariana L. Calazans, Gabriel Gripp Fernandes, Leticia Silva Antonio, Emanuelle V. de Lima, Eleonora Kurtenbach, Jerson Lima Silva, Fabricia Lima Fontes-Dantas, Giselle Fazzioni Passos, Claudia Pinto Figueiredo, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio
Summary: Despite the unclear mechanism, the Spike protein of SARS-CoV-2 can affect microglial purinergic signaling and may play a role in the neuropathology of COVID-19. Evidence suggests that the Spike protein can activate pattern recognition receptors and cause neuroinflammation, leading to long-term sequelae of the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Camila A. Zanella, Naiani Marques, Stella Junqueira, Rui D. Prediger, Carla I. Tasca, Helena I. Cimarosti
Summary: The nucleoside guanosine can modulate the SUMOylation process in neurons and astrocytes in vivo, improving short-term memory in young mice but not in aged mice. Guanosine has no effect on depressive-like behaviors but does play a role in behavioral coping strategies. This study highlights the involvement of SUMOylation in guanosine's modulatory and neuroprotective effects.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Luis F. B. Marqueze, Amanda K. Costa, Giulia S. Pedroso, Franciane F. Vasconcellos, Bruna I. Pilger, Schellen Kindermann, Vanessa M. Andrade, Tatyana Nery, Ana C. B. Alves, Aderbal A. Silva, Stephanie R. S. Carvalhal, Matheus F. Zazula, Katya Naliwaiko, Luiz C. Fernandes, Zsolt Radak, Ricardo A. Pinho
Summary: This study investigated the effects of physical training on behavior, redox balance, and genomic stability in models of aggressive brain cancer. The results showed that moderate aerobic exercise could have a beneficial impact on GBM treatment by improving behavior and reducing genomic instability.
Review
Pharmacology & Pharmacy
Gustavo Oliveira dos Reis, Ziliani da Silva Buss, Taina Larissa Lubschinski, Eduarda Talita Bramorski Mohr, Mariano Felisberto, Thais Elisete Pilatti Ribeiro, Julia Salvan da Rosa, Filipe Carvalho Matheus, Eduardo Monguilhott Dalmarco
Summary: In this article, the authors reviewed the literature on the anti-inflammatory effects of coumarins in LPS-induced ALI in mice. They concluded that coumarins have significant anti-inflammatory effects in reducing edema and leukocyte influx in the lungs, which is comparable to the reference anti-inflammatory drug dexamethasone.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Aderbal Silva Aguiar Jr
Summary: The World Anti-Doping Agency (WADA) classifies cannabis, all phytocannabinoids, and synthetics as doping, except for CBD. Cannabis does not enhance performance nor worsen it, and the health risks for athletes have been overestimated after 20 years of research. The problem lies in the complex definition of the spirit of sports, which goes beyond performance and injury prevention, becoming a moral policing issue. This evidence-based perspective argues for the removal of cannabis and phytocannabinoids from the WADA Prohibited List.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)